"Apolipoproteins E" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
| Descriptor ID |
D001057
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| MeSH Number(s) |
D10.532.091.500 D12.776.070.400.500 D12.776.521.120.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Apolipoproteins E".
Below are MeSH descriptors whose meaning is more specific than "Apolipoproteins E".
This graph shows the total number of publications written about "Apolipoproteins E" by people in this website by year, and whether "Apolipoproteins E" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 1 | 2 |
| 1996 | 1 | 0 | 1 |
| 1997 | 2 | 1 | 3 |
| 1998 | 3 | 0 | 3 |
| 1999 | 2 | 1 | 3 |
| 2000 | 2 | 0 | 2 |
| 2001 | 1 | 0 | 1 |
| 2002 | 4 | 2 | 6 |
| 2003 | 1 | 1 | 2 |
| 2004 | 1 | 2 | 3 |
| 2005 | 1 | 0 | 1 |
| 2006 | 2 | 0 | 2 |
| 2008 | 1 | 1 | 2 |
| 2009 | 2 | 2 | 4 |
| 2010 | 3 | 4 | 7 |
| 2011 | 4 | 1 | 5 |
| 2012 | 3 | 3 | 6 |
| 2013 | 1 | 3 | 4 |
| 2014 | 2 | 0 | 2 |
| 2015 | 5 | 3 | 8 |
| 2016 | 1 | 1 | 2 |
| 2017 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Apolipoproteins E" by people in Profiles.
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PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer's disease risk. Sci Rep. 2022 08 02; 12(1):13264.
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An Ig ? Marker Genotype Is a Strong Risk Factor for Alzheimer Disease, Independent of Apolipoprotein E e4 Genotype. J Immunol. 2020 09 01; 205(5):1318-1322.
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New approaches to genetic predisposition for hemorrhagic stroke in sickle cell disease. J Clin Hypertens (Greenwich). 2018 06; 20(6):1078-1079.
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Association between Cholesterol Exposure and Neuropathological Findings: The ACT Study. J Alzheimers Dis. 2017; 59(4):1307-1315.
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Gender, apolipoprotein E genotype, and mesial temporal atrophy: 2-year follow-up in patients with stable mild cognitive impairment and with progression from mild cognitive impairment to Alzheimer's disease. Neuroradiology. 2016 Nov; 58(11):1143-1151.
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The role of endoplasmic reticulum stress in hippocampal insulin resistance. Exp Neurol. 2016 Mar; 277:261-267.
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APOE Polymorphism Affects Brain Default Mode Network in Healthy Young Adults: A STROBE Article. Medicine (Baltimore). 2015 Dec; 94(52):e1734.
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PEP-1-MsrA ameliorates inflammation and reduces atherosclerosis in apolipoprotein E deficient mice. J Transl Med. 2015 Sep 26; 13:316.
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Hepatic overexpression of methionine sulfoxide reductase A reduces atherosclerosis in apolipoprotein E-deficient mice. J Lipid Res. 2015 Oct; 56(10):1891-900.
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Citalopram for the Treatment of Agitation in Alzheimer Dementia: Genetic Influences. J Geriatr Psychiatry Neurol. 2016 Mar; 29(2):59-64.