PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species.

PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species. Mol Cancer Ther. 2016 07; 15(7):1637-47.

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subject areas

Animals
Biphenyl Compounds
Cell Line, Tumor
Cell Proliferation
Cell Survival
Disease Models, Animal
Humans
Hypoxia
Hypoxia-Inducible Factor 1, alpha Subunit
Male
Mice
Models, Biological
Neoplasms
NF-E2-Related Factor 2
Prostatic Neoplasms
Protein Binding
Protein Kinase Inhibitors
Protein Transport
Proto-Oncogene Proteins c-pim-1
Reactive Oxygen Species
Signal Transduction
Thiazolidines
Xenograft Model Antitumor Assays

authors with profiles

Andrew S Kraft