Cellular Senescence

"Cellular Senescence" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing CELL DEATH. Senescence can be induced by DNA DAMAGE or other cellular stresses, such as OXIDATIVE STRESS.

Descriptor ID	D016922
MeSH Number(s)	G04.043
Concept/Terms	Cellular Senescence Cellular Senescence Senescence, Cellular Cell Senescence Senescence, Cell Cell Aging Cell Aging Cellular Ageing Ageing, Cellular Aging, Cell Senescence, Replicative Cellular Aging Aging, Cellular Replicative Senescence Cell Ageing Ageing, Cell Senescence-Associated Secretory Phenotype Senescence-Associated Secretory Phenotype Phenotype, Senescence-Associated Secretory Secretory Phenotype, Senescence-Associated Senescence Associated Secretory Phenotype

Below are MeSH descriptors whose meaning is more general than "Cellular Senescence".

Biological Sciences [G]
Cell Physiological Phenomena [G04]
Cellular Senescence [G04.043]

Below are MeSH descriptors whose meaning is related to "Cellular Senescence".

Below are MeSH descriptors whose meaning is more specific than "Cellular Senescence".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cellular Senescence" by people in this website by year, and whether "Cellular Senescence" was a major or minor topic of these publications.

Bar chart showing 78 publications over 27 distinct years, with a maximum of 6 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	0	1	1
1994	1	0	1
1995	1	1	2
1996	0	2	2
1999	2	0	2
2000	1	1	2
2001	0	3	3
2002	2	0	2
2003	3	2	5
2004	3	2	5
2005	1	1	2
2006	1	1	2
2007	1	0	1
2008	0	4	4
2009	2	0	2
2010	3	0	3
2011	2	3	5
2012	2	2	4
2013	4	2	6
2014	1	3	4
2016	2	0	2
2017	3	0	3
2018	1	4	5
2019	4	0	4
2020	1	2	3
2021	1	1	2
2022	0	1	1

Below are the most recent publications written about "Cellular Senescence" by people in Profiles.

Cook M, Lin H, Mishra SK, Wang GY. BAY 11-7082 inhibits the secretion of interleukin-6 by senescent human microglia. Biochem Biophys Res Commun. 2022 08 20; 617(Pt 1):30-35.

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Patel D, Potter M, Anaya JM, McGee-Lawrence ME, Hamrick MW, Hill WD, Isales CM, Fulzele S. Kynurenine induces an age-related phenotype in bone marrow stromal cells. Mech Ageing Dev. 2021 04; 195:111464.

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Trayssac M, Clarke CJ, Stith JL, Snider JM, Newen N, Gault CR, Hannun YA, Obeid LM. Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides. Cell Death Dis. 2021 01 04; 12(1):27.

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Potter ML, Hill WD, Isales CM, Hamrick MW, Fulzele S. MicroRNAs are critical regulators of senescence and aging in mesenchymal stem cells. Bone. 2021 01; 142:115679.

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Luo X, Zhou J, Wang Z, He Y, Yu L, Ma S, Wang S, Wang X, Yuan Y, Li D, Cui T, Ding Y. An inhibitor role of Nrf2 in the regulation of myocardial senescence and dysfunction after myocardial infarction. Life Sci. 2020 Oct 15; 259:118199.

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Dharmalingam P, Talakatta G, Mitra J, Wang H, Derry PJ, Nilewski LG, McHugh EA, Fabian RH, Mendoza K, Vasquez V, Hegde PM, Kakadiaris E, Roy T, Boldogh I, Hegde VL, Mitra S, Tour JM, Kent TA, Hegde ML. Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle. ACS Nano. 2020 03 24; 14(3):2827-2846.

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Kondrikov D, Elmansi A, Bragg RT, Mobley T, Barrett T, Eisa N, Kondrikova G, Schoeinlein P, Aguilar-Perez A, Shi XM, Fulzele S, Lawrence MM, Hamrick M, Isales C, Hill W. Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal stem cells through the aryl hydrocarbon receptor pathway. Exp Gerontol. 2020 02; 130:110805.

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Kumar R, Bishop E, Bridges WC, Tharayil N, Sekhon RS. Sugar partitioning and source-sink interaction are key determinants of leaf senescence in maize. Plant Cell Environ. 2019 09; 42(9):2597-2611.

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Zhong G, Qin S, Townsend D, Schulte BA, Tew KD, Wang GY. Oxidative stress induces senescence in breast cancer stem cells. Biochem Biophys Res Commun. 2019 07 05; 514(4):1204-1209.

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Ridout KK, Ridout SJ, Guille C, Mata DA, Akil H, Sen S. Physician-Training Stress and Accelerated Cellular Aging. Biol Psychiatry. 2019 11 01; 86(9):725-730.

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