"Apolipoprotein E3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 34-kDa glycosylated protein. A major and most common isoform of apolipoprotein E. Therefore, it is also known as apolipoprotein E (ApoE). In human, Apo E3 is a 299-amino acid protein with a cysteine at the 112 and an arginine at the 158 position. It is involved with the transport of TRIGLYCERIDES; PHOSPHOLIPIDS; CHOLESTEROL; and CHOLESTERYL ESTERS in and out of the cells.
| Descriptor ID |
D053318
|
| MeSH Number(s) |
D10.532.091.500.500 D12.776.070.400.500.500 D12.776.521.120.500.500
|
| Concept/Terms |
Apolipoprotein E3- Apolipoprotein E3
- Apo E3
- APOE-epsilon 3
- APOE epsilon 3
- Isoapolipoprotein E3
- ApoE3
- Apolipoprotein E-3
- Apolipoprotein E 3
- Apolipoprotein E-epsilon3
- Apolipoprotein E epsilon3
- Apo E-3
- Apo E 3
- APOE-epsilon3
- APOE epsilon3
|
Below are MeSH descriptors whose meaning is more general than "Apolipoprotein E3".
Below are MeSH descriptors whose meaning is more specific than "Apolipoprotein E3".
This graph shows the total number of publications written about "Apolipoprotein E3" by people in this website by year, and whether "Apolipoprotein E3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2007 | 1 | 1 | 2 |
| 2012 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Apolipoprotein E3" by people in Profiles.
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Cyclic O3 exposure synergizes with aging leading to memory impairment in male APOE e3, but not APOE e4, targeted replacement mice. Neurobiol Aging. 2019 Sep; 81:9-21.
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Proteomic analysis of mice expressing human ApoE demonstrates no differences in global protein solubility between APOE 3 and APOE 4 young mice. Electrophoresis. 2012 Dec; 33(24):3745-55.
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A monomeric, biologically active, full-length human apolipoprotein E. Biochemistry. 2007 Sep 18; 46(37):10722-32.
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Impaired secretion of apolipoprotein E2 from macrophages. J Biol Chem. 2007 May 04; 282(18):13746-53.
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Isoforms of apolipoprotein E can modulate tPA-induced clot lysis in vitro. Front Biosci. 2002 Aug 01; 7:a163-8.
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Apolipoprotein E and Alzheimer's disease: the protective effects of ApoE2 and E3. J Alzheimers Dis. 2002 Jun; 4(3):145-54.
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Reduction in amyloid A amyloid formation in apolipoprotein-E-deficient mice. Am J Pathol. 1998 May; 152(5):1387-95.