5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-alpha-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cells.

5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-alpha-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cells. J Biol Chem. 2006 Jul 28; 281(30):21004-21012.

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subject areas

ADAM Proteins
ADAM17 Protein
Animals
Cell Proliferation
Cells, Cultured
Epidermal Growth Factor
Extracellular Signal-Regulated MAP Kinases
Heparin
Heparin-binding EGF-like Growth Factor
Intercellular Signaling Peptides and Proteins
Mesangial Cells
Phosphorylation
Rats
Receptor, Serotonin, 5-HT2A
Transcriptional Activation

authors with profiles

Monika Gooz
Louis M Luttrell