"Founder Effect" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phenomenon that is observed when a small subgroup of a larger POPULATION establishes itself as a separate and isolated entity. The subgroup's GENE POOL carries only a fraction of the genetic diversity of the parental population resulting in an increased frequency of certain diseases in the subgroup, especially those diseases known to be autosomal recessive.
| Descriptor ID |
D018703
|
| MeSH Number(s) |
G05.285
|
| Concept/Terms |
Founder Effect- Founder Effect
- Effect, Founder
- Effects, Founder
- Founder Effects
|
Below are MeSH descriptors whose meaning is more general than "Founder Effect".
Below are MeSH descriptors whose meaning is more specific than "Founder Effect".
This graph shows the total number of publications written about "Founder Effect" by people in this website by year, and whether "Founder Effect" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Founder Effect" by people in Profiles.
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A high prevalence of biallelic RPE65 mutations in Costa Rican children with Leber congenital amaurosis and early-onset retinal dystrophy. Ophthalmic Genet. 2019 04; 40(2):110-117.
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Laboratory selection quickly erases historical differentiation. PLoS One. 2014; 9(5):e96227.
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Fast evolutionary genetic differentiation during experimental colonizations. J Genet. 2013; 92(2):183-94.
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How repeatable is adaptive evolution? The role of geographical origin and founder effects in laboratory adaptation. Evolution. 2008 Aug; 62(8):1817-29.
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Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia. Cancer Cell. 2005 Nov; 8(5):421-32.