"Insulysin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme the catalyzes the degradation of insulin, glucagon and other polypeptides. It is inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not phosphoramidon. (Eur J Biochem 1994;223:1-5) EC 3.4.24.56.
| Descriptor ID |
D007339
|
| MeSH Number(s) |
D08.811.277.656.300.480.300 D08.811.277.656.675.374.300
|
| Concept/Terms |
Insulysin- Insulysin
- Insulin-Degrading Enzyme
- Enzyme, Insulin-Degrading
- Insulin Degrading Enzyme
- Insulin Protease
- Protease, Insulin
- Insulin Proteinase
- Proteinase, Insulin
- Insulinase
|
Below are MeSH descriptors whose meaning is more general than "Insulysin".
Below are MeSH descriptors whose meaning is more specific than "Insulysin".
This graph shows the total number of publications written about "Insulysin" by people in this website by year, and whether "Insulysin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Insulysin" by people in Profiles.
-
Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease. PLoS One. 2010 Jan 19; 5(1):e8764.
-
Insulysin cleaves the APP cytoplasmic fragment at multiple sites. Neurochem Res. 2007 Dec; 32(12):2225-34.
-
Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):6221-6.