"Picrotoxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.
| Descriptor ID |
D010852
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| MeSH Number(s) |
D02.455.426.392.368.367.800 D02.540.552
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Picrotoxin".
Below are MeSH descriptors whose meaning is more specific than "Picrotoxin".
This graph shows the total number of publications written about "Picrotoxin" by people in this website by year, and whether "Picrotoxin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Picrotoxin" by people in Profiles.
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The ethanol inhibition of basolateral amygdala neuron spiking is mediated by a ?-aminobutyric acid type A-mediated tonic current. Alcohol Clin Exp Res. 2022 Sep; 46(9):1665-1676.
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Ethanol reduces neuronal excitability of lateral orbitofrontal cortex neurons via a glycine receptor dependent mechanism. Neuropsychopharmacology. 2013 Jun; 38(7):1176-88.
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Pharmacological characterization of glycine-gated chloride currents recorded in rat hippocampal slices. J Neurophysiol. 2002 Mar; 87(3):1515-25.
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Functionally distinct groups of interneurons identified during rhythmic carbachol oscillations in hippocampus in vitro. J Neurosci. 1998 Aug 01; 18(15):5640-51.
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Low-dose effect of ethanol on locomotor activity induced by activation of the mesolimbic system. Alcohol Clin Exp Res. 1995 Jun; 19(3):768-76.
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Dopamine and endogenous opioid regulation of picrotoxin-induced locomotion in the ventral pallidum after dopamine depletion in the nucleus accumbens. Psychopharmacology (Berl). 1992; 108(1-2):141-6.
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Dopaminergic involvement in locomotion elicited from the ventral pallidum/substantia innominata. Brain Res. 1991 Feb 22; 542(1):123-31.
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GABAergic and enkephalinergic regulation of locomotion in the ventral pallidum: involvement of the mesolimbic dopamine system. Adv Exp Med Biol. 1991; 295:315-26.
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Valproate potentiates and picrotoxin antagonizes the anxiolytic action of ethanol in a nonshock conflict task. Neuropharmacology. 1990 Sep; 29(9):837-43.
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Enkephalinergic and GABAergic modulation of motor activity in the ventral pallidum. J Pharmacol Exp Ther. 1990 Mar; 252(3):1370-7.