"Protein Kinase C-epsilon" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein kinase C subtype that was originally characterized as a CALCIUM-independent, serine-threonine kinase that is activated by PHORBOL ESTERS and DIACYLGLYCEROLS. It is targeted to specific cellular compartments in response to extracellular signals that activate G-PROTEIN-COUPLED RECEPTORS; TYROSINE KINASE RECEPTORS; and intracellular protein tyrosine kinase.
| Descriptor ID |
D051744
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.725.750
|
| Concept/Terms |
Protein Kinase C-epsilon- Protein Kinase C-epsilon
- Kinase C-epsilon, Protein
- PKC-epsilon Serine Threonine Kinase
- PKC epsilon Serine Threonine Kinase
- Protein Kinase C epsilon
- PKC epsilon
|
Below are MeSH descriptors whose meaning is more general than "Protein Kinase C-epsilon".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C-epsilon".
This graph shows the total number of publications written about "Protein Kinase C-epsilon" by people in this website by year, and whether "Protein Kinase C-epsilon" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 3 | 3 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Kinase C-epsilon" by people in Profiles.
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mTOR complex 2 mediates Akt phosphorylation that requires PKCe in adult cardiac muscle cells. Cell Signal. 2013 Sep; 25(9):1904-12.
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Enhanced PKCe mediated phosphorylation of connexin43 at serine 368 by a carboxyl-terminal mimetic peptide is dependent on injury. Channels (Austin). 2011 May-Jun; 5(3):236-40.
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A peptide mimetic of the connexin43 carboxyl terminus reduces gap junction remodeling and induced arrhythmia following ventricular injury. Circ Res. 2011 Mar 18; 108(6):704-15.
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Role of protein kinase C epsilon (PKCvarepsilon) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell. Psychopharmacology (Berl). 2009 Jul; 204(4):587-97.
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Role of PKCepsilon in PGF2alpha-stimulated MMP-2 secretion from human ciliary muscle cells. J Ocul Pharmacol Ther. 2008 Jun; 24(3):268-77.
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Altered PKC expression and phosphorylation in response to the nature, direction, and magnitude of mechanical stretch. Can J Physiol Pharmacol. 2007 Feb; 85(2):243-50.
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Protein kinase C isoform activation and endothelin-1 mediated defects in myocyte contractility after cardioplegic arrest and reperfusion. Circulation. 2006 Jul 04; 114(1 Suppl):I308-13.
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PKC translocation and ERK1/2 activation in compensated right ventricular hypertrophy secondary to chronic emphysema. BMC Physiol. 2005 May 05; 5(1):6.
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Opposing effects of protein kinase Calpha and protein kinase Cepsilon on collagen expression by human lung fibroblasts are mediated via MEK/ERK and caveolin-1 signaling. J Biol Chem. 2005 Apr 08; 280(14):13879-87.
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Distinct PKC isoforms mediate cell survival and DNA synthesis in thrombin-induced myofibroblasts. Am J Physiol Lung Cell Mol Physiol. 2005 Jan; 288(1):L190-201.