"Cytochrome P-450 CYP2E1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include ETHANOL; INHALATION ANESTHETICS; BENZENE; ACETAMINOPHEN and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.
| Descriptor ID |
D019392
|
| MeSH Number(s) |
D08.244.453.491.375 D08.811.682.662.582.338 D08.811.682.690.708.170.450.375 D12.776.422.220.453.491.375
|
| Concept/Terms |
Cytochrome P-450 CYP2E1- Cytochrome P-450 CYP2E1
- Cytochrome P 450 CYP2E1
- Cytochrome P-450-J
- Cytochrome P 450 J
- 4-Nitrophenol-2-Hydroxylase
- 4 Nitrophenol 2 Hydroxylase
- Dimethylnitrosamine N-Demethylase
- Dimethylnitrosamine N Demethylase
- Cytochrome P450 2E1
- N-Nitrosodimethylamine Demethylase
- N Nitrosodimethylamine Demethylase
- CYP 2E1
- Cytochrome P-450 IIE1
- Cytochrome P 450 IIE1
- CYP IIE1
- CYPIIE1
- Cytochrome P-450 (ALC)
- CYP2E1
|
Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 CYP2E1".
Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 CYP2E1".
This graph shows the total number of publications written about "Cytochrome P-450 CYP2E1" by people in this website by year, and whether "Cytochrome P-450 CYP2E1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 2 | 2 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cytochrome P-450 CYP2E1" by people in Profiles.
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TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity. Free Radic Biol Med. 2017 01; 102:260-273.
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Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4 trafficking in lipid rafts via NADPH oxidase activation. Am J Physiol Gastrointest Liver Physiol. 2016 04 01; 310(7):G510-25.
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Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis. Biochim Biophys Acta. 2016 01; 1862(1):32-45.
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NKT cell modulates NAFLD potentiation of metabolic oxidative stress-induced mesangial cell activation and proximal tubular toxicity. Am J Physiol Renal Physiol. 2016 Jan 01; 310(1):F85-F101.
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M1 polarization bias and subsequent nonalcoholic steatohepatitis progression is attenuated by nitric oxide donor DETA NONOate via inhibition of CYP2E1-induced oxidative stress in obese mice. J Pharmacol Exp Ther. 2015 Jan; 352(1):77-89.
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Ethanol suppresses ureagenesis in rat hepatocytes: role of acetaldehyde. J Biol Chem. 2012 Mar 02; 287(10):7692-700.
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Carcinogen metabolism genes, red meat and poultry intake, and colorectal cancer risk. Int J Cancer. 2012 Apr 15; 130(8):1898-907.
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Association of CYP2E1 and NAT2 gene polymorphisms with chronic obstructive pulmonary disease. Clin Chim Acta. 2007 Jul; 382(1-2):37-42.
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A cytochrome P4502E1 genetic polymorphism and tobacco smoking in breast cancer. Mol Carcinog. 1996 Nov; 17(3):144-50.