"Dithiothreitol" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols.
| Descriptor ID |
D004229
|
| MeSH Number(s) |
D02.033.800.196 D02.886.740.224 D09.853.196
|
| Concept/Terms |
Dithiothreitol- Dithiothreitol
- Cleland's Reagent
- Clelands Reagent
- Reagent, Cleland's
- Cleland Reagent
- Reagent, Cleland
|
Below are MeSH descriptors whose meaning is more general than "Dithiothreitol".
Below are MeSH descriptors whose meaning is more specific than "Dithiothreitol".
This graph shows the total number of publications written about "Dithiothreitol" by people in this website by year, and whether "Dithiothreitol" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1997 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2008 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Dithiothreitol" by people in Profiles.
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Cautionary Tale of Using Tris(alkyl)phosphine Reducing Agents with NAD+-Dependent Enzymes. Biochemistry. 2020 09 15; 59(36):3285-3289.
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Secretagogin Is a Redox-Responsive Ca2+ Sensor. Biochemistry. 2017 Jan 17; 56(2):411-420.
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Thiol antioxidants regulate angiotensin II AT1 and arginine vasopressin V1 receptor functions differently in vascular smooth muscle cells. Am J Hypertens. 2009 Feb; 22(2):221-7.
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Simulation of large-scale production of a soluble recombinant protein expressed in Escherichia coli using an intein-mediated purification system. Appl Biochem Biotechnol. 2005 Aug; 126(2):93-118.
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Primaquine-induced hemolytic anemia: role of membrane lipid peroxidation and cytoskeletal protein alterations in the hemotoxicity of 5-hydroxyprimaquine. J Pharmacol Exp Ther. 2005 Aug; 314(2):838-45.
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Purification and characterization of Helicobacter pylori arginase, RocF: unique features among the arginase superfamily. Eur J Biochem. 2004 May; 271(10):1952-62.
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Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione. J Biol Chem. 1997 Jun 27; 272(26):16281-7.
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The effects of thiol reduction and oxidation on the inhibition of NMDA-stimulated neurotransmitter release by ethanol. Neuropharmacology. 1994 May; 33(5):635-40.
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The appearance, distribution, and longevity of receptor-[125I]T3 complexes within the nuclei of isolated rat hepatocytes. Thyroid. 1994; 4(3):305-12.
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Dapsone-induced hemolytic anemia: effect of N-hydroxy dapsone on the sulfhydryl status and membrane proteins of rat erythrocytes. Toxicol Appl Pharmacol. 1992 Dec; 117(2):208-17.