"Tissue Distribution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
| Descriptor ID |
D014018
|
| MeSH Number(s) |
G03.787.917 G07.690.725.949
|
| Concept/Terms |
Tissue Distribution- Tissue Distribution
- Distribution, Tissue
- Distributions, Tissue
- Tissue Distributions
|
Below are MeSH descriptors whose meaning is more general than "Tissue Distribution".
Below are MeSH descriptors whose meaning is more specific than "Tissue Distribution".
This graph shows the total number of publications written about "Tissue Distribution" by people in this website by year, and whether "Tissue Distribution" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 11 | 11 |
| 1996 | 0 | 10 | 10 |
| 1997 | 0 | 9 | 9 |
| 1998 | 0 | 4 | 4 |
| 1999 | 0 | 3 | 3 |
| 2000 | 0 | 6 | 6 |
| 2001 | 0 | 9 | 9 |
| 2002 | 0 | 4 | 4 |
| 2003 | 0 | 13 | 13 |
| 2004 | 0 | 7 | 7 |
| 2005 | 0 | 7 | 7 |
| 2006 | 0 | 10 | 10 |
| 2007 | 1 | 3 | 4 |
| 2008 | 0 | 3 | 3 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 6 | 6 |
| 2011 | 0 | 6 | 6 |
| 2012 | 0 | 3 | 3 |
| 2013 | 0 | 6 | 6 |
| 2014 | 0 | 5 | 5 |
| 2015 | 0 | 4 | 4 |
| 2016 | 0 | 2 | 2 |
| 2017 | 0 | 7 | 7 |
| 2018 | 0 | 4 | 4 |
| 2019 | 0 | 3 | 3 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 5 | 5 |
| 2022 | 0 | 4 | 4 |
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Below are the most recent publications written about "Tissue Distribution" by people in Profiles.
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CD44 receptor targeted nanoparticles augment immunity against tuberculosis in mice. J Control Release. 2022 09; 349:796-811.
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Imaging the Alternatively Spliced D Domain of Tenascin C in a Preclinical Model of Inflammatory Bowel Disease. Mol Imaging Biol. 2023 Apr; 25(2):314-323.
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Fibronectin extra domain A as a drug delivery targeting epitope for rheumatoid arthritis. Adv Rheumatol. 2022 05 27; 62(1):17.
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Comparative pharmacokinetics and tissue distribution of primaquine enantiomers in mice. Malar J. 2022 Feb 05; 21(1):33.
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Evaluation of Therapeutic Collagen-Based Biomaterials in the Infarcted Mouse Heart by Extracellular Matrix Targeted MALDI Imaging Mass Spectrometry. J Am Soc Mass Spectrom. 2021 Dec 01; 32(12):2746-2754.
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Preliminary studies on drug delivery of polymeric primaquine microparticles using the liver high uptake effect based on size of particles to improve malaria treatment. Mater Sci Eng C Mater Biol Appl. 2021 Sep; 128:112275.
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Externally triggered smart drug delivery system encapsulating idarubicin shows superior kinetics and enhances tumoral drug uptake and response. Theranostics. 2021; 11(12):5700-5712.
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Antiseptic-Mediated Colloid Labeling as a Potential Source of Abnormal Liver and Spleen Uptake with 99mTc-Dimercaptosuccinic Acid. J Nucl Med Technol. 2021 Sep; 49(3):290-291.
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Dual Encapsulated Dacarbazine and Zinc Phthalocyanine Polymeric Nanoparticle for Photodynamic Therapy of Melanoma. Pharm Res. 2021 Feb; 38(2):335-346.
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ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy. J Immunother Cancer. 2020 04; 8(1).