Mismatch Repair Endonuclease PMS2
"Mismatch Repair Endonuclease PMS2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A MutL protein and component of the DNA MISMATCH REPAIR system. Its ENDONUCLEASE activity introduces SINGLE-STRAND DNA BREAKS which create entry points for EXO1 exonuclease to remove the strand containing the mismatch. It may also function in DNA DAMAGE signaling.
| Descriptor ID |
D000070976
|
| MeSH Number(s) |
D08.811.074.766.250 D08.811.277.040.025.215.250 D08.811.277.352.335.350.600 D12.776.260.540.250
|
| Concept/Terms |
Mismatch Repair Endonuclease PMS2- Mismatch Repair Endonuclease PMS2
- PMS1 Homolog 2, Mismatch Repair Protein
- PMS2 Protein
- Postmeiotic Segregation Increased-S. cerevisiae-2
- Postmeiotic Segregation Increased S. cerevisiae 2
- PMS-2 Protein
- PMS 2 Protein
|
Below are MeSH descriptors whose meaning is more general than "Mismatch Repair Endonuclease PMS2".
Below are MeSH descriptors whose meaning is more specific than "Mismatch Repair Endonuclease PMS2".
This graph shows the total number of publications written about "Mismatch Repair Endonuclease PMS2" by people in this website by year, and whether "Mismatch Repair Endonuclease PMS2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 2 | 2 |
| 2013 | 0 | 4 | 4 |
| 2015 | 0 | 3 | 3 |
| 2016 | 1 | 1 | 2 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 2 | 3 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mismatch Repair Endonuclease PMS2" by people in Profiles.
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Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report. Genet Med. 2021 04; 23(4):705-712.
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Type 2 diabetes mellitus, blood cholesterol, triglyceride and colorectal cancer risk in Lynch syndrome. Br J Cancer. 2019 11; 121(10):869-876.
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Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database. Genet Med. 2020 01; 22(1):15-25.
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Functional Repair Assay for the Diagnosis of Constitutional Mismatch Repair Deficiency From Non-Neoplastic Tissue. J Clin Oncol. 2019 02 20; 37(6):461-470.
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Cancer Risks for PMS2-Associated Lynch Syndrome. J Clin Oncol. 2018 10 10; 36(29):2961-2968.
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Determining the familial risk distribution of colorectal cancer: a data mining approach. Fam Cancer. 2016 Apr; 15(2):241-51.
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Germline mutations in PMS2 and MLH1 in individuals with solitary loss of PMS2 expression in colorectal carcinomas from the Colon Cancer Family Registry Cohort. BMJ Open. 2016 Feb 19; 6(2):e010293.
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Risk of colorectal cancer for people with a mutation in both a MUTYH and a DNA mismatch repair gene. Fam Cancer. 2015 Dec; 14(4):575-83.
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Mutation spectrum and risk of colorectal cancer in African American families with Lynch syndrome. Gastroenterology. 2015 Nov; 149(6):1446-53.
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Aspirin, Ibuprofen, and the Risk of Colorectal Cancer in Lynch Syndrome. J Natl Cancer Inst. 2015 Sep; 107(9).