Justin T. Gass

Title
InstitutionMedical University of South Carolina
DepartmentNeuroscience
AddressP.O. Box MSC 861
IOPN 469
67 President St.
Phone843-792-5159
Fax843-792-7353
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    The main focus of Dr. Gass's current research is to determine how glutamate receptors alter the reinforcing properties of alcohol-related cues. Studies from his laboratory have demonstrated that modulation of the mGluR5 receptor can facilitate the extinction of alcohol-seeking behavior, prevent relapse induced by exposure to alcohol cues, and alter both structural and functional plasticity in the prefrontal cortex. Furthermore, his research has shown that blockade of mGluR5 can attenuate the reinforcing properties of alcohol and prevent various forms of alcohol-seeking behavior. Ongoing studies in his laboratory also suggest that the manipulation of alcohol memories during the 'reconsolidation' period can also attenuate alcohol-seeking behavior. These novel findings are being pursued as a possible pharmacological therapy to be used in conjunction with current behavioral therapies for the treatment of alcoholism.
    Collapse keywords
    Addiction, alcohol, glutamate, drug cues, relapse

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chandler LJ, Vaughan DT, Gass JT, Chandler LJ, Vaughan DT, Gass JT. Adolescent Alcohol Exposure Results in Sex-specific Alterations in Conditioned Fear Learning and Memory in Adulthood. Front Pharmacol. 2022; 13:837657. PMID: 35211024; PMCID: PMC8861326.
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    2. Brown RW, Varnum CG, Wills LJ, Peeters LD, Gass JT, Brown RW, Varnum CG, Wills LJ, Peeters LD, Gass JT. Modulation of mGlu5 improves sensorimotor gating deficits in rats neonatally treated with quinpirole through changes in dopamine D2 signaling. Pharmacol Biochem Behav. 2021 12; 211:173292. PMID: 34710401; PMCID: PMC9176413.
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    3. Smiley CE, Saleh HK, Nimchuk KE, Garcia-Keller C, Gass JT, Smiley CE, Saleh HK, Nimchuk KE, Garcia-Keller C, Gass JT. Adolescent exposure to delta-9-tetrahydrocannabinol and ethanol heightens sensitivity to fear stimuli. Behav Brain Res. 2021 10 11; 415:113517. PMID: 34389427; PMCID: PMC8404161.
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    4. Garcia-Keller C, Smiley C, Monforton C, Melton S, Kalivas PW, Gass J, Garcia-Keller C, Smiley C, Monforton C, Melton S, Kalivas PW, Gass J. N-Acetylcysteine treatment during acute stress prevents stress-induced augmentation of addictive drug use and relapse. Addict Biol. 2020 09; 25(5):e12798. PMID: 31282090; PMCID: PMC7439767.
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    5. Macht VA, Kelly SJ, Gass JT, Macht VA, Kelly SJ, Gass JT. Sex-specific effects of developmental alcohol exposure on cocaine-induced place preference in adulthood. Behav Brain Res. 2017 08 14; 332:259-268. PMID: 28600000; PMCID: PMC5570610.
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    6. Cannady R, McGonigal JT, Newsom RJ, Woodward JJ, Mulholland PJ, Gass JT, Cannady R, McGonigal JT, Newsom RJ, Woodward JJ, Mulholland PJ, Gass JT. Prefrontal Cortex KCa2 Channels Regulate mGlu5-Dependent Plasticity and Extinction of Alcohol-Seeking Behavior. J Neurosci. 2017 04 19; 37(16):4359-4369. PMID: 28320841; PMCID: PMC5413180.
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    7. Gass JT, McGonigal JT, Chandler LJ, Gass JT, McGonigal JT, Chandler LJ. Deficits in the extinction of ethanol-seeking behavior following chronic intermittent ethanol exposure are attenuated with positive allosteric modulation of mGlu5. Neuropharmacology. 2017 02; 113(Pt A):198-205. PMID: 27725153; PMCID: PMC5148675.
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    8. Trantham-Davidson H, Centanni SW, Garr SC, New NN, Mulholland PJ, Gass JT, Glover EJ, Floresco SB, Crews FT, Krishnan HR, Pandey SC, Chandler LJ, Trantham-Davidson H, Centanni SW, Garr SC, New NN, Mulholland PJ, Gass JT, Glover EJ, Floresco SB, Crews FT, Krishnan HR, Pandey SC, Chandler LJ. Binge-Like Alcohol Exposure During Adolescence Disrupts Dopaminergic Neurotransmission in the Adult Prelimbic Cortex. Neuropsychopharmacology. 2017 Apr; 42(5):1024-1036. PMID: 27620551; PMCID: PMC5506791.
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    9. McGuier NS, Griffin WC, Gass JT, Padula AE, Chesler EJ, Mulholland PJ, McGuier NS, Griffin WC, Gass JT, Padula AE, Chesler EJ, Mulholland PJ. Kv7 channels in the nucleus accumbens are altered by chronic drinking and are targets for reducing alcohol consumption. Addict Biol. 2016 11; 21(6):1097-1112. PMID: 26104325; PMCID: PMC4689668.
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    10. Olive MF, Gass JT, Olive MF, Gass JT. Editorial: structural plasticity induced by drugs of abuse. Front Pharmacol. 2015; 6:88. PMID: 26029104; PMCID: PMC4432576.
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    11. Uys JD, McGuier NS, Gass JT, Griffin WC, Ball LE, Mulholland PJ, Uys JD, McGuier NS, Gass JT, Griffin WC, Ball LE, Mulholland PJ. Chronic intermittent ethanol exposure and withdrawal leads to adaptations in nucleus accumbens core postsynaptic density proteome and dendritic spines. Addict Biol. 2016 May; 21(3):560-74. PMID: 25787124; PMCID: PMC4573771.
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    12. LaCrosse AL, Taylor SB, Nemirovsky NE, Gass JT, Olive MF, LaCrosse AL, Taylor SB, Nemirovsky NE, Gass JT, Olive MF. mGluR5 Positive and Negative Allosteric Modulators Differentially Affect Dendritic Spine Density and Morphology in the Prefrontal Cortex. CNS Neurol Disord Drug Targets. 2015; 14(4):476-85. PMID: 25921744; PMCID: PMC4507801.
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    13. Gass JT, Trantham-Davidson H, Kassab AS, Glen WB, Olive MF, Chandler LJ, Gass JT, Trantham-Davidson H, Kassab AS, Glen WB, Olive MF, Chandler LJ. Enhancement of extinction learning attenuates ethanol-seeking behavior and alters plasticity in the prefrontal cortex. J Neurosci. 2014 May 28; 34(22):7562-74. PMID: 24872560; PMCID: PMC4035518.
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    14. Gass JT, Glen WB, McGonigal JT, Trantham-Davidson H, Lopez MF, Randall PK, Yaxley R, Floresco SB, Chandler LJ, Gass JT, Glen WB, McGonigal JT, Trantham-Davidson H, Lopez MF, Randall PK, Yaxley R, Floresco SB, Chandler LJ. Adolescent alcohol exposure reduces behavioral flexibility, promotes disinhibition, and increases resistance to extinction of ethanol self-administration in adulthood. Neuropsychopharmacology. 2014 Oct; 39(11):2570-83. PMID: 24820536; PMCID: PMC4207336.
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    15. Trantham-Davidson H, Burnett EJ, Gass JT, Lopez MF, Mulholland PJ, Centanni SW, Floresco SB, Chandler LJ, Trantham-Davidson H, Burnett EJ, Gass JT, Lopez MF, Mulholland PJ, Centanni SW, Floresco SB, Chandler LJ. Chronic alcohol disrupts dopamine receptor activity and the cognitive function of the medial prefrontal cortex. J Neurosci. 2014 Mar 05; 34(10):3706-18. PMID: 24599469; PMCID: PMC3942586.
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    16. Gass JT, Chandler LJ, Gass JT, Chandler LJ. The Plasticity of Extinction: Contribution of the Prefrontal Cortex in Treating Addiction through Inhibitory Learning. Front Psychiatry. 2013; 4:46. PMID: 23750137; PMCID: PMC3667556.
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    17. Kroener S, Mulholland PJ, New NN, Gass JT, Becker HC, Chandler LJ, Kroener S, Mulholland PJ, New NN, Gass JT, Becker HC, Chandler LJ. Chronic alcohol exposure alters behavioral and synaptic plasticity of the rodent prefrontal cortex. PLoS One. 2012; 7(5):e37541. PMID: 22666364; PMCID: PMC3364267.
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    18. Gass JT, Olive MF, Gass JT, Olive MF. Neurochemical and neurostructural plasticity in alcoholism. ACS Chem Neurosci. 2012 Jul 18; 3(7):494-504. PMID: 22896799; PMCID: PMC3419452.
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    19. Sinclair CM, Cleva RM, Hood LE, Olive MF, Gass JT, Sinclair CM, Cleva RM, Hood LE, Olive MF, Gass JT. mGluR5 receptors in the basolateral amygdala and nucleus accumbens regulate cue-induced reinstatement of ethanol-seeking behavior. Pharmacol Biochem Behav. 2012 May; 101(3):329-35. PMID: 22296815; PMCID: PMC3310253.
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    20. Widholm JJ, Gass JT, Cleva RM, Olive MF, Widholm JJ, Gass JT, Cleva RM, Olive MF. The mGluR5 Positive Allosteric Modulator CDPPB Does Not Alter Extinction or Contextual Reinstatement of Methamphetamine-Seeking Behavior in Rats. J Addict Res Ther. 2011 Dec 24; S1(4). PMID: 22428090; PMCID: PMC3305267.
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    21. Cleva RM, Hicks MP, Gass JT, Wischerath KC, Plasters ET, Widholm JJ, Olive MF, Cleva RM, Hicks MP, Gass JT, Wischerath KC, Plasters ET, Widholm JJ, Olive MF. mGluR5 positive allosteric modulation enhances extinction learning following cocaine self-administration. Behav Neurosci. 2011 Feb; 125(1):10-9. PMID: 21319882; PMCID: PMC3073132.
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    22. Cleva RM, Gass JT, Widholm JJ, Olive MF, Cleva RM, Gass JT, Widholm JJ, Olive MF. Glutamatergic targets for enhancing extinction learning in drug addiction. Curr Neuropharmacol. 2010 Dec; 8(4):394-408. PMID: 21629446; PMCID: PMC3080595.
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    23. Gass JT, Sinclair CM, Cleva RM, Widholm JJ, Olive MF, Gass JT, Sinclair CM, Cleva RM, Widholm JJ, Olive MF. Alcohol-seeking behavior is associated with increased glutamate transmission in basolateral amygdala and nucleus accumbens as measured by glutamate-oxidase-coated biosensors. Addict Biol. 2011 Apr; 16(2):215-28. PMID: 21054692; PMCID: PMC3058760.
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    24. Arolfo MP, Overstreet DH, Yao L, Fan P, Lawrence AJ, Tao G, Keung WM, Vallee BL, Olive MF, Gass JT, Rubin E, Anni H, Hodge CW, Besheer J, Zablocki J, Leung K, Blackburn BK, Lange LG, Diamond I, Arolfo MP, Overstreet DH, Yao L, Fan P, Lawrence AJ, Tao G, Keung WM, Vallee BL, Olive MF, Gass JT, Rubin E, Anni H, Hodge CW, Besheer J, Zablocki J, Leung K, Blackburn BK, Lange LG, Diamond I. Suppression of heavy drinking and alcohol seeking by a selective ALDH-2 inhibitor. Alcohol Clin Exp Res. 2009 Nov; 33(11):1935-44. PMID: 19673742; PMCID: PMC8212937.
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    25. Gass JT, Olive MF, Gass JT, Olive MF. Role of protein kinase C epsilon (PKCvarepsilon) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell. Psychopharmacology (Berl). 2009 Jul; 204(4):587-97. PMID: 19225761; PMCID: PMC2766924.
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    26. Moussawi K, Pacchioni A, Moran M, Olive MF, Gass JT, Lavin A, Kalivas PW, Moussawi K, Pacchioni A, Moran M, Olive MF, Gass JT, Lavin A, Kalivas PW. N-Acetylcysteine reverses cocaine-induced metaplasticity. Nat Neurosci. 2009 Feb; 12(2):182-9. PMID: 19136971; PMCID: PMC2661026.
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    27. Gass JT, Olive MF, Gass JT, Olive MF. Positive allosteric modulation of mGluR5 receptors facilitates extinction of a cocaine contextual memory. Biol Psychiatry. 2009 Apr 15; 65(8):717-20. PMID: 19100966; PMCID: PMC2870714.
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    28. Gass JT, Osborne MP, Watson NL, Brown JL, Olive MF, Gass JT, Osborne MP, Watson NL, Brown JL, Olive MF. mGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in rats. Neuropsychopharmacology. 2009 Mar; 34(4):820-33. PMID: 18800068; PMCID: PMC2669746.
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    29. Burattini C, McGeehan AJ, Griffin WC, Gass JT, Kinder JR, Janak PH, Olive MF, Burattini C, McGeehan AJ, Griffin WC, Gass JT, Kinder JR, Janak PH, Olive MF. A microdialysis study of extracellular levels of acamprosate and naltrexone in the rat brain following acute and repeated administration. Addict Biol. 2008 Mar; 13(1):70-9. PMID: 18269381.
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    30. Gass JT, Olive MF, Gass JT, Olive MF. Transcriptional profiling of the rat frontal cortex following administration of the mGlu5 receptor antagonists MPEP and MTEP. Eur J Pharmacol. 2008 Apr 28; 584(2-3):253-62. PMID: 18346726; PMCID: PMC2386089.
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    31. Gass JT, Jenkins WJ, Marino MD, Lugo JN, Kelly SJ, Gass JT, Jenkins WJ, Marino MD, Lugo JN, Kelly SJ. Alcohol exposure during development: analysis of effects on female sexual behavior. Alcohol Clin Exp Res. 2007 Dec; 31(12):2065-72. PMID: 17949467.
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    32. Bowers MS, Chen BT, Chou JK, Osborne MP, Gass JT, See RE, Bonci A, Janak PH, Olive MF, Bowers MS, Chen BT, Chou JK, Osborne MP, Gass JT, See RE, Bonci A, Janak PH, Olive MF. Acamprosate attenuates cocaine- and cue-induced reinstatement of cocaine-seeking behavior in rats. Psychopharmacology (Berl). 2007 Dec; 195(3):397-406. PMID: 17764007.
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    33. Orr RK, Hoehn JL, Col NF, Gass JT, Olive MF. Reinstatement of ethanol-seeking behavior following intravenous self-administration in Wistar rats. Alcohol Clin Exp Res. 2007 Sep; 31(9):1441-5. PMID: 17666107.
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    34. Gass JT, Olive MF, Gass JT, Olive MF. Glutamatergic substrates of drug addiction and alcoholism. Biochem Pharmacol. 2008 Jan 01; 75(1):218-65. PMID: 17706608; PMCID: PMC2239014.
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    35. Grillo CA, Tamashiro KL, Piroli GG, Melhorn S, Gass JT, Newsom RJ, Reznikov LR, Smith A, Wilson SP, Sakai RR, Reagan LP, Grillo CA, Tamashiro KL, Piroli GG, Melhorn S, Gass JT, Newsom RJ, Reznikov LR, Smith A, Wilson SP, Sakai RR, Reagan LP. Lentivirus-mediated downregulation of hypothalamic insulin receptor expression. Physiol Behav. 2007 Nov 23; 92(4):691-701. PMID: 17585961; PMCID: PMC2129218.
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    36. Lugo JN, Marino MD, Gass JT, Wilson MA, Kelly SJ, Lugo JN, Marino MD, Gass JT, Wilson MA, Kelly SJ. Ethanol exposure during development reduces resident aggression and testosterone in rats. Physiol Behav. 2006 Feb 28; 87(2):330-7. PMID: 16336982; PMCID: PMC3589998.
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    37. Brown RW, Gass JT, Kostrzewa RM, Brown RW, Gass JT, Kostrzewa RM. Ontogenetic quinpirole treatments produce spatial memory deficits and enhance skilled reaching in adult rats. Pharmacol Biochem Behav. 2002 Jun; 72(3):591-600. PMID: 12175456.
      Citations: 11     Fields:    Translation:Animals
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