Procollagen-Proline Dioxygenase
"Procollagen-Proline Dioxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl containing peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES.
| Descriptor ID |
D011393
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| MeSH Number(s) |
D08.811.682.690.416.617.750 D08.811.682.690.708.694.750
|
| Concept/Terms |
Procollagen-Proline Dioxygenase- Procollagen-Proline Dioxygenase
- Dioxygenase, Procollagen-Proline
- Procollagen Proline Dioxygenase
- Protocollagen Prolyl Hydroxylase
- Hydroxylase, Protocollagen Prolyl
- Prolyl Hydroxylase, Protocollagen
- Procollagen Prolyl 4-Hydroxylase
- 4-Hydroxylase, Procollagen Prolyl
- Procollagen Prolyl 4 Hydroxylase
- Prolyl 4-Hydroxylase, Procollagen
|
Below are MeSH descriptors whose meaning is more general than "Procollagen-Proline Dioxygenase".
Below are MeSH descriptors whose meaning is more specific than "Procollagen-Proline Dioxygenase".
This graph shows the total number of publications written about "Procollagen-Proline Dioxygenase" by people in this website by year, and whether "Procollagen-Proline Dioxygenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2008 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Procollagen-Proline Dioxygenase" by people in Profiles.
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Tuning isoform selectivity and bortezomib sensitivity with a new class of alkenyl indene PDI inhibitor. Eur J Med Chem. 2020 Jan 15; 186:111906.
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Hsp90 Co-chaperone p23 contributes to dopaminergic mitochondrial stress via stabilization of PHD2: Implications for Parkinson's disease. Neurotoxicology. 2018 03; 65:166-173.
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Hypoxia up-regulates expression of hemoglobin in alveolar epithelial cells. Am J Respir Cell Mol Biol. 2011 Apr; 44(4):439-47.
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Activation of the oxygen-sensing signal cascade prevents mitochondrial injury after mouse liver ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol. 2008 Oct; 295(4):G823-32.
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O(2)-sensing signal cascade: clamping of O(2) respiration, reduced ATP utilization, and inducible fumarate respiration. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C29-37.
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The prolyl hydroxylase oxygen-sensing pathway is cytoprotective and allows maintenance of mitochondrial membrane potential during metabolic inhibition. Am J Physiol Cell Physiol. 2007 Feb; 292(2):C719-28.
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Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin. Am J Pathol. 2003 Aug; 163(2):571-81.