Kininogen, High-Molecular-Weight
"Kininogen, High-Molecular-Weight" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed)
| Descriptor ID |
D019679
|
| MeSH Number(s) |
D12.644.276.812.654.350 D12.776.124.125.635.480 D12.776.467.812.654.350 D12.776.811.420.350 D23.119.630.480 D23.469.050.375.425.350 D23.529.812.654.350
|
| Concept/Terms |
Kininogen, High-Molecular-Weight- Kininogen, High-Molecular-Weight
- Kininogen, High Molecular Weight
- High Molecular Weight Kininogens
- Kininogens, High Molecular Weight
- HMWK
- High-Molecular-Weight Kininogens
- Kininogens, High-Molecular-Weight
- High-Molecular-Weight Kininogen
- Fitzgerald Factor
- High Molecular Weight Kininogen
|
Below are MeSH descriptors whose meaning is more general than "Kininogen, High-Molecular-Weight".
Below are MeSH descriptors whose meaning is more specific than "Kininogen, High-Molecular-Weight".
This graph shows the total number of publications written about "Kininogen, High-Molecular-Weight" by people in this website by year, and whether "Kininogen, High-Molecular-Weight" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 3 | 0 | 3 |
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 1 | 2 |
| 2003 | 2 | 1 | 3 |
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 2 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 2 | 2 |
| 2016 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Kininogen, High-Molecular-Weight" by people in Profiles.
-
Protease activity in single-chain prekallikrein. Blood. 2020 02 20; 135(8):558-567.
-
Nomenclature of factor XI and the contact system. J Thromb Haemost. 2019 12; 17(12):2216-2219.
-
Cytokine and estrogen stimulation of endothelial cells augments activation of the prekallikrein-high molecular weight kininogen complex: Implications for hereditary angioedema. J Allergy Clin Immunol. 2017 Jul; 140(1):170-176.
-
Complement, Kinins, and Hereditary Angioedema: Mechanisms of Plasma Instability when C1 Inhibitor is Absent. Clin Rev Allergy Immunol. 2016 Oct; 51(2):207-15.
-
The bradykinin-forming cascade: a historical perspective. Chem Immunol Allergy. 2014; 100:205-13.
-
Pathogenic mechanisms of bradykinin mediated diseases: dysregulation of an innate inflammatory pathway. Adv Immunol. 2014; 121:41-89.
-
Factor XII-independent activation of the bradykinin-forming cascade: Implications for the pathogenesis of hereditary angioedema types I and II. J Allergy Clin Immunol. 2013 Aug; 132(2):470-5.
-
The plasma bradykinin-forming pathways and its interrelationships with complement. Mol Immunol. 2010 Aug; 47(13):2161-9.
-
The bradykinin-forming cascade and its role in hereditary angioedema. Ann Allergy Asthma Immunol. 2010 Mar; 104(3):193-204.
-
Factor XII-independent cleavage of high-molecular-weight kininogen by prekallikrein and inhibition by C1 inhibitor. J Allergy Clin Immunol. 2009 Jul; 124(1):143-9.