"Cell Cycle Checkpoints" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Regulatory signaling systems that control the progression through the CELL CYCLE. They ensure that the cell has completed, in the correct order and without mistakes, all the processes required to replicate the GENOME and CYTOPLASM, and divide them equally between two daughter cells. If cells sense they have not completed these processes or that the environment does not have the nutrients and growth hormones in place to proceed, then the cells are restrained (or "arrested") until the processes are completed and growth conditions are suitable.
Descriptor ID |
D059447
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MeSH Number(s) |
G04.144.109
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Concept/Terms |
Cell Cycle Checkpoints- Cell Cycle Checkpoints
- Cell Cycle Checkpoint
- Checkpoint, Cell Cycle
- Checkpoints, Cell Cycle
Cell Cycle Transition Points- Cell Cycle Transition Points
- Cell Cycle-Transition Points
- Cell Cycle-Transition Point
- Cycle-Transition Point, Cell
- Point, Cell Cycle-Transition
Cell Cycle Arrest- Cell Cycle Arrest
- Arrest, Cell Cycle
- Arrests, Cell Cycle
- Cell Cycle Arrests
Cell Cycle Control- Cell Cycle Control
- Cell Cycle Controls
- Control, Cell Cycle
- Controls, Cell Cycle
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Below are MeSH descriptors whose meaning is more general than "Cell Cycle Checkpoints".
Below are MeSH descriptors whose meaning is more specific than "Cell Cycle Checkpoints".
This graph shows the total number of publications written about "Cell Cycle Checkpoints" by people in this website by year, and whether "Cell Cycle Checkpoints" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2012 | 0 | 8 | 8 |
2013 | 2 | 3 | 5 |
2014 | 2 | 0 | 2 |
2015 | 1 | 1 | 2 |
2016 | 0 | 2 | 2 |
2018 | 0 | 2 | 2 |
2019 | 0 | 1 | 1 |
2020 | 0 | 1 | 1 |
2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cell Cycle Checkpoints" by people in Profiles.
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Changes in ionizing radiation dose rate affect cell cycle progression in adipose derived stem cells. PLoS One. 2021; 16(4):e0250160.
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Giants and monsters: Unexpected characters in the story of cancer recurrence. Adv Cancer Res. 2020; 148:201-232.
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Eukaryotic initiation factor 4E-binding protein as an oncogene in breast cancer. BMC Cancer. 2019 May 23; 19(1):491.
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Endoplasmic reticulum stress, autophagic and apoptotic cell death, and immune activation by a natural triterpenoid in human prostate cancer cells. J Cell Biochem. 2019 04; 120(4):6264-6276.
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Class I HDAC Inhibitors Display Different Antitumor Mechanism in Leukemia and Prostatic Cancer Cells Depending on Their p53 Status. J Med Chem. 2018 03 22; 61(6):2589-2603.
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PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma. PLoS Genet. 2016 Dec; 12(12):e1006518.
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3,39-Diindolylmethane Ameliorates Staphylococcal Enterotoxin B?Induced Acute Lung Injury through Alterations in the Expression of MicroRNA that Target Apoptosis and Cell-Cycle Arrest in Activated T Cells. J Pharmacol Exp Ther. 2016 Apr; 357(1):177-87.
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Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles. Nat Cell Biol. 2015 Aug; 17(8):1036-48.
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Design, synthesis, and antitumor evaluation of novel histone deacetylase inhibitors equipped with a phenylsulfonylfuroxan module as a nitric oxide donor. J Med Chem. 2015 May 28; 58(10):4325-38.
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Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in head and neck cancer through mitotic arrest followed by senescence. Mol Cancer Ther. 2015 Feb; 14(2):608-19.