6-Cyano-7-nitroquinoxaline-2,3-dione
"6-Cyano-7-nitroquinoxaline-2,3-dione" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potent excitatory amino acid antagonist with a preference for non-NMDA iontropic receptors. It is used primarily as a research tool.
| Descriptor ID |
D018750
|
| MeSH Number(s) |
D03.633.100.857.160
|
| Concept/Terms |
6-Cyano-7-nitroquinoxaline-2,3-dione- 6-Cyano-7-nitroquinoxaline-2,3-dione
- 6 Cyano 7 nitroquinoxaline 2,3 dione
- 1,4-dihydro-2,3-dihydroxy-7-nitro-6-quinoxalinecarbonitrile
- CNQX
- 6-Cyano-2,3-dihydroxy-7-nitroquinoxaline
- 6 Cyano 2,3 dihydroxy 7 nitroquinoxaline
|
Below are MeSH descriptors whose meaning is more general than "6-Cyano-7-nitroquinoxaline-2,3-dione".
Below are MeSH descriptors whose meaning is more specific than "6-Cyano-7-nitroquinoxaline-2,3-dione".
This graph shows the total number of publications written about "6-Cyano-7-nitroquinoxaline-2,3-dione" by people in this website by year, and whether "6-Cyano-7-nitroquinoxaline-2,3-dione" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2013 | 0 | 4 | 4 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "6-Cyano-7-nitroquinoxaline-2,3-dione" by people in Profiles.
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The neurotoxin domoate causes long-lasting inhibition of the kainate receptor GluK5 subunit. Neuropharmacology. 2014 Oct; 85:9-17.
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Agonist binding to the GluK5 subunit is sufficient for functional surface expression of heteromeric GluK2/GluK5 kainate receptors. Cell Mol Neurobiol. 2013 Nov; 33(8):1099-108.
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Neural origin of evoked potentials during thalamic deep brain stimulation. J Neurophysiol. 2013 Aug; 110(4):826-43.
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Adenosine A1 and dopamine d1 receptor regulation of AMPA receptor phosphorylation and cocaine-seeking behavior. Neuropsychopharmacology. 2013 Sep; 38(10):1974-83.
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Cross-sensitization between cocaine and acute restraint stress is associated with sensitized dopamine but not glutamate release in the nucleus accumbens. Eur J Neurosci. 2013 Mar; 37(6):982-95.
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Glutamate release in the nucleus accumbens core is necessary for heroin seeking. J Neurosci. 2008 Mar 19; 28(12):3170-7.
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LTP in the lateral amygdala during cocaine withdrawal. Eur J Neurosci. 2006 Jan; 23(1):239-50.
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Dopamine, but not glutamate, receptor blockade in the basolateral amygdala attenuates conditioned reward in a rat model of relapse to cocaine-seeking behavior. Psychopharmacology (Berl). 2001 Mar; 154(3):301-10.
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Context-specific enhancement of glutamate transmission by cocaine. Neuropsychopharmacology. 2000 Sep; 23(3):335-44.
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A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior. Neuroscience. 1999; 93(4):1359-67.