Platelet Glycoprotein GPIb-IX Complex
"Platelet Glycoprotein GPIb-IX Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome.
| Descriptor ID |
D019038
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| MeSH Number(s) |
D12.776.395.550.625.460 D12.776.543.550.625.460 D12.776.543.750.705.675.568
|
| Concept/Terms |
CD42c Antigens- CD42c Antigens
- Glycoprotein Ib beta
- CD42c Antigen
- Antigen, CD42c
- Antigens, CD42c
CD42b Antigens- CD42b Antigens
- Antigens, CD42b
- Glycoprotein Ib alpha
- CD42b Antigen
- Antigen, CD42b
CD42d Antigen- CD42d Antigen
- Antigen, CD42d
- CD42d Antigens
- Antigens, CD42d
|
Below are MeSH descriptors whose meaning is more general than "Platelet Glycoprotein GPIb-IX Complex".
Below are MeSH descriptors whose meaning is more specific than "Platelet Glycoprotein GPIb-IX Complex".
This graph shows the total number of publications written about "Platelet Glycoprotein GPIb-IX Complex" by people in this website by year, and whether "Platelet Glycoprotein GPIb-IX Complex" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Platelet Glycoprotein GPIb-IX Complex" by people in Profiles.
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Structural basis of regulation of von Willebrand factor binding to glycoprotein Ib. J Biol Chem. 2014 Feb 28; 289(9):5565-79.
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Delineating the roles of the GPIIb/IIIa and GP-Ib-IX-V platelet receptors in mediating platelet adhesion to adsorbed fibrinogen and albumin. Biomaterials. 2011 Aug; 32(23):5365-70.
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Endothelial microparticle levels are similar in acute ischemic stroke and stroke mimics due to activation and not apoptosis/necrosis. Acad Emerg Med. 2007 Aug; 14(8):685-90.
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Ets-dependent regulation of target gene expression during megakaryopoiesis. J Biol Chem. 2004 Dec 10; 279(50):52183-90.
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The role of the porcine von Willebrand factor: baboon platelet interactions in pulmonary xenotransplantation. Transplantation. 2002 Dec 15; 74(11):1596-603.
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Platelet glycoprotein Ib: a zinc-dependent binding protein for the heavy chain of high-molecular-weight kininogen. Mol Med. 1999 Aug; 5(8):555-63.