Receptor, Metabotropic Glutamate 5
"Receptor, Metabotropic Glutamate 5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A type I G protein-coupled receptor mostly expressed post-synaptic pyramidal cells of the cortex and CENTRAL NERVOUS SYSTEM.
| Descriptor ID |
D064529
|
| MeSH Number(s) |
D12.776.543.750.695.450.500 D12.776.543.750.720.200.450.500.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Receptor, Metabotropic Glutamate 5".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, G-Protein-Coupled [D12.776.543.750.695]
- Receptors, Metabotropic Glutamate [D12.776.543.750.695.450]
- Receptor, Metabotropic Glutamate 5 [D12.776.543.750.695.450.500]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Amino Acid [D12.776.543.750.720.200]
- Receptors, Glutamate [D12.776.543.750.720.200.450]
- Receptors, Metabotropic Glutamate [D12.776.543.750.720.200.450.500]
- Receptor, Metabotropic Glutamate 5 [D12.776.543.750.720.200.450.500.500]
Below are MeSH descriptors whose meaning is more specific than "Receptor, Metabotropic Glutamate 5".
This graph shows the total number of publications written about "Receptor, Metabotropic Glutamate 5" by people in this website by year, and whether "Receptor, Metabotropic Glutamate 5" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 3 | 3 |
| 2009 | 0 | 3 | 3 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 3 | 3 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 2 | 3 |
| 2015 | 2 | 0 | 2 |
| 2016 | 1 | 1 | 2 |
| 2017 | 1 | 1 | 2 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Receptor, Metabotropic Glutamate 5" by people in Profiles.
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Modulation of mGlu5 improves sensorimotor gating deficits in rats neonatally treated with quinpirole through changes in dopamine D2 signaling. Pharmacol Biochem Behav. 2021 12; 211:173292.
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Prefrontal Cortex KCa2 Channels Regulate mGlu5-Dependent Plasticity and Extinction of Alcohol-Seeking Behavior. J Neurosci. 2017 04 19; 37(16):4359-4369.
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Accumbens nNOS Interneurons Regulate Cocaine Relapse. J Neurosci. 2017 01 25; 37(4):742-756.
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Deficits in the extinction of ethanol-seeking behavior following chronic intermittent ethanol exposure are attenuated with positive allosteric modulation of mGlu5. Neuropharmacology. 2017 02; 113(Pt A):198-205.
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Altered glutamate release in the dorsal striatum of the MitoPark mouse model of Parkinson's disease. Brain Res. 2016 11 15; 1651:88-94.
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Perirhinal Cortex mGlu5 Receptor Activation Reduces Relapse to Methamphetamine Seeking by Restoring Novelty Salience. Neuropsychopharmacology. 2016 May; 41(6):1477-85.
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mGluR5 Positive and Negative Allosteric Modulators Differentially Affect Dendritic Spine Density and Morphology in the Prefrontal Cortex. CNS Neurol Disord Drug Targets. 2015; 14(4):476-85.
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Adolescent alcohol exposure reduces behavioral flexibility, promotes disinhibition, and increases resistance to extinction of ethanol self-administration in adulthood. Neuropsychopharmacology. 2014 Oct; 39(11):2570-83.
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Stress hormone exposure reduces mGluR5 expression in the nucleus accumbens: functional implications for interoceptive sensitivity to alcohol. Neuropsychopharmacology. 2014 Sep; 39(10):2376-86.
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Astrocytic dysfunction and addiction: consequences of impaired glutamate homeostasis. Neuroscientist. 2014 Dec; 20(6):610-22.