Yiannis Koutalos

Title
InstitutionMedical University of South Carolina
DepartmentOphthalmology
AddressP.O. Box MSC 676
712
167 Ashley Ave.
Phone843-792-9180
Fax843-792-1723
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Fan J, Liu J, Liu J, Chen C, Koutalos Y, Crosson CE. Evidence for ceramide induced cytotoxicity in retinal ganglion cells. Exp Eye Res. 2021 10; 211:108762. PMID: 34499916.
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    2. Boyer NP, Thompson DA, Koutalos Y. Relative Contributions of All-Trans and 11-Cis Retinal to Formation of Lipofuscin and A2E Accumulating in Mouse Retinal Pigment Epithelium. Invest Ophthalmol Vis Sci. 2021 02 01; 62(2):1. PMID: 33523199.
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    3. Chen C, Kono M, Koutalos Y. Photooxidation mediated by 11-cis and all-trans retinal in single isolated mouse rod photoreceptors. Photochem Photobiol Sci. 2020 Oct 14; 19(10):1300-1307. PMID: 32812970.
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    4. Dey N, Hong S, Ach T, Koutalos Y, Curcio CA, Smith RT, Gerig G. Tensor decomposition of hyperspectral images to study autofluorescence in age-related macular degeneration. Med Image Anal. 2019 08; 56:96-109. PMID: 31203169.
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    5. Jophlin LL, Koutalos Y, Chen C, Shah V, Rockey DC. Hepatic stellate cells retain retinoid-laden lipid droplets after cellular transdifferentiation into activated myofibroblasts. Am J Physiol Gastrointest Liver Physiol. 2018 11 01; 315(5):G713-G721. PMID: 30024770.
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    6. Anderson DMG, Ablonczy Z, Koutalos Y, Hanneken AM, Spraggins JM, Calcutt MW, Crouch RK, Caprioli RM, Schey KL. Bis(monoacylglycero)phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas. Sci Rep. 2017 12 11; 7(1):17352. PMID: 29229934.
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    7. Chen C, Adler L, Goletz P, Gonzalez-Fernandez F, Thompson DA, Koutalos Y. Interphotoreceptor retinoid-binding protein removes all-trans-retinol and retinal from rod outer segments, preventing lipofuscin precursor formation. J Biol Chem. 2017 11 24; 292(47):19356-19365. PMID: 28972139.
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    8. Adler L, Chen C, Koutalos Y. All-trans retinal levels and formation of lipofuscin precursors after bleaching in rod photoreceptors from wild type and Abca4-/- mice. Exp Eye Res. 2017 02; 155:121-127. PMID: 28219732.
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    9. Frederiksen R, Nymark S, Kolesnikov AV, Berry JD, Adler L, Koutalos Y, Kefalov VJ, Cornwall MC. Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods. J Gen Physiol. 2016 07; 148(1):1-11. PMID: 27353443.
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    10. Adler L, Boyer NP, Anderson DM, Spraggins JM, Schey KL, Hanneken A, Ablonczy Z, Crouch RK, Koutalos Y. Determination of N-retinylidene-N-retinylethanolamine (A2E) levels in central and peripheral areas of human retinal pigment epithelium. Photochem Photobiol Sci. 2015 Nov; 14(11):1983-90. PMID: 26323192.
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    11. Pallitto P, Ablonczy Z, Jones EE, Drake RR, Koutalos Y, Crouch RK, Donello J, Herrmann J. A2E and lipofuscin distributions in macaque retinal pigment epithelium are similar to human. Photochem Photobiol Sci. 2015 Oct; 14(10):1888-95. PMID: 26223373.
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    12. Crouch RK, Koutalos Y, Kono M, Schey K, Ablonczy Z. A2E and Lipofuscin. Prog Mol Biol Transl Sci. 2015; 134:449-63. PMID: 26310170.
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    13. Wu BX, Fan J, Boyer NP, Jenkins RW, Koutalos Y, Hannun YA, Crosson CE. Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration. PLoS One. 2015; 10(7):e0133032. PMID: 26168297.
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    14. Adler L, Boyer NP, Chen C, Ablonczy Z, Crouch RK, Koutalos Y. The 11-cis Retinal Origins of Lipofuscin in the Retina. Prog Mol Biol Transl Sci. 2015; 134:e1-12. PMID: 26310175.
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    15. Adler L, Boyer NP, Chen C, Koutalos Y. Kinetics of rhodopsin's chromophore monitored in a single photoreceptor. Methods Mol Biol. 2015; 1271:327-43. PMID: 25697533.
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    16. Blue A, Mitcham M, Koutalos Y, Howell D, Leaphart A. Attaining interprofessional competencies through a student interprofessional fellowship program. J Interprof Care. 2015 May; 29(3):253-5. PMID: 25180629.
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    17. Anderson DM, Ablonczy Z, Koutalos Y, Spraggins J, Crouch RK, Caprioli RM, Schey KL. High resolution MALDI imaging mass spectrometry of retinal tissue lipids. J Am Soc Mass Spectrom. 2014 Aug; 25(8):1394-403. PMID: 24819461.
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    18. Ablonczy Z, Smith N, Anderson DM, Grey AC, Spraggins J, Koutalos Y, Schey KL, Crouch RK. The utilization of fluorescence to identify the components of lipofuscin by imaging mass spectrometry. Proteomics. 2014 Apr; 14(7-8):936-44. PMID: 24453194.
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    19. Adler L, Chen C, Koutalos Y. Mitochondria contribute to NADPH generation in mouse rod photoreceptors. J Biol Chem. 2014 Jan 17; 289(3):1519-28. PMID: 24297174.
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    20. Ablonczy Z, Higbee D, Grey AC, Koutalos Y, Schey KL, Crouch RK. Similar molecules spatially correlate with lipofuscin and N-retinylidene-N-retinylethanolamine in the mouse but not in the human retinal pigment epithelium. Arch Biochem Biophys. 2013 Nov 15; 539(2):196-202. PMID: 23969078.
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    21. Ablonczy Z, Higbee D, Anderson DM, Dahrouj M, Grey AC, Gutierrez D, Koutalos Y, Schey KL, Hanneken A, Crouch RK. Lack of correlation between the spatial distribution of A2E and lipofuscin fluorescence in the human retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2013 Aug 15; 54(8):5535-42. PMID: 23847313.
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    22. Koutalos Y. Will the rod bend or break? Analyzing the structural resilience of cellular organelles. Biophys J. 2013 Jan 22; 104(2):284-5. PMID: 23442849.
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    23. Tang PH, Kono M, Koutalos Y, Ablonczy Z, Crouch RK. New insights into retinoid metabolism and cycling within the retina. Prog Retin Eye Res. 2013 Jan; 32:48-63. PMID: 23063666.
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    24. Frederiksen R, Boyer NP, Nickle B, Chakrabarti KS, Koutalos Y, Crouch RK, Oprian D, Cornwall MC. Low aqueous solubility of 11-cis-retinal limits the rate of pigment formation and dark adaptation in salamander rods. J Gen Physiol. 2012 Jun; 139(6):493-505. PMID: 22641642.
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    25. Chen C, Thompson DA, Koutalos Y. Reduction of all-trans-retinal in vertebrate rod photoreceptors requires the combined action of RDH8 and RDH12. J Biol Chem. 2012 Jul 13; 287(29):24662-70. PMID: 22621924.
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    26. Boyer NP, Higbee D, Currin MB, Blakeley LR, Chen C, Ablonczy Z, Crouch RK, Koutalos Y. Lipofuscin and N-retinylidene-N-retinylethanolamine (A2E) accumulate in retinal pigment epithelium in absence of light exposure: their origin is 11-cis-retinal. J Biol Chem. 2012 Jun 22; 287(26):22276-86. PMID: 22570475.
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    27. Masutomi K, Chen C, Nakatani K, Koutalos Y. All-trans retinal mediates light-induced oxidation in single living rod photoreceptors. Photochem Photobiol. 2012 Nov-Dec; 88(6):1356-61. PMID: 22417174.
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    28. Boyer NP, Tang PH, Higbee D, Ablonczy Z, Crouch RK, Koutalos Y. Lipofuscin and A2E accumulate with age in the retinal pigment epithelium of Nrl-/- mice. Photochem Photobiol. 2012 Nov-Dec; 88(6):1373-7. PMID: 22417141.
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    29. Boyer NP, Chen C, Koutalos Y. Preparation of living isolated vertebrate photoreceptor cells for fluorescence imaging. J Vis Exp. 2011 Jun 22; (52). PMID: 21730941.
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    30. Grey AC, Crouch RK, Koutalos Y, Schey KL, Ablonczy Z. Spatial localization of A2E in the retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2011 Jun 06; 52(7):3926-33. PMID: 21357388.
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    31. Blakeley LR, Chen C, Chen CK, Chen J, Crouch RK, Travis GH, Koutalos Y. Rod outer segment retinol formation is independent of Abca4, arrestin, rhodopsin kinase, and rhodopsin palmitylation. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3483-91. PMID: 21398289.
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    32. Blue AV, Charles L, Howell D, Koutalos Y, Mitcham M, Nappi J, Zoller J. Introducing students to patient safety through an online interprofessional course. Adv Med Educ Pract. 2010; 1:107-14. PMID: 23745069.
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    33. Gutierrez DB, Blakeley L, Goletz PW, Schey KL, Hanneken A, Koutalos Y, Crouch RK, Ablonczy Z. Mass spectrometry provides accurate and sensitive quantitation of A2E. Photochem Photobiol Sci. 2010 Nov; 9(11):1513-9. PMID: 20931136.
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    34. Chen C, Koutalos Y. Rapid formation of all-trans retinol after bleaching in frog and mouse rod photoreceptor outer segments. Photochem Photobiol Sci. 2010 Nov; 9(11):1475-9. PMID: 20697621.
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    35. Johnson D, Chen C, Koutalos Y. 2-Hydroxypropyl-beta-cyclodextrin removes all-trans retinol from frog rod photoreceptors in a concentration-dependent manner. J Ocul Pharmacol Ther. 2010 Jun; 26(3):245-8. PMID: 20565310.
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    36. Koutalos Y, Cornwall MC. Microfluorometric measurement of the formation of all-trans-retinol in the outer segments of single isolated vertebrate photoreceptors. Methods Mol Biol. 2010; 652:129-47. PMID: 20552426.
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    37. Koutalos Y. Measurement of the mobility of all-trans-retinol with two-photon fluorescence recovery after photobleaching. Methods Mol Biol. 2010; 652:115-27. PMID: 20552425.
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    38. Chen C, Blakeley LR, Koutalos Y. Formation of all-trans retinol after visual pigment bleaching in mouse photoreceptors. Invest Ophthalmol Vis Sci. 2009 Aug; 50(8):3589-95. PMID: 19264891.
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    39. Imanishi Y, Lodowski KH, Koutalos Y. Two-photon microscopy: shedding light on the chemistry of vision. Biochemistry. 2007 Aug 28; 46(34):9674-84. PMID: 17676772.
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    40. Wu Q, Blakeley LR, Cornwall MC, Crouch RK, Wiggert BN, Koutalos Y. Interphotoreceptor retinoid-binding protein is the physiologically relevant carrier that removes retinol from rod photoreceptor outer segments. Biochemistry. 2007 Jul 24; 46(29):8669-79. PMID: 17602665.
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    41. Wu Q, Chen C, Koutalos Y. Longitudinal diffusion of a polar tracer in the outer segments of rod photoreceptors from different species. Photochem Photobiol. 2006 Nov-Dec; 82(6):1447-51. PMID: 16906792.
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    42. Ala-Laurila P, Kolesnikov AV, Crouch RK, Tsina E, Shukolyukov SA, Govardovskii VI, Koutalos Y, Wiggert B, Estevez ME, Cornwall MC. Visual cycle: Dependence of retinol production and removal on photoproduct decay and cell morphology. J Gen Physiol. 2006 Aug; 128(2):153-69. PMID: 16847097.
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    43. Pappa A, Brown D, Koutalos Y, DeGregori J, White C, Vasiliou V. Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells. J Biol Chem. 2005 Jul 29; 280(30):27998-8006. PMID: 15905174.
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    44. Chen C, Tsina E, Cornwall MC, Crouch RK, Vijayaraghavan S, Koutalos Y. Reduction of all-trans retinal to all-trans retinol in the outer segments of frog and mouse rod photoreceptors. Biophys J. 2005 Mar; 88(3):2278-87. PMID: 15626704.
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    45. Tsina E, Chen C, Koutalos Y, Ala-Laurila P, Tsacopoulos M, Wiggert B, Crouch RK, Cornwall MC. Physiological and microfluorometric studies of reduction and clearance of retinal in bleached rod photoreceptors. J Gen Physiol. 2004 Oct; 124(4):429-43. PMID: 15452202.
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    46. Chen C, Nakatani K, Koutalos Y. Free magnesium concentration in salamander photoreceptor outer segments. J Physiol. 2003 Nov 15; 553(Pt 1):125-35. PMID: 14500766.
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    47. Pappa A, Chen C, Koutalos Y, Townsend AJ, Vasiliou V. Aldh3a1 protects human corneal epithelial cells from ultraviolet- and 4-hydroxy-2-nonenal-induced oxidative damage. Free Radic Biol Med. 2003 May 01; 34(9):1178-89. PMID: 12706498.
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    48. Chen C, Jiang Y, Koutalos Y. Dynamic behavior of rod photoreceptor disks. Biophys J. 2002 Sep; 83(3):1403-12. PMID: 12202366.
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    49. Winski SL, Koutalos Y, Bentley DL, Ross D. Subcellular localization of NAD(P)H:quinone oxidoreductase 1 in human cancer cells. Cancer Res. 2002 Mar 01; 62(5):1420-4. PMID: 11888914.
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    50. Nakatani K, Chen C, Koutalos Y. Calcium diffusion coefficient in rod photoreceptor outer segments. Biophys J. 2002 Feb; 82(2):728-39. PMID: 11806915.
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    51. Nakatani K, Chen C, Yau KW, Koutalos Y. Calcium and phototransduction. Adv Exp Med Biol. 2002; 514:1-20. PMID: 12596912.
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    52. Ebrey T, Koutalos Y. Vertebrate photoreceptors. Prog Retin Eye Res. 2001 Jan; 20(1):49-94. PMID: 11070368.
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    53. Fain GL, Matthews HR, Cornwall MC, Koutalos Y. Adaptation in vertebrate photoreceptors. Physiol Rev. 2001 Jan; 81(1):117-151. PMID: 11152756.
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    54. Koutalos Y, Yau KW. Characterization of guanylyl cyclase and phosphodiesterase activities in single rod outer segments. Methods Enzymol. 2000; 315:742-52. PMID: 10736738.
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    55. Koutalos Y. Intracellular spreading of second messengers. J Physiol. 1999 Sep 15; 519 Pt 3:629. PMID: 10457078.
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    56. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 17012326.
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    57. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 28500718.
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    58. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 15180285.
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    59. Chen C, Nakamura T, Koutalos Y. Cyclic AMP diffusion coefficient in frog olfactory cilia. Biophys J. 1999 May; 76(5):2861-7. PMID: 10233102.
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    60. Huang L, Deng H, Koutalos Y, Ebrey T, Groesbeek M, Lugtenburg J, Tsuda M, Callender RH. A resonance Raman study of the C=C stretch modes in bovine and octopus visual pigments with isotopically labeled retinal chromophores. Photochem Photobiol. 1997 Dec; 66(6):747-54. PMID: 9421961.
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    61. Huang L, Deng H, Weng G, Koutalos Y, Ebrey T, Groesbeek M, Lugtenburg J, Tsuda M, Callender RH. A resonance Raman study of the C=N configurations of octopus rhodopsin, bathorhodopsin, and isorhodopsin. Biochemistry. 1996 Jul 02; 35(26):8504-10. PMID: 8679611.
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    62. Koutalos Y, Yau KW. Regulation of sensitivity in vertebrate rod photoreceptors by calcium. Trends Neurosci. 1996 Feb; 19(2):73-81. PMID: 8820871.
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    63. Koutalos Y, Nakatani K, Tamura T, Yau KW. Characterization of guanylate cyclase activity in single retinal rod outer segments. J Gen Physiol. 1995 Nov; 106(5):863-90. PMID: 8648296.
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    64. Koutalos Y, Nakatani K, Yau KW. The cGMP-phosphodiesterase and its contribution to sensitivity regulation in retinal rods. J Gen Physiol. 1995 Nov; 106(5):891-921. PMID: 8648297.
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    65. Koutalos Y, Brown RL, Karpen JW, Yau KW. Diffusion coefficient of the cyclic GMP analog 8-(fluoresceinyl)thioguanosine 3',5' cyclic monophosphate in the salamander rod outer segment. Biophys J. 1995 Nov; 69(5):2163-7. PMID: 8580360.
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    66. Nakatani K, Koutalos Y, Yau KW. Ca2+ modulation of the cGMP-gated channel of bullfrog retinal rod photoreceptors. J Physiol. 1995 Apr 01; 484 ( Pt 1):69-76. PMID: 7541463.
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    67. Koutalos Y, Nakatani K, Yau KW. Cyclic GMP diffusion coefficient in rod photoreceptor outer segments. Biophys J. 1995 Jan; 68(1):373-82. PMID: 7536055.
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    68. Koutalos Y, Yau KW. A rich complexity emerges in phototransduction. Curr Opin Neurobiol. 1993 Aug; 3(4):513-9. PMID: 8219718.
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    69. Koutalos Y. High-pH form of bovine rhodopsin. Biophys J. 1992 Jan; 61(1):272-5. PMID: 1540695.
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    70. Deng H, Manor D, Weng G, Rath P, Koutalos Y, Ebrey T, Gebhard R, Lugtenburg J, Tsuda M, Callender RH. A resonance Raman study of octopus bathorhodopsin with deuterium labeled retinal chromophores. Photochem Photobiol. 1991 Dec; 54(6):1001-7. PMID: 1775525.
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    71. Deng H, Manor D, Weng G, Rath P, Koutalos Y, Ebrey T, Gebhard R, Lugtenburg J, Tsuda M, Callender RH. Resonance Raman studies of the HOOP modes in octopus bathorhodopsin with deuterium-labeled retinal chromophores. Biochemistry. 1991 May 07; 30(18):4495-502. PMID: 2021639.
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    72. Jonas R, Koutalos Y, Ebrey TG. Purple membrane: surface charge density and the multiple effect of pH and cations. Photochem Photobiol. 1990 Dec; 52(6):1163-77. PMID: 2087503.
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    73. Koutalos Y, Ebrey TG, Gilson HR, Honig B. Octopus photoreceptor membranes. Surface charge density and pK of the Schiff base of the pigments. Biophys J. 1990 Aug; 58(2):493-501. PMID: 2207250.
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    74. Apte DV, Koutalos Y, McFarlane DK, Dawson MJ, Ebrey TG. Phosphorus-31 nuclear magnetic resonance spectroscopy of toad retina. Biophys J. 1989 Sep; 56(3):447-52. PMID: 2506940.
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    75. Koutalos Y, Ebrey TG, Tsuda M, Odashima K, Lien T, Park MH, Shimizu N, Derguini F, Nakanishi K, Gilson HR, et al. Regeneration of bovine and octopus opsins in situ with natural and artificial retinals. Biochemistry. 1989 Mar 21; 28(6):2732-9. PMID: 2525050.
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    76. Koutalos Y, Ebrey TG. Recent progress in vertebrate photoreception. Photochem Photobiol. 1986 Dec; 44(6):809-17. PMID: 3550832.
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