Neurotransmitter Uptake Inhibitors
"Neurotransmitter Uptake Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Drugs that inhibit the transport of neurotransmitters into axon terminals or into storage vesicles within terminals. For many transmitters, uptake determines the time course of transmitter action so inhibiting uptake prolongs the activity of the transmitter. Blocking uptake may also deplete available transmitter stores. Many clinically important drugs are uptake inhibitors although the indirect reactions of the brain rather than the acute block of uptake itself is often responsible for the therapeutic effects.
| Descriptor ID |
D014179
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| MeSH Number(s) |
D27.505.519.562.437 D27.505.519.625.600 D27.505.696.577.600
|
| Concept/Terms |
Neurotransmitter Uptake Inhibitors- Neurotransmitter Uptake Inhibitors
- Uptake Inhibitors, Neurotransmitter
- Reuptake Inhibitors, Neurotransmitter
- Inhibitors, Neurotransmitter Reuptake
- Neurotransmitter Reuptake Inhibitors
- Transmitter Uptake Inhibitors, Neuronal
- Inhibitors, Neurotransmitter Uptake
|
Below are MeSH descriptors whose meaning is more general than "Neurotransmitter Uptake Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "Neurotransmitter Uptake Inhibitors".
This graph shows the total number of publications written about "Neurotransmitter Uptake Inhibitors" by people in this website by year, and whether "Neurotransmitter Uptake Inhibitors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1998 | 2 | 0 | 2 |
| 1999 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Neurotransmitter Uptake Inhibitors" by people in Profiles.
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Glutamate Transporter GLT-1 as a Therapeutic Target for Substance Use Disorders. CNS Neurol Disord Drug Targets. 2015; 14(6):745-56.
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Presynaptic kappa-opioid and muscarinic receptors inhibit the calcium-dependent component of evoked glutamate release from striatal synaptosomes. J Neurochem. 1999 Sep; 73(3):1058-65.
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Cocaine discrimination: relationship to local anesthetics and monoamine uptake inhibitors in C57BL/6 mice. Psychopharmacology (Berl). 1998 Mar; 136(1):44-9.
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Kappa receptor activation attenuates L-trans-pyrrolidine-2,4-dicarboxylic acid-evoked glutamate levels in the striatum. J Neurochem. 1998 Feb; 70(2):626-34.
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L-trans-pyrrolidine-2,4-dicarboxylic acid-evoked striatal glutamate levels are attenuated by calcium reduction, tetrodotoxin, and glutamate receptor blockade. J Neurochem. 1997 Apr; 68(4):1553-63.
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Lack of efficacy of the adenosine reuptake inhibitor dipyridamole in the treatment of anxiety disorders. Biol Psychiatry. 1993 Apr 15-May 1; 33(8-9):647-50.