"Smoothened Receptor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A frizzled-like, G-protein-coupled receptor that associates with PATCHED RECEPTORS to transduce signals from HEDGEHOG PROTEINS and initiate hedgehog signaling to ZINC FINGER PROTEIN GLI1. It may normally inhibit signaling in the absence of SONIC HEDGEHOG PROTEIN binding to PATCHED RECEPTOR-1.
| Descriptor ID |
D000072086
|
| MeSH Number(s) |
D12.776.543.750.695.017.500 D12.776.543.750.850.500.500
|
| Concept/Terms |
Smoothened Receptor- Smoothened Receptor
- Receptor, Smoothened
- Smoothened Protein
- Smoothened Receptors
- Receptors, Smoothened
|
Below are MeSH descriptors whose meaning is more general than "Smoothened Receptor".
Below are MeSH descriptors whose meaning is more specific than "Smoothened Receptor".
This graph shows the total number of publications written about "Smoothened Receptor" by people in this website by year, and whether "Smoothened Receptor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Smoothened Receptor" by people in Profiles.
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A Druggable UHRF1/DNMT1/GLI Complex Regulates Sonic Hedgehog-Dependent Tumor Growth. Mol Cancer Res. 2022 Nov 03; 20(11):1598-1610.
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A CK1a Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma. Clin Cancer Res. 2019 02 15; 25(4):1379-1388.
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Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia. Genes Dev. 2016 09 01; 30(17):1943-55.
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Wnt/?-catenin and sonic hedgehog pathways interact in the regulation of the development of the dorsal mesenchymal protrusion. Dev Dyn. 2016 Feb; 245(2):103-13.
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The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers. J Biol Chem. 2014 Dec 19; 289(51):35494-502.
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Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy. Gut. 2014 Aug; 63(8):1333-44.
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Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction. Mol Cancer Ther. 2012 May; 11(5):1092-102.
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Hedgehog signaling induces arterial endothelial cell formation by repressing venous cell fate. Dev Biol. 2010 May 01; 341(1):196-204.