Complement C1 Inhibitor Protein
"Complement C1 Inhibitor Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An endogenous 105-kDa plasma glycoprotein produced primarily by the LIVER and MONOCYTES. It inhibits a broad spectrum of proteases, including the COMPLEMENT C1R and the COMPLEMENT C1S proteases of the CLASSICAL COMPLEMENT PATHWAY, and the MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. C1-INH-deficient individuals suffer from HEREDITARY ANGIOEDEMA TYPES I AND II.
| Descriptor ID |
D050718
|
| MeSH Number(s) |
D12.644.861.140.500 D12.776.124.486.274.920.250.500 D12.776.395.320 D12.776.872.140.500
|
| Concept/Terms |
Complement C1 Inhibitor Protein- Complement C1 Inhibitor Protein
- Serpin Family G Member 1
- C1 Esterase Inhibitor
- Esterase Inhibitor, C1
- C1-Inhibitor Protein
- C1 Inhibitor Protein
- Serpin G1
- G1, Serpin
- Plasma Protease C1 Inhibitor
- Complement C1-Inhibitor Protein
- SERPING1
- C1-INH Protein
- C1 INH Protein
|
Below are MeSH descriptors whose meaning is more general than "Complement C1 Inhibitor Protein".
Below are MeSH descriptors whose meaning is more specific than "Complement C1 Inhibitor Protein".
This graph shows the total number of publications written about "Complement C1 Inhibitor Protein" by people in this website by year, and whether "Complement C1 Inhibitor Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 3 | 1 | 4 |
| 2012 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 2 | 3 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 2 | 2 |
| 2017 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 2 | 0 | 2 |
| 2021 | 1 | 2 | 3 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement C1 Inhibitor Protein" by people in Profiles.
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The international WAO/EAACI guideline for the management of hereditary angioedema-The 2021 revision and update. Allergy. 2022 07; 77(7):1961-1990.
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Specific Targeting of Plasma Kallikrein for Treatment of Hereditary Angioedema: A Revolutionary Decade. J Allergy Clin Immunol Pract. 2022 03; 10(3):716-722.
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Analysis of cold activation of the contact system in hereditary angioedema with normal C1 inhibitor. Mol Immunol. 2021 08; 136:150-160.
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Blood Clotting and the Pathogenesis of Types I and II Hereditary Angioedema. Clin Rev Allergy Immunol. 2021 Jun; 60(3):348-356.
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Hereditary angioedema: Investigational therapies and future research. Allergy Asthma Proc. 2020 11 01; 41(Suppl 1):S51-S54.
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sgp120 and the contact system in hereditary angioedema: A diagnostic tool in HAE with normal C1 inhibitor. Mol Immunol. 2020 03; 119:27-34.
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C1 Inhibitor Activity and Angioedema Attacks in Patients with Hereditary Angioedema. J Allergy Clin Immunol Pract. 2020 03; 8(3):892-900.
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Pathogenesis of Hereditary Angioedema: The Role of the Bradykinin-Forming Cascade. Immunol Allergy Clin North Am. 2017 08; 37(3):513-525.
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Complement, Kinins, and Hereditary Angioedema: Mechanisms of Plasma Instability when C1 Inhibitor is Absent. Clin Rev Allergy Immunol. 2016 Oct; 51(2):207-15.
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Fibrinolysis and bradykinin formation: From in?vitro observations to human disease in "just" 45?years. J Allergy Clin Immunol. 2016 11; 138(5):1424-1425.