"SRS-A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of LEUKOTRIENES; (LTC4; LTD4; and LTE4) that is the major mediator of BRONCHOCONSTRICTION; HYPERSENSITIVITY; and other allergic reactions. Earlier studies described a "slow-reacting substance of ANAPHYLAXIS" released from lung by cobra venom or after anaphylactic shock. The relationship between SRS-A leukotrienes was established by UV which showed the presence of the conjugated triene. (From Merck Index, 11th ed)
| Descriptor ID |
D013189
|
| MeSH Number(s) |
D10.251.355.255.100.450.855 D10.251.355.310.166.887.855 D23.469.050.175.450.725
|
| Concept/Terms |
SRS-A- SRS-A
- Slow Reacting Substance of Anaphylaxis
|
Below are MeSH descriptors whose meaning is more general than "SRS-A".
Below are MeSH descriptors whose meaning is more specific than "SRS-A".
This graph shows the total number of publications written about "SRS-A" by people in this website by year, and whether "SRS-A" was a major or minor topic of these publications.
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Below are the most recent publications written about "SRS-A" by people in Profiles.
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Characterization of distinct receptors for the peptidyl leukotrienes LTC4 and LTD4/LTE4 coupled to the same signaling pathway in isolated gastric muscle cells. J Pharmacol Exp Ther. 1993 Aug; 266(2):857-63.
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Effect of the LTD4 receptor antagonist LY203647 on endotoxic shock sequelae in the rat. Eur J Pharmacol. 1991 Jun 25; 199(2):221-5.
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Effect of a LTD4 receptor antagonist in porcine septic shock. Eicosanoids. 1991; 4(3):169-75.
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Resistance of essential fatty acid-deficient rats to endotoxin-induced increases in vascular permeability. Circ Shock. 1990 Jun; 31(2):159-70.
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Hemodynamic effects of leukotriene (LT) D4 and a LTD4 receptor antagonist in the pig. Eicosanoids. 1990; 3(4):219-24.
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Essential fatty acid-deficient rats are resistant to oleic acid-induced pulmonary injury. J Appl Physiol (1985). 1989 Aug; 67(2):811-6.
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Oleic acid-induced pulmonary injury in rats: potential role of sulfidopeptide leukotrienes. Circ Shock. 1988 Sep; 26(1):59-70.
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Oleic acid induces pulmonary injury independent of eicosanoids in the isolated, perfused rabbit lung. Circ Shock. 1987; 22(3):221-30.
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Beneficial effects of a leukotriene antagonist on endotoxin-induced acute hemodynamic alterations. Circ Shock. 1987; 22(1):55-63.
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[The role of thromboxane A2, prostaglandin I2 and leukotrienes in cerebral ischemia]. Changgeng Yi Xue Za Zhi. 1986 Jun 20; 9(2):139-45.