"Soluble Guanylyl Cyclase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals.
| Descriptor ID |
D000071756
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| MeSH Number(s) |
D08.811.520.650.600.750 D12.644.360.350.500 D12.776.476.350.500
|
| Concept/Terms |
Soluble Guanylyl Cyclase- Soluble Guanylyl Cyclase
- Cyclase, Soluble Guanylyl
- Guanylyl Cyclase, Soluble
- Soluble Guanylate Cyclase
- Cyclase, Soluble Guanylate
- Guanylate Cyclase, Soluble
- Nitric Oxide-Sensitive Guanylyl Cyclase
- Nitric Oxide Sensitive Guanylyl Cyclase
- Receptor, Nitric Oxide
- Nitric Oxide Receptor
- Oxide Receptor, Nitric
- Nitric Oxide Receptors
- Oxide Receptors, Nitric
|
Below are MeSH descriptors whose meaning is more general than "Soluble Guanylyl Cyclase".
Below are MeSH descriptors whose meaning is more specific than "Soluble Guanylyl Cyclase".
This graph shows the total number of publications written about "Soluble Guanylyl Cyclase" by people in this website by year, and whether "Soluble Guanylyl Cyclase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 2 | 2 |
| 2015 | 0 | 2 | 2 |
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Below are the most recent publications written about "Soluble Guanylyl Cyclase" by people in Profiles.
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Reduced vascular responses to soluble guanylyl cyclase but increased sensitivity to sildenafil in female rats with type 2 diabetes. Am J Physiol Heart Circ Physiol. 2015 Jul 15; 309(2):H297-304.
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Riociguat: a novel new drug for treatment of pulmonary hypertension. Pharmacotherapy. 2015 May; 35(5):502-19.
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Generation, translocation, and action of nitric oxide in living systems. Chem Biol. 2011 Oct 28; 18(10):1211-20.
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Assessment of the effects of renal impairment on the pharmacokinetics of the soluble guanylate cyclase activator cinaciguat after a single intravenous dose. J Clin Pharmacol. 2012 Aug; 52(8):1240-7.