"Sulindac" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.
| Descriptor ID |
D013467
|
| MeSH Number(s) |
D02.455.426.559.847.486.875 D04.615.486.875
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Sulindac".
Below are MeSH descriptors whose meaning is more specific than "Sulindac".
This graph shows the total number of publications written about "Sulindac" by people in this website by year, and whether "Sulindac" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2004 | 0 | 2 | 2 |
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Below are the most recent publications written about "Sulindac" by people in Profiles.
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Induction of transcription by p21Waf1/Cip1/Sdi1: role of NFkappaB and effect of non-steroidal anti-inflammatory drugs. Cell Cycle. 2004 Jul; 3(7):931-40.
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COX-2 inhibition and colorectal cancer. Semin Oncol. 2004 Apr; 31(2 Suppl 7):12-21.
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Primary chemoprevention of familial adenomatous polyposis with sulindac. N Engl J Med. 2002 Apr 04; 346(14):1054-9.
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Sulindac does not preserve renal prostacyclin synthesis during endotoxemia. Prostaglandins. 1985 Jun; 29(6):1031-7.