Guanine Nucleotide Exchange Factors
"Guanine Nucleotide Exchange Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Protein factors that promote the exchange of GTP for GDP bound to GTP-BINDING PROTEINS.
| Descriptor ID |
D020662
|
| MeSH Number(s) |
D12.644.360.325.300 D12.776.476.325.300
|
| Concept/Terms |
Guanine Nucleotide Exchange Factors- Guanine Nucleotide Exchange Factors
- Guanine-Nucleotide-Releasing Factor
- Guanine Nucleotide Releasing Factor
- GDP Dissociation Factor
- GDP-GTP Exchange Protein
- GDP GTP Exchange Protein
- GDP Dissociation Stimulators
- GDP-GTP Reversing Factors
- Factors, GDP-GTP Reversing
- GDP GTP Reversing Factors
- Reversing Factors, GDP-GTP
- Guanine Nucleotide Releasing Factors
- GDP Exchange Factors
- Exchange Factors, GDP
- Factors, GDP Exchange
- Guanine Nucleotide Exchange Factor
|
Below are MeSH descriptors whose meaning is more general than "Guanine Nucleotide Exchange Factors".
Below are MeSH descriptors whose meaning is more specific than "Guanine Nucleotide Exchange Factors".
This graph shows the total number of publications written about "Guanine Nucleotide Exchange Factors" by people in this website by year, and whether "Guanine Nucleotide Exchange Factors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 2 | 0 | 2 |
| 2006 | 1 | 1 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 2 | 3 |
| 2012 | 2 | 0 | 2 |
| 2013 | 3 | 0 | 3 |
| 2017 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Guanine Nucleotide Exchange Factors" by people in Profiles.
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Cyclic-AMP induces Nogo-A receptor NgR1 internalization and inhibits Nogo-A-mediated collapse of growth cone. Biochem Biophys Res Commun. 2020 03 12; 523(3):678-684.
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Structural basis for GPCR-independent activation of heterotrimeric Gi proteins. Proc Natl Acad Sci U S A. 2019 08 13; 116(33):16394-16403.
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Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain. Cell Signal. 2018 Jan; 42:281-291.
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The Rho guanine nucleotide exchange factor Syx regulates the balance of dia and ROCK activities to promote polarized-cancer-cell migration. Mol Cell Biol. 2013 Dec; 33(24):4909-18.
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TEM4 is a junctional Rho GEF required for cell-cell adhesion, monolayer integrity and barrier function. J Cell Sci. 2013 Aug 01; 126(Pt 15):3271-7.
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Phosphorylation-mediated 14-3-3 protein binding regulates the function of the rho-specific guanine nucleotide exchange factor (RhoGEF) Syx. J Biol Chem. 2013 Mar 01; 288(9):6640-50.
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VEGF and Angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx. J Cell Biol. 2012 Dec 24; 199(7):1103-15.
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Regulation of the G-protein regulatory-Gai signaling complex by nonreceptor guanine nucleotide exchange factors. J Biol Chem. 2013 Feb 01; 288(5):3003-15.
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Multi-institutional phase 2 clinical and pharmacogenomic trial of tipifarnib plus etoposide for elderly adults with newly diagnosed acute myelogenous leukemia. Blood. 2012 Jan 05; 119(1):55-63.
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G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14?Gai1 complex in live cells. J Biol Chem. 2011 Nov 04; 286(44):38659-38669.