"Botulinum Toxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
Descriptor ID |
D001905
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MeSH Number(s) |
D08.811.277.656.300.480.153 D08.811.277.656.675.374.153 D12.776.097.156 D23.946.123.179
|
Concept/Terms |
Botulinum Toxins- Botulinum Toxins
- Toxins, Botulinum
- Botulinum Toxin
- Toxin, Botulinum
- Clostridium botulinum Toxins
- Toxins, Clostridium botulinum
- Botulin
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Below are MeSH descriptors whose meaning is more general than "Botulinum Toxins".
Below are MeSH descriptors whose meaning is more specific than "Botulinum Toxins".
This graph shows the total number of publications written about "Botulinum Toxins" by people in this website by year, and whether "Botulinum Toxins" was a major or minor topic of these publications.
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click here.
Year | Major Topic | Minor Topic | Total |
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1996 | 1 | 0 | 1 |
1997 | 1 | 0 | 1 |
1999 | 1 | 0 | 1 |
2003 | 0 | 1 | 1 |
2006 | 0 | 1 | 1 |
2011 | 0 | 1 | 1 |
2014 | 1 | 0 | 1 |
2015 | 1 | 1 | 2 |
2018 | 0 | 2 | 2 |
2020 | 2 | 0 | 2 |
2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Botulinum Toxins" by people in Profiles.
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Treatment outcomes of overactive bladder with combined therapies of botulinum toxin injections and oral agents. Int Urogynecol J. 2021 Oct; 32(10):2803-2806.
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Quality Assessment of Online Patient Information for Cosmetic Botulinum Toxin. Aesthet Surg J. 2020 10 24; 40(11):NP636-NP642.
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The Role of Radiation Therapy and Botulinum Toxin Injections in the Management of Sialorrhea in Patients With Amyotrophic Lateral Sclerosis: A Systematic Review. J Clin Neuromuscul Dis. 2020 Jun; 21(4):205-221.
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The 2018 ISDE achalasia guidelines. Dis Esophagus. 2018 Sep 01; 31(9).
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Distal Esophageal Spasm: A Review. Am J Med. 2018 09; 131(9):1034-1040.
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Collum-caput (COL-CAP) concept for conceptual anterocollis, anterocaput, and forward sagittal shift. J Neurol Sci. 2015 Aug 15; 355(1-2):37-43.
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Multiple good options are available for achalasia management. J Clin Gastroenterol. 2015 Mar; 49(3):194-8.
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Pyridostigmine for reversal of severe sequelae from botulinum toxin injection. J Voice. 2014 Nov; 28(6):830-4.
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Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G317-25.
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Review article: oesophageal spasm - diagnosis and management. Aliment Pharmacol Ther. 2006 May 15; 23(10):1393-402.