"Apolipoprotein E2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of three major isoforms of apolipoprotein E. In humans, Apo E2 differs from APOLIPOPROTEIN E3 at one residue 158 where arginine is replaced by cysteine (R158--C). In contrast to Apo E3, Apo E2 displays extremely low binding affinity for LDL receptors (RECEPTORS, LDL) which mediate the internalization and catabolism of lipoprotein particles in liver cells. ApoE2 allelic homozygosity is associated with HYPERLIPOPROTEINEMIA TYPE III.
| Descriptor ID |
D053329
|
| MeSH Number(s) |
D10.532.091.500.249 D12.776.070.400.500.249 D12.776.521.120.500.249
|
| Concept/Terms |
Apolipoprotein E2- Apolipoprotein E2
- APOE-epsilon2
- APOE epsilon2
- ApoE2
- APOE-epsilon 2
- APOE epsilon 2
- Apo E-2
- Apo E 2
- Apo E2
- Apolipoprotein E-epsilon2
- Apolipoprotein E epsilon2
- Apolipoprotein E-2
- Apolipoprotein E 2
|
Below are MeSH descriptors whose meaning is more general than "Apolipoprotein E2".
Below are MeSH descriptors whose meaning is more specific than "Apolipoprotein E2".
This graph shows the total number of publications written about "Apolipoprotein E2" by people in this website by year, and whether "Apolipoprotein E2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 3 | 3 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Apolipoprotein E2" by people in Profiles.
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Lower functional connectivity of default mode network in cognitively normal young adults with mutation of APP, presenilins and APOE e4. Brain Imaging Behav. 2017 Jun; 11(3):818-828.
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Validation of association of the apolipoprotein E e2 allele with neurodevelopmental dysfunction after cardiac surgery in neonates and infants. J Thorac Cardiovasc Surg. 2014 Dec; 148(6):2560-6.
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Impaired secretion of apolipoprotein E2 from macrophages. J Biol Chem. 2007 May 04; 282(18):13746-53.
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APOE2 allele increased in tardive dyskinesia. Mov Disord. 2006 Apr; 21(4):540-2.
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Isoforms of apolipoprotein E can modulate tPA-induced clot lysis in vitro. Front Biosci. 2002 Aug 01; 7:a163-8.
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Apolipoprotein E and Alzheimer's disease: the protective effects of ApoE2 and E3. J Alzheimers Dis. 2002 Jun; 4(3):145-54.
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Genetic and environmental risk factors for intracerebral hemorrhage: preliminary results of a population-based study. Stroke. 2002 May; 33(5):1190-5.