Myelin proteins that are expressed as three isoforms: Nogo-A, Nogo-B, and Nogo-C. These share a C-terminal reticulon homology domain (RHD), consisting of two hydrophobic membrane domains flanking a 66 amino acid (Nogo-66) hydrophilic region. A long transmembrane region allows conformations that either span the entire membrane or fold into a hairpin conformation. Nogo inhibits NEURITE outgrowth and modulates wiring and the restriction of SYNAPTIC PLASTICITY in the adult central nervous system. It also regulates neurite fasciculation, branching, and extension in the developing nervous system.

Descriptor ID	D000070798
MeSH Number(s)	D12.776.543.620.738 D12.776.631.580.738
Concept/Terms	Nogo Proteins Nogo Proteins Nogo Protein Reticulon-4 Protein Reticulon 4 Protein Nogo-C Protein Nogo-C Protein Nogo C Protein Neurite Growth Inhibitor 35-350 Neurite Growth Inhibitor 35-350 Neurite Growth Inhibitor 35 350 NI-35-250 NI 35 250 Nogo-A Protein Nogo-A Protein Nogo A Protein NI-250 Protein NI 250 Protein NI-220 Protein NI 220 Protein NI-35 Protein NI-35 Protein NI 35 Protein Nogo-B Protein Nogo-B Protein Nogo B Protein Reticulon 4-B Protein Reticulon 4 B Protein Nogo-66 Protein Nogo-66 Protein Nogo 66 Protein

Below are MeSH descriptors whose meaning is more general than "Nogo Proteins".

Below are MeSH descriptors whose meaning is related to "Nogo Proteins".

Below are MeSH descriptors whose meaning is more specific than "Nogo Proteins".