Michael D. Scofield

Title
InstitutionMedical University of South Carolina
DepartmentAnesthesia and Perioperative Medicine
AddressCRI 204G
Children's Research Inst. - 173 Ashley Ave.
Phone843-792-1743
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hughes BW, Siemsen BM, Tsvetkov E, Berto S, Kumar J, Cornbrooks RG, Akiki RM, Cho JY, Carter JS, Snyder KK, Assali A, Scofield MD, Cowan CW, Taniguchi M. NPAS4 in the medial prefrontal cortex mediates chronic social defeat stress-induced anhedonia-like behavior and reductions in excitatory synapses. Elife. 2023 02 13; 12. PMID: 36780219; PMCID: PMC9925055.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Obray JD, Landin JD, Vaughan DT, Scofield MD, Chandler LJ. Adolescent alcohol exposure reduces dopamine 1 receptor modulation of prelimbic neurons projecting to the nucleus accumbens and basolateral amygdala. Addict Neurosci. 2022 Dec; 4. PMID: 36643604; PMCID: PMC9836047.
      Citations: 2     
    3. Vollmer KM, Green LM, Grant RI, Winston KT, Doncheck EM, Bowen CW, Paniccia JE, Clarke RE, Tiller A, Siegler PN, Bordieanu B, Siemsen BM, Denton AR, Westphal AM, Jhou TC, Rinker JA, McGinty JF, Scofield MD, Otis JM. An opioid-gated thalamoaccumbal circuit for the suppression of reward seeking in mice. Nat Commun. 2022 Nov 11; 13(1):6865. PMID: 36369508; PMCID: PMC9652456.
      Citations: 2     Fields:    Translation:Animals
    4. Healey KL, Bell A, Scofield MD, Swartzwelder HS. Adolescent intermittent ethanol exposure reduces astrocyte-synaptic proximity in the adult medial prefrontal cortex in rats: Reversal by gabapentin. Addict Neurosci. 2022 Dec; 4. PMID: 36643603; PMCID: PMC9836051.
      Citations:    
    5. Paniccia JE, Otis JM, Scofield MD. Looking to the stars for answers: Strategies for determining how astrocytes influence neuronal activity. Comput Struct Biotechnol J. 2022; 20:4146-4156. PMID: 36016711; PMCID: PMC9379862.
      Citations: 2     
    6. Kruyer A, Kalivas PW, Scofield MD, Kruyer A, Kalivas PW, Scofield MD. Astrocyte regulation of synaptic signaling in psychiatric disorders. Neuropsychopharmacology. 2023 01; 48(1):21-36. PMID: 35577914; PMCID: PMC9700696.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    7. Siemsen BM, Barry SM, Vollmer KM, Green LM, Brock AG, Westphal AM, King RA, DeVries DM, Otis JM, Cowan CW, Scofield MD, Siemsen BM, Barry SM, Vollmer KM, Green LM, Brock AG, Westphal AM, King RA, DeVries DM, Otis JM, Cowan CW, Scofield MD. A Subset of Nucleus Accumbens Neurons Receiving Dense and Functional Prelimbic Cortical Input Are Required for Cocaine Seeking. Front Cell Neurosci. 2022; 16:844243. PMID: 35281297; PMCID: PMC8907444.
      Citations:    
    8. Kearns AM, Siemsen BM, Hopkins JL, Weber RA, Scofield MD, Peters J, Reichel CM, Kearns AM, Siemsen BM, Hopkins JL, Weber RA, Scofield MD, Peters J, Reichel CM. Chemogenetic inhibition of corticostriatal circuits reduces cued reinstatement of methamphetamine seeking. Addict Biol. 2022 01; 27(1):e13097. PMID: 34431593; PMCID: PMC8809357.
      Citations:    
    9. Gipson CD, Rawls S, Scofield MD, Siemsen BM, Bondy EO, Maher EE, Gipson CD, Rawls S, Scofield MD, Siemsen BM, Bondy EO, Maher EE. Interactions of neuroimmune signaling and glutamate plasticity in addiction. J Neuroinflammation. 2021 Feb 21; 18(1):56. PMID: 33612110; PMCID: PMC7897396.
      Citations:    
    10. Siemsen BM, Scofield MD, Siemsen BM, Scofield MD. Quiet on the Set! Astroglia Star in Silent Synaptogenesis and Cocaine Memory Formation. Biol Psychiatry. 2021 02 15; 89(4):328-330. PMID: 33478681; PMCID: PMC9063466.
      Citations:    
    11. Leyrer-Jackson JM, Holter M, Overby PF, Newbern JM, Scofield MD, Olive MF, Gipson CD, Leyrer-Jackson JM, Holter M, Overby PF, Newbern JM, Scofield MD, Olive MF, Gipson CD. Accumbens Cholinergic Interneurons Mediate Cue-Induced Nicotine Seeking and Associated Glutamatergic Plasticity. eNeuro. 2021 Jan-Feb; 8(1). PMID: 33239269; PMCID: PMC7890519.
      Citations:    
    12. Kruyer A, Scofield MD, Kruyer A, Scofield MD. Astrocytes in Addictive Disorders. Adv Neurobiol. 2021; 26:231-254. PMID: 34888837; PMCID: PMC9060395.
      Citations:    
    13. Chioma VC, Kruyer A, Bobadilla AC, Angelis A, Ellison Z, Hodebourg R, Scofield MD, Kalivas PW, Chioma VC, Kruyer A, Bobadilla AC, Angelis A, Ellison Z, Hodebourg R, Scofield MD, Kalivas PW. Heroin Seeking and Extinction From Seeking Activate Matrix Metalloproteinases at Synapses on Distinct Subpopulations of Accumbens Cells. Biol Psychiatry. 2021 05 15; 89(10):947-958. PMID: 33579535; PMCID: PMC8434769.
      Citations:    
    14. Garcia-Keller C, Scofield MD, Neuhofer D, Varanasi S, Reeves MT, Hughes B, Anderson E, Richie CT, Mejias-Aponte C, Pickel J, Hope BT, Harvey BK, Cowan CW, Kalivas PW, Garcia-Keller C, Scofield MD, Neuhofer D, Varanasi S, Reeves MT, Hughes B, Anderson E, Richie CT, Mejias-Aponte C, Pickel J, Hope BT, Harvey BK, Cowan CW, Kalivas PW. Relapse-Associated Transient Synaptic Potentiation Requires Integrin-Mediated Activation of Focal Adhesion Kinase and Cofilin in D1-Expressing Neurons. J Neurosci. 2020 10 28; 40(44):8463-8477. PMID: 33051346; PMCID: PMC7605418.
      Citations:    
    15. Bobadilla AC, Dereschewitz E, Vaccaro L, Heinsbroek JA, Scofield MD, Kalivas PW, Bobadilla AC, Dereschewitz E, Vaccaro L, Heinsbroek JA, Scofield MD, Kalivas PW. Cocaine and sucrose rewards recruit different seeking ensembles in the nucleus accumbens core. Mol Psychiatry. 2020 12; 25(12):3150-3163. PMID: 32985600; PMCID: PMC8532193.
      Citations:    
    16. Healey KL, Kibble S, Hodges S, Reissner KJ, Testen A, Wills TA, Acheson SK, Siemsen BM, McFaddin JA, Scofield MD, Swartzwelder HS, Healey KL, Kibble S, Hodges S, Reissner KJ, Testen A, Wills TA, Acheson SK, Siemsen BM, McFaddin JA, Scofield MD, Swartzwelder HS. Enduring alterations in hippocampal astrocytesynaptic proximity following adolescent alcohol exposure: reversal by gabapentin. Neural Regen Res. 2020 Aug; 15(8):1496-1501. PMID: 31997814; PMCID: PMC7059577.
      Citations:    
    17. Siemsen BM, Landin JD, McFaddin JA, Hooker KN, Chandler LJ, Scofield MD, Siemsen BM, Landin JD, McFaddin JA, Hooker KN, Chandler LJ, Scofield MD. Chronic intermittent ethanol and lipopolysaccharide exposure differentially alter Iba1-derived microglia morphology in the prelimbic cortex and nucleus accumbens core of male Long-Evans rats. J Neurosci Res. 2021 08; 99(8):1922-1939. PMID: 32621337; PMCID: PMC7779701.
      Citations:    
    18. Harrington AJ, Bridges CM, Berto S, Blankenship K, Cho JY, Assali A, Siemsen BM, Moore HW, Tsvetkov E, Thielking A, Konopka G, Everman DB, Scofield MD, Skinner SA, Cowan CW, Harrington AJ, Bridges CM, Berto S, Blankenship K, Cho JY, Assali A, Siemsen BM, Moore HW, Tsvetkov E, Thielking A, Konopka G, Everman DB, Scofield MD, Skinner SA, Cowan CW. MEF2C Hypofunction in Neuronal and Neuroimmune Populations Produces MEF2C Haploinsufficiency Syndrome-like Behaviors in Mice. Biol Psychiatry. 2020 09 15; 88(6):488-499. PMID: 32418612; PMCID: PMC7483399.
      Citations:    
    19. Siemsen BM, McFaddin JA, Haigh K, Brock AG, Nan Leath M, Hooker KN, McGonegal LK, Scofield MD, Siemsen BM, McFaddin JA, Haigh K, Brock AG, Nan Leath M, Hooker KN, McGonegal LK, Scofield MD. Amperometric measurements of cocaine cue and novel context-evoked glutamate and nitric oxide release in the nucleus accumbens core. J Neurochem. 2020 06; 153(5):599-616. PMID: 31901130; PMCID: PMC7593647.
      Citations:    
    20. Kruyer A, Scofield MD, Wood D, Reissner KJ, Kalivas PW, Kruyer A, Scofield MD, Wood D, Reissner KJ, Kalivas PW. Heroin Cue-Evoked Astrocytic Structural Plasticity at Nucleus Accumbens Synapses Inhibits Heroin Seeking. Biol Psychiatry. 2019 12 01; 86(11):811-819. PMID: 31495448; PMCID: PMC6823145.
      Citations:    
    21. Mahler SV, Brodnik ZD, Cox BM, Buchta WC, Bentzley BS, Quintanilla J, Cope ZA, Lin EC, Riedy MD, Scofield MD, Messinger J, Ruiz CM, Riegel AC, España RA, Aston-Jones G, Mahler SV, Brodnik ZD, Cox BM, Buchta WC, Bentzley BS, Quintanilla J, Cope ZA, Lin EC, Riedy MD, Scofield MD, Messinger J, Ruiz CM, Riegel AC, Espa?a RA, Aston-Jones G. Chemogenetic Manipulations of Ventral Tegmental Area Dopamine Neurons Reveal Multifaceted Roles in Cocaine Abuse. J Neurosci. 2019 01 16; 39(3):503-518. PMID: 30446532; PMCID: PMC6335749.
      Citations:    
    22. Peters J, Scofield MD, Reichel CM, Peters J, Scofield MD, Reichel CM. Chemogenetic activation of the perirhinal cortex reverses methamphetamine-induced memory deficits and reduces relapse. Learn Mem. 2018 09; 25(9):410-415. PMID: 30115762; PMCID: PMC6097768.
      Citations:    
    23. Spencer S, Neuhofer D, Chioma VC, Garcia-Keller C, Schwartz DJ, Allen N, Scofield MD, Ortiz-Ithier T, Kalivas PW, Spencer S, Neuhofer D, Chioma VC, Garcia-Keller C, Schwartz DJ, Allen N, Scofield MD, Ortiz-Ithier T, Kalivas PW. A Model of ?9-Tetrahydrocannabinol Self-administration and Reinstatement That Alters Synaptic Plasticity in Nucleus Accumbens. Biol Psychiatry. 2018 10 15; 84(8):601-610. PMID: 29861097; PMCID: PMC6162175.
      Citations:    
    24. Scofield MD, Scofield MD. Exploring the Role of Astroglial Glutamate Release and Association With Synapses in Neuronal Function and Behavior. Biol Psychiatry. 2018 12 01; 84(11):778-786. PMID: 29258653; PMCID: PMC5948108.
      Citations:    
    25. Bobadilla AC, Garcia-Keller C, Heinsbroek JA, Scofield MD, Chareunsouk V, Monforton C, Kalivas PW, Bobadilla AC, Garcia-Keller C, Heinsbroek JA, Scofield MD, Chareunsouk V, Monforton C, Kalivas PW. Accumbens Mechanisms for Cued Sucrose Seeking. Neuropsychopharmacology. 2017 Nov; 42(12):2377-2386. PMID: 28726801; PMCID: PMC5645741.
      Citations:    
    26. Scofield MD, Scofield MD. Similitude in Methamphetamine-Induced Neuroadaptations Across Susceptibility and Chronic Drug Exposure Paradigms. Biol Psychiatry. 2017 06 01; 81(11):e83-e84. PMID: 28502394; PMCID: PMC6459405.
      Citations:    
    27. Smith ACW, Scofield MD, Heinsbroek JA, Gipson CD, Neuhofer D, Roberts-Wolfe DJ, Spencer S, Garcia-Keller C, Stankeviciute NM, Smith RJ, Allen NP, Lorang MR, Griffin WC, Boger HA, Kalivas PW, Smith ACW, Scofield MD, Heinsbroek JA, Gipson CD, Neuhofer D, Roberts-Wolfe DJ, Spencer S, Garcia-Keller C, Stankeviciute NM, Smith RJ, Allen NP, Lorang MR, Griffin WC, Boger HA, Kalivas PW. Accumbens nNOS Interneurons Regulate Cocaine Relapse. J Neurosci. 2017 01 25; 37(4):742-756. PMID: 28123012; PMCID: PMC5296777.
      Citations:    
    28. Scofield MD, Heinsbroek JA, Gipson CD, Kupchik YM, Spencer S, Smith AC, Roberts-Wolfe D, Kalivas PW, Scofield MD, Heinsbroek JA, Gipson CD, Kupchik YM, Spencer S, Smith AC, Roberts-Wolfe D, Kalivas PW. The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis. Pharmacol Rev. 2016 07; 68(3):816-71. PMID: 27363441; PMCID: PMC4931870.
      Citations:    
    29. Spencer S, Scofield M, Kalivas PW, Spencer S, Scofield M, Kalivas PW. The good and bad news about glutamate in drug addiction. J Psychopharmacol. 2016 11; 30(11):1095-1098. PMID: 27353027; PMCID: PMC5234332.
      Citations:    
    30. Scofield MD, Li H, Siemsen BM, Healey KL, Tran PK, Woronoff N, Boger HA, Kalivas PW, Reissner KJ, Scofield MD, Li H, Siemsen BM, Healey KL, Tran PK, Woronoff N, Boger HA, Kalivas PW, Reissner KJ. Cocaine Self-Administration and Extinction Leads to Reduced Glial Fibrillary Acidic Protein Expression and Morphometric Features of Astrocytes in the Nucleus Accumbens Core. Biol Psychiatry. 2016 08 01; 80(3):207-15. PMID: 26946381; PMCID: PMC4930433.
      Citations:    
    31. Peters J, Scofield MD, Ghee SM, Heinsbroek JA, Reichel CM, Peters J, Scofield MD, Ghee SM, Heinsbroek JA, Reichel CM. Perirhinal Cortex mGlu5 Receptor Activation Reduces Relapse to Methamphetamine Seeking by Restoring Novelty Salience. Neuropsychopharmacology. 2016 May; 41(6):1477-85. PMID: 26365953; PMCID: PMC4832007.
      Citations:    
    32. Scofield MD, Trantham-Davidson H, Schwendt M, Leong KC, Peters J, See RE, Reichel CM, Scofield MD, Trantham-Davidson H, Schwendt M, Leong KC, Peters J, See RE, Reichel CM. Failure to Recognize Novelty after Extended Methamphetamine Self-Administration Results from Loss of Long-Term Depression in the Perirhinal Cortex. Neuropsychopharmacology. 2015 Oct; 40(11):2526-35. PMID: 25865928; PMCID: PMC4569960.
      Citations:    
    33. Smith AC, Scofield MD, Kalivas PW, Smith AC, Scofield MD, Kalivas PW. The tetrapartite synapse: Extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction. Brain Res. 2015 Dec 02; 1628(Pt A):29-39. PMID: 25838241; PMCID: PMC4589426.
      Citations:    
    34. Scofield MD, Boger HA, Smith RJ, Li H, Haydon PG, Kalivas PW, Scofield MD, Boger HA, Smith RJ, Li H, Haydon PG, Kalivas PW. Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking. Biol Psychiatry. 2015 Oct 01; 78(7):441-51. PMID: 25861696; PMCID: PMC4547911.
      Citations:    
    35. Farrand AQ, Gregory RA, Scofield MD, Helke KL, Boger HA, Farrand AQ, Gregory RA, Scofield MD, Helke KL, Boger HA. Effects of aging on glutamate neurotransmission in the substantia nigra of Gdnf heterozygous mice. Neurobiol Aging. 2015 Mar; 36(3):1569-76. PMID: 25577412; PMCID: PMC4346478.
      Citations:    
    36. Hogan EM, Casserly AP, Scofield MD, Mou Z, Zhao-Shea R, Johnson CW, Tapper AR, Gardner PD, Hogan EM, Casserly AP, Scofield MD, Mou Z, Zhao-Shea R, Johnson CW, Tapper AR, Gardner PD. miRNAome analysis of the mammalian neuronal nicotinic acetylcholine receptor gene family. RNA. 2014 Dec; 20(12):1890-9. PMID: 25344397; PMCID: PMC4238110.
      Citations:    
    37. Smith AC, Kupchik YM, Scofield MD, Gipson CD, Wiggins A, Thomas CA, Kalivas PW, Smith AC, Kupchik YM, Scofield MD, Gipson CD, Wiggins A, Thomas CA, Kalivas PW. Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases. Nat Neurosci. 2014 Dec; 17(12):1655-7. PMID: 25326689; PMCID: PMC4241163.
      Citations:    
    38. Shen HW, Scofield MD, Boger H, Hensley M, Kalivas PW, Shen HW, Scofield MD, Boger H, Hensley M, Kalivas PW. Synaptic glutamate spillover due to impaired glutamate uptake mediates heroin relapse. J Neurosci. 2014 Apr 16; 34(16):5649-57. PMID: 24741055; PMCID: PMC3988415.
      Citations:    
    39. Reissner KJ, Gipson CD, Tran PK, Knackstedt LA, Scofield MD, Kalivas PW, Reissner KJ, Gipson CD, Tran PK, Knackstedt LA, Scofield MD, Kalivas PW. Glutamate transporter GLT-1 mediates N-acetylcysteine inhibition of cocaine reinstatement. Addict Biol. 2015 Mar; 20(2):316-23. PMID: 24612076; PMCID: PMC4437505.
      Citations:    
    40. Scofield MD, Kalivas PW, Scofield MD, Kalivas PW. Astrocytic dysfunction and addiction: consequences of impaired glutamate homeostasis. Neuroscientist. 2014 Dec; 20(6):610-22. PMID: 24496610; PMCID: PMC4913887.
      Citations:    
    41. Kupchik YM, Scofield MD, Rice KC, Cheng K, Roques BP, Kalivas PW, Kupchik YM, Scofield MD, Rice KC, Cheng K, Roques BP, Kalivas PW. Cocaine dysregulates opioid gating of GABA neurotransmission in the ventral pallidum. J Neurosci. 2014 Jan 15; 34(3):1057-66. PMID: 24431463; PMCID: PMC3891949.
      Citations:    
    42. Stankeviciute NM, Scofield MD, Kalivas PW, Gipson CD, Stankeviciute NM, Scofield MD, Kalivas PW, Gipson CD. Rapid, transient potentiation of dendritic spines in context-induced relapse to cocaine seeking. Addict Biol. 2014 Nov; 19(6):972-4. PMID: 23648005; PMCID: PMC3742620.
      Citations:    
    43. Scofield MD, Kalivas PW, Scofield MD, Kalivas PW. Forgiving the sins of the fathers. Nat Neurosci. 2013 Jan; 16(1):4-5. PMID: 23257926; PMCID: PMC4913885.
      Citations:    
    44. Scofield MD, Korutla L, Jackson TG, Kalivas PW, Mackler SA, Scofield MD, Korutla L, Jackson TG, Kalivas PW, Mackler SA. Nucleus Accumbens 1, a Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad protein binds to TAR DNA-binding protein 43 and has a potential role in Amyotrophic Lateral Sclerosis. Neuroscience. 2012 Dec 27; 227:44-54. PMID: 23022214; PMCID: PMC3505276.
      Citations:    
    45. Improgo MR, Scofield MD, Tapper AR, Gardner PD, Improgo MR, Scofield MD, Tapper AR, Gardner PD. The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer. Prog Neurobiol. 2010 Oct; 92(2):212-26. PMID: 20685379; PMCID: PMC2939268.
      Citations:    
    46. Scofield MD, Brüschweiler-Li L, Mou Z, Gardner PD, Scofield MD, Br?schweiler-Li L, Mou Z, Gardner PD. Transcription factor assembly on the nicotinic receptor beta4 subunit gene promoter. Neuroreport. 2008 Apr 16; 19(6):687-90. PMID: 18382288; PMCID: PMC7656899.
      Citations:    
    Scofield's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (186)
    Explore
    _
    Co-Authors (24)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _