"Oleanolic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pentacyclic triterpene that occurs widely in many PLANTS as the free acid or the aglycone for many SAPONINS. It is biosynthesized from lupane. It can rearrange to the isomer, ursolic acid, or be oxidized to taraxasterol and amyrin.
| Descriptor ID |
D009828
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| MeSH Number(s) |
D02.455.849.919.530.733 D02.455.849.919.650.600
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Oleanolic Acid".
Below are MeSH descriptors whose meaning is more specific than "Oleanolic Acid".
This graph shows the total number of publications written about "Oleanolic Acid" by people in this website by year, and whether "Oleanolic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 2 | 0 | 2 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Oleanolic Acid" by people in Profiles.
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CDDO and Its Role in Chronic Diseases. Adv Exp Med Biol. 2016; 929:291-314.
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Targeting Nrf2 by dihydro-CDDO-trifluoroethyl amide enhances autophagic clearance and viability of ?-cells in a setting of oxidative stress. FEBS Lett. 2014 Jun 05; 588(12):2115-24.
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Dihydro-CDDO-trifluoroethyl amide suppresses inflammatory responses in macrophages via activation of Nrf2. Biochem Biophys Res Commun. 2014 Feb 21; 444(4):555-61.
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Triterpenoid dihydro-CDDO-trifluoroethyl amide protects against maladaptive cardiac remodeling and dysfunction in mice: a critical role of Nrf2. PLoS One. 2012; 7(9):e44899.
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Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes. PLoS One. 2009 Dec 21; 4(12):e8391.
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Synthetic triterpenoids have cytotoxicity in pediatric acute lymphoblastic leukemia cell lines but cytotoxicity is independent of induced ceramide increase in MOLT-4 cells. Leukemia. 2008 Jun; 22(6):1258-62.
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Structure elucidation of three triterpene glycosides from the trunk of Argania spinosa. J Nat Prod. 1996 Feb; 59(2):193-5.
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Triterpenoid glycosides from the bark of Mimosa tenuiflora. Phytochemistry. 1991; 30(7):2357-60.