"Phospholipase C gamma" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phosphoinositide phospholipase C subtype that is primarily regulated by PROTEIN-TYROSINE KINASES. It is structurally related to PHOSPHOLIPASE C DELTA with the addition of SRC HOMOLOGY DOMAINS and pleckstrin homology domains located between two halves of the CATALYTIC DOMAIN.
Descriptor ID |
D051966
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MeSH Number(s) |
D08.811.277.352.640.700.700.562.750 D12.644.360.571.750 D12.776.476.556.750
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Phospholipase C gamma".
Below are MeSH descriptors whose meaning is more specific than "Phospholipase C gamma".
This graph shows the total number of publications written about "Phospholipase C gamma" by people in this website by year, and whether "Phospholipase C gamma" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1998 | 0 | 2 | 2 |
2000 | 0 | 1 | 1 |
2002 | 0 | 3 | 3 |
2014 | 0 | 1 | 1 |
2015 | 0 | 1 | 1 |
2017 | 1 | 0 | 1 |
2019 | 0 | 1 | 1 |
2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phospholipase C gamma" by people in Profiles.
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TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth. Nat Commun. 2021 09 09; 12(1):5337.
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ErbB4 promotes malignant peripheral nerve sheath tumor pathogenesis via Ras-independent mechanisms. Cell Commun Signal. 2019 07 10; 17(1):74.
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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet. 2017 09; 49(9):1373-1384.
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Etiology of Ibrutinib Therapy Discontinuation and Outcomes in Patients With Chronic Lymphocytic Leukemia. JAMA Oncol. 2015 Apr; 1(1):80-7.
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The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor. Mol Biol Cell. 2014 Mar; 25(6):739-52.
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The B cell antigen receptor regulates the transcriptional activator beta-catenin via protein kinase C-mediated inhibition of glycogen synthase kinase-3. J Immunol. 2002 Jul 15; 169(2):758-69.
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The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways. Mol Cell Biol. 2002 Apr; 22(8):2524-35.
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Tight binding inhibition of protein phosphatase-1 by phosphatidic acid. Specificity of inhibition by the phospholipid. J Biol Chem. 2002 May 03; 277(18):15530-8.
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Proteolytic cleavage of phospholipase C-gamma1 during apoptosis in Molt-4 cells. FASEB J. 2000 Jun; 14(9):1083-92.
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Activation of the Rap1 GTPase by the B cell antigen receptor. J Biol Chem. 1998 Oct 30; 273(44):29218-23.