"Leukotriene A4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
(2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate precursor 5-HPETE via the stereospecific removal of a proton at C-10 and dehydration. Its biological actions are determined primarily by its metabolites, i.e., LEUKOTRIENE B4 and cysteinyl-leukotrienes. Alternatively, leukotriene A4 is converted into LEUKOTRIENE C4 by glutathione-S-transferase or into 5,6-di-HETE by the epoxide-hydrolase. (From Dictionary of Prostaglandins and Related Compounds, 1990)
| Descriptor ID |
D017572
|
| MeSH Number(s) |
D10.251.355.255.100.450.405 D10.251.355.310.166.887.405 D23.469.050.175.450.400
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Leukotriene A4".
Below are MeSH descriptors whose meaning is more specific than "Leukotriene A4".
This graph shows the total number of publications written about "Leukotriene A4" by people in this website by year, and whether "Leukotriene A4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "Leukotriene A4" by people in Profiles.
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Prevention of upper aerodigestive tract cancer in zinc-deficient rodents: inefficacy of genetic or pharmacological disruption of COX-2. Int J Cancer. 2008 Mar 01; 122(5):978-89.
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Leukotriene A4 signaling, inflammation, and cancer. J Natl Cancer Inst. 2003 Jul 16; 95(14):1028-9.