Alpha-Ketoglutarate-Dependent Dioxygenase FTO
"Alpha-Ketoglutarate-Dependent Dioxygenase FTO" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS.
| Descriptor ID |
D000071516
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| MeSH Number(s) |
D08.811.074.062.968 D08.811.682.662.582.242 D08.811.682.690.416.139.992
|
| Concept/Terms |
Alpha-Ketoglutarate-Dependent Dioxygenase FTO- Alpha-Ketoglutarate-Dependent Dioxygenase FTO
- Alpha Ketoglutarate Dependent Dioxygenase FTO
- FTO, Alpha-Ketoglutarate-Dependent Dioxygenase
- Fat Mass and Obesity Associated (FTO) Protein
- Alpha-Ketoglutarate-Dependent Dioxygenase
- Alpha Ketoglutarate Dependent Dioxygenase
- Dioxygenase, Alpha-Ketoglutarate-Dependent
- Fat Mass and Obesity Associated Protein
- AlkB Homolog 9 Protein
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Below are MeSH descriptors whose meaning is more general than "Alpha-Ketoglutarate-Dependent Dioxygenase FTO".
Below are MeSH descriptors whose meaning is more specific than "Alpha-Ketoglutarate-Dependent Dioxygenase FTO".
This graph shows the total number of publications written about "Alpha-Ketoglutarate-Dependent Dioxygenase FTO" by people in this website by year, and whether "Alpha-Ketoglutarate-Dependent Dioxygenase FTO" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Alpha-Ketoglutarate-Dependent Dioxygenase FTO" by people in Profiles.
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The RNA demethylase FTO is required for maintenance of bone mass and functions to protect osteoblasts from genotoxic damage. Proc Natl Acad Sci U S A. 2019 09 03; 116(36):17980-17989.
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Reduced memory in fat mass and obesity-associated allele carriers among older adults with cardiovascular disease. Psychogeriatrics. 2013 Mar; 13(1):35-40.
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Influence of common variants in FTO and near INSIG2 and MC4R on growth curves for adiposity in African- and European-American youth. Eur J Epidemiol. 2011 Jun; 26(6):463-73.
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FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth. BMC Med Genet. 2010 Apr 09; 11:57.