"Gene Products, rev" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Trans-acting nuclear proteins whose functional expression are required for retroviral replication. Specifically, the rev gene products are required for processing and translation of the gag and env mRNAs, and thus rev regulates the expression of the viral structural proteins. rev can also regulate viral regulatory proteins. A cis-acting antirepression sequence (CAR) in env, also known as the rev-responsive element (RRE), is responsive to the rev gene product. rev is short for regulator of virion.
| Descriptor ID |
D015694
|
| MeSH Number(s) |
D12.776.157.725.076 D12.776.664.962.186 D12.776.964.925.984.385
|
| Concept/Terms |
Gene Products, rev- Gene Products, rev
- rev Gene Products
- rev Protein
- Gene Product, rev
- rev Gene Product
|
Below are MeSH descriptors whose meaning is more general than "Gene Products, rev".
Below are MeSH descriptors whose meaning is more specific than "Gene Products, rev".
This graph shows the total number of publications written about "Gene Products, rev" by people in this website by year, and whether "Gene Products, rev" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1996 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 1999 | 2 | 1 | 3 |
| 2003 | 0 | 1 | 1 |
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Below are the most recent publications written about "Gene Products, rev" by people in Profiles.
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Improved protection of rhesus macaques against intrarectal simian immunodeficiency virus SIV(mac251) challenge by a replication-competent Ad5hr-SIVenv/rev and Ad5hr-SIVgag recombinant priming/gp120 boosting regimen. J Virol. 2003 Aug; 77(15):8354-65.
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HIV-1 Rev promotes the nuclear export of unspliced and singly spliced RNAs in a mammalian cell-free export system. J Biomed Sci. 1999 May-Jun; 6(3):194-205.
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Effect of rev on the cytoplasmic localization of intron-containing human immunodeficiency virus type 1 RNA. Virology. 1999 Mar 15; 255(2):237-49.
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Activation of a cryptic splice donor in human immunodeficiency virus type-1. J Biomed Sci. 1999 Jan; 6(1):45-52.
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Effect of Rev on the intranuclear localization of HIV-1 unspliced RNA. Virology. 1998 Sep 30; 249(2):286-96.
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Differential effects of intronic and exonic locations of the human immunodeficiency virus type 1 Rev-responsive element. Virology. 1996 May 15; 219(2):423-31.
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Human immunodeficiency virus type 1 Rev is required in vivo for binding of poly(A)-binding protein to Rev-dependent RNAs. J Virol. 1994 Sep; 68(9):5433-8.