"Prothrombin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.
| Descriptor ID |
D011516
|
| MeSH Number(s) |
D08.622.709 D12.776.124.125.800 D23.119.945
|
| Concept/Terms |
Prothrombin- Prothrombin
- Factor II
- Blood Coagulation Factor II
- Differentiation Reversal Factor
- Factor, Differentiation Reversal
- Coagulation Factor II
- Factor II, Coagulation
- II, Coagulation Factor
|
Below are MeSH descriptors whose meaning is more general than "Prothrombin".
Below are MeSH descriptors whose meaning is more specific than "Prothrombin".
This graph shows the total number of publications written about "Prothrombin" by people in this website by year, and whether "Prothrombin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 1999 | 0 | 2 | 2 |
| 2005 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Prothrombin" by people in Profiles.
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Thrombin generation and cell-dependent hypercoagulability in sickle cell disease. J Thromb Haemost. 2016 10; 14(10):1941-1952.
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Thrombophilic risk of individuals with rare compound factor V Leiden and prothrombin G20210A polymorphisms: an international case series of 100 individuals. Eur J Haematol. 2016 Oct; 97(4):353-60.
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Inherited thrombophilia in childhood arterial stroke: data from Lebanon. Pediatr Neurol. 2011 Sep; 45(3):155-8.
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Effect of apixaban, an oral and direct factor Xa inhibitor, on coagulation activity biomarkers following acute coronary syndrome. Thromb Haemost. 2010 Nov; 104(5):976-83.
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Technical standards and guidelines: venous thromboembolism (Factor V Leiden and prothrombin 20210G >A testing): a disease-specific supplement to the standards and guidelines for clinical genetics laboratories. Genet Med. 2005 Jul-Aug; 7(6):444-53.
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Hemostatic responses to maximal exercise in oral contraceptive users. Am J Obstet Gynecol. 1999 Oct; 181(4):958-63.
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Effectiveness of heparin in preventing thrombin generation and thrombin activity in patients undergoing coronary intervention. Am Heart J. 1999 Feb; 137(2):250-7.
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Standardization of prothrombin fragment 1.2 measurement: effects of preanalytical variables and calibrator selection. Arch Pathol Lab Med. 1998 Jan; 122(1):31-6.
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Evaluation of preanalytical variables associated with measurement of prothrombin fragment 1.2. Clin Chem. 1994 Oct; 40(10):1962-9.
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Characterization of prothrombin activation during cardiac surgery by hemostatic molecular markers. Anesthesiology. 1994 Mar; 80(3):520-6.