"Tyrphostins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of synthetic protein tyrosine kinase inhibitors. They selectively inhibit receptor autophosphorylation and are used to study receptor function.
| Descriptor ID |
D020032
|
| MeSH Number(s) |
D02.455.426.559.389.150.795 D02.626.886 D03.633.100.857.885
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Tyrphostins".
Below are MeSH descriptors whose meaning is more specific than "Tyrphostins".
This graph shows the total number of publications written about "Tyrphostins" by people in this website by year, and whether "Tyrphostins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 2 | 3 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tyrphostins" by people in Profiles.
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Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. Chem Biol. 2008 Sep 22; 15(9):969-78.
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Human bone marrow activates the Akt pathway in metastatic prostate cells through transactivation of the alpha-platelet-derived growth factor receptor. Cancer Res. 2007 Jan 15; 67(2):555-62.
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beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts. J Biol Chem. 2005 Sep 16; 280(37):32157-67.
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Mechanisms of vascular angiotensin II surface receptor regulation by epidermal growth factor. J Cell Physiol. 2004 Sep; 200(3):451-7.
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Ectodomain shedding-dependent transactivation of epidermal growth factor receptors in response to insulin-like growth factor type I. Mol Endocrinol. 2004 Nov; 18(11):2727-39.
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Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts. Mol Endocrinol. 2003 Aug; 17(8):1607-21.
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A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations. Blood. 2001 Aug 01; 98(3):885-7.
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Receptor tyrosine kinase inhibition suppresses growth of pediatric renal tumor cells in vitro. J Pediatr Surg. 2000 Jun; 35(6):884-90.
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Mitogenic signaling in androgen sensitive and insensitive prostate cancer cell lines. J Urol. 2000 Mar; 163(3):1027-32.
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Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1489-94.