Arthur Charles Riegel

Title
InstitutionMedical University of South Carolina
DepartmentNeuroscience
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    Research Interests:
    Our laboratory is interested in dopamine for its broad role in motor and motivational systems including cognition, attention and learning. We use experimental approaches in animals to investigate the synaptic brain circuitry tuned to support these behaviors. We also investigate the related neuroadaptive changes (synaptic plasticity), which may underlie prevalent diseases such as Parkinson's disease, psychosis, schizophrenia, and Tourette's syndrome.

    Addiction is a disease of abnormal habits or learned behaviors, Researching addiction provides unique insights into the mechanisms underlying learning and how they influence addictive behavior. Virtually all drugs of abuse, including cocaine, amphetamine, heroin and other opiates, alcohol, nicotine and volatile solvents activate dopaminergic systems in the brain. Current research in our laboratory utilizes in vitro electrophysiology (whole cell patch clamp), calcium neuroimaging and uncaging (flash photolysis) in combination with behavioral self-administration to better understand the role of dopamine in normal and abnormal brain function.
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    Neuroscience of addiction & disease, synaptic physiology & receptor pharmacology, cell biology & neuronal signaling

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Vizcarra VS, Barber KR, Franca-Solomon G, Majuta L, Smith A, Langlais PR, Largent-Milnes TM, Vanderah TW, Riegel AC. Targeting 5-HT2A receptors and Kv7 channels in PFC to attenuate chronic neuropathic pain in rats using a spared nerve injury model. Neurosci Lett. 2022 10 15; 789:136864. PMID: 36063980.
      Citations:    Fields:    Translation:Animals
    2. Buchta WC, Moutal A, Hines B, Garcia-Keller C, Smith ACW, Kalivas P, Khanna R, Riegel AC, Buchta WC, Moutal A, Hines B, Garcia-Keller C, Smith ACW, Kalivas P, Khanna R, Riegel AC. Dynamic CRMP2 Regulation of CaV2.2 in the Prefrontal Cortex Contributes to the Reinstatement of Cocaine Seeking. Mol Neurobiol. 2020 Jan; 57(1):346-357. PMID: 31359322; PMCID: PMC6980501.
      Citations:    
    3. Mahler SV, Brodnik ZD, Cox BM, Buchta WC, Bentzley BS, Quintanilla J, Cope ZA, Lin EC, Riedy MD, Scofield MD, Messinger J, Ruiz CM, Riegel AC, España RA, Aston-Jones G, Mahler SV, Brodnik ZD, Cox BM, Buchta WC, Bentzley BS, Quintanilla J, Cope ZA, Lin EC, Riedy MD, Scofield MD, Messinger J, Ruiz CM, Riegel AC, Espa?a RA, Aston-Jones G. Chemogenetic Manipulations of Ventral Tegmental Area Dopamine Neurons Reveal Multifaceted Roles in Cocaine Abuse. J Neurosci. 2019 01 16; 39(3):503-518. PMID: 30446532; PMCID: PMC6335749.
      Citations:    
    4. Harlan BA, Becker HC, Woodward JJ, Riegel AC, Harlan BA, Becker HC, Woodward JJ, Riegel AC. Opposing actions of CRF-R1 and CB1 receptors on VTA-GABAergic plasticity following chronic exposure to ethanol. Neuropsychopharmacology. 2018 09; 43(10):2064-2074. PMID: 29946104; PMCID: PMC6098046.
      Citations:    
    5. Parrilla-Carrero J, Buchta WC, Goswamee P, Culver O, McKendrick G, Harlan B, Moutal A, Penrod R, Lauer A, Ramakrishnan V, Khanna R, Kalivas P, Riegel AC, Parrilla-Carrero J, Buchta WC, Goswamee P, Culver O, McKendrick G, Harlan B, Moutal A, Penrod R, Lauer A, Ramakrishnan V, Khanna R, Kalivas P, Riegel AC. Restoration of Kv7 Channel-Mediated Inhibition Reduces Cued-Reinstatement of Cocaine Seeking. J Neurosci. 2018 04 25; 38(17):4212-4229. PMID: 29636392; PMCID: PMC5963852.
      Citations:    
    6. Buchta WC, Mahler SV, Harlan B, Aston-Jones GS, Riegel AC, Buchta WC, Mahler SV, Harlan B, Aston-Jones GS, Riegel AC. Dopamine terminals from the ventral tegmental area gate intrinsic inhibition in the prefrontal cortex. Physiol Rep. 2017 Mar; 5(6). PMID: 28325790; PMCID: PMC5371565.
      Citations:    
    7. Buchta WC, Riegel AC, Buchta WC, Riegel AC. Chronic cocaine disrupts mesocortical learning mechanisms. Brain Res. 2015 Dec 02; 1628(Pt A):88-103. PMID: 25704202; PMCID: PMC4739740.
      Citations:    
    8. Williams CL, Buchta WC, Riegel AC, Williams CL, Buchta WC, Riegel AC. CRF-R2 and the heterosynaptic regulation of VTA glutamate during reinstatement of cocaine seeking. J Neurosci. 2014 Jul 30; 34(31):10402-14. PMID: 25080599; PMCID: PMC4115144.
      Citations:    
    9. Moussawi K, Riegel A, Nair S, Kalivas PW, Moussawi K, Riegel A, Nair S, Kalivas PW. Extracellular glutamate: functional compartments operate in different concentration ranges. Front Syst Neurosci. 2011; 5:94. PMID: 22275885; PMCID: PMC3254064.
      Citations:    
    10. Riegel AC, Kalivas PW, Riegel AC, Kalivas PW. Neuroscience: Lack of inhibition leads to abuse. Nature. 2010 Feb 11; 463(7282):743-4. PMID: 20148025; PMCID: PMC6451657.
      Citations:    
    11. Riegel AC, Williams JT, Riegel AC, Williams JT. CRF facilitates calcium release from intracellular stores in midbrain dopamine neurons. Neuron. 2008 Feb 28; 57(4):559-70. PMID: 18304485; PMCID: PMC2696265.
      Citations:    
    12. Riegel AC, Zapata A, Shippenberg TS, French ED, Riegel AC, Zapata A, Shippenberg TS, French ED. The abused inhalant toluene increases dopamine release in the nucleus accumbens by directly stimulating ventral tegmental area neurons. Neuropsychopharmacology. 2007 Jul; 32(7):1558-69. PMID: 17213847.
      Citations:    
    13. Lupica CR, Riegel AC, Lupica CR, Riegel AC. Endocannabinoid release from midbrain dopamine neurons: a potential substrate for cannabinoid receptor antagonist treatment of addiction. Neuropharmacology. 2005 Jun; 48(8):1105-16. PMID: 15878779.
      Citations:    
    14. Riegel AC, Lupica CR, Riegel AC, Lupica CR. Independent presynaptic and postsynaptic mechanisms regulate endocannabinoid signaling at multiple synapses in the ventral tegmental area. J Neurosci. 2004 Dec 08; 24(49):11070-8. PMID: 15590923; PMCID: PMC4857882.
      Citations:    
    15. Riegel AC, Ali SF, Torinese S, French ED, Riegel AC, Ali SF, Torinese S, French ED. Repeated exposure to the abused inhalant toluene alters levels of neurotransmitters and generates peroxynitrite in nigrostriatal and mesolimbic nuclei in rat. Ann N Y Acad Sci. 2004 Oct; 1025:543-51. PMID: 15542760.
      Citations:    
    16. Lupica CR, Riegel AC, Hoffman AF, Lupica CR, Riegel AC, Hoffman AF. Marijuana and cannabinoid regulation of brain reward circuits. Br J Pharmacol. 2004 Sep; 143(2):227-34. PMID: 15313883; PMCID: PMC1575338.
      Citations:    
    17. Hoffman AF, Riegel AC, Lupica CR, Hoffman AF, Riegel AC, Lupica CR. Functional localization of cannabinoid receptors and endogenous cannabinoid production in distinct neuron populations of the hippocampus. Eur J Neurosci. 2003 Aug; 18(3):524-34. PMID: 12911748.
      Citations: 35     Fields:    Translation:AnimalsCells
    18. Riegel AC, Ali SF, French ED, Riegel AC, Ali SF, French ED. Toluene-induced locomotor activity is blocked by 6-hydroxydopamine lesions of the nucleus accumbens and the mGluR2/3 agonist LY379268. Neuropsychopharmacology. 2003 Aug; 28(8):1440-7. PMID: 12784113.
      Citations: 21     Fields:    Translation:Animals
    19. Riegel AC, French ED, Riegel AC, French ED. Abused inhalants and central reward pathways: electrophysiological and behavioral studies in the rat. Ann N Y Acad Sci. 2002 Jun; 965:281-91. PMID: 12105104.
      Citations: 17     Fields:    Translation:AnimalsCells
    20. Riegel AC, French ED, Riegel AC, French ED. The susceptibility of rat non-dopamine ventral tegmental neurones to inhibition during toluene exposure. Pharmacol Toxicol. 1999 Jul; 85(1):44-6. PMID: 10426163.
      Citations: 1     Fields:    Translation:AnimalsCells
    21. Riegel AC, French ED, Riegel AC, French ED. An electrophysiological analysis of rat ventral tegmental dopamine neuronal activity during acute toluene exposure. Pharmacol Toxicol. 1999 Jul; 85(1):37-43. PMID: 10426162.
      Citations: 12     Fields:    Translation:AnimalsCells
    22. Riegel AC, French ED, Riegel AC, French ED. Acute toluene induces biphasic changes in rat spontaneous locomotor activity which are blocked by remoxipride. Pharmacol Biochem Behav. 1999 Mar; 62(3):399-402. PMID: 10080229.
      Citations: 18     Fields:    Translation:Animals
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