"Lumican" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A small leucine-rich proteoglycan that contains 10 tandem leucine repeats and four N-linked sites within the leucine repeat region that may be substituted with KERATAN SULFATE. These properties and its horseshoe shape allow it to mediate interactions among COLLAGEN molecules within fibrils. It is expressed in most mesenchymal tissues as well as the CORNEA, where it functions to maintain transparency.
| Descriptor ID |
D000071234
|
| MeSH Number(s) |
D09.698.735.700.875 D12.776.395.650.875.750 D12.776.860.300.806.875
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Lumican".
Below are MeSH descriptors whose meaning is more specific than "Lumican".
This graph shows the total number of publications written about "Lumican" by people in this website by year, and whether "Lumican" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Lumican" by people in Profiles.
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Development of myotendinous-like junctions that anchor cardiac valves requires fibromodulin and lumican. Dev Dyn. 2016 10; 245(10):1029-42.
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Lumican deficiency results in cardiomyocyte hypertrophy with altered collagen assembly. J Mol Cell Cardiol. 2015 Jul; 84:70-80.
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A role for estrogen receptor-a and estrogen receptor-? in collagen biosynthesis in mouse skin. J Invest Dermatol. 2013 Jan; 133(1):120-7.
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Distinct effects of gonadectomy in male and female mice on collagen fibrillogenesis in the skin. J Dermatol Sci. 2007 Sep; 47(3):217-26.
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Immunohistochemical identification of proteoglycans in gelatinous membranes of cat and gerbil inner ear. Hear Res. 1991 Apr; 52(2):369-78.