"Homeobox Protein Nkx-2.5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A homeobox-containing transcription factor that functions in heart development. Mutations in the NKX2-5 gene are associated with ATRIAL SEPTAL DEFECTS and TETRALOGY OF FALLOT.
| Descriptor ID |
D000072576
|
| MeSH Number(s) |
D12.776.260.400.234 D12.776.930.324
|
| Concept/Terms |
Homeobox Protein Nkx-2.5- Homeobox Protein Nkx-2.5
- Homeobox Protein Nkx 2.5
- Nkx-2.5, Homeobox Protein
- NK2 Homeobox 5 Protein
- Homeobox Transcription Factor Csx-Nkx2-5
- Homeobox Transcription Factor Csx Nkx2 5
- Homeobox Protein Csx-Nkx2.5
- Csx-Nkx2.5, Homeobox Protein
- Homeobox Protein Csx Nkx2.5
- Cardiac-Specific Homeobox Protein
- Cardiac Specific Homeobox Protein
- Homeobox Protein, Cardiac-Specific
- Transcription Factor Nkx-2.5
- Nkx-2.5, Transcription Factor
- Transcription Factor Nkx 2.5
|
Below are MeSH descriptors whose meaning is more general than "Homeobox Protein Nkx-2.5".
Below are MeSH descriptors whose meaning is more specific than "Homeobox Protein Nkx-2.5".
This graph shows the total number of publications written about "Homeobox Protein Nkx-2.5" by people in this website by year, and whether "Homeobox Protein Nkx-2.5" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 4 | 4 |
| 2015 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Homeobox Protein Nkx-2.5" by people in Profiles.
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Nkx2-5 Second Heart Field Target Gene Ccdc117 Regulates DNA Metabolism and Proliferation. Sci Rep. 2019 02 11; 9(1):1738.
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Evidence for a non-canonical role of HDAC5 in regulation of the cardiac Ncx1 and Bnp genes. Nucleic Acids Res. 2016 05 05; 44(8):3610-7.
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Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. Development. 2014 Aug; 141(15):2959-71.
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A mouse model of human congenital heart disease: high incidence of diverse cardiac anomalies and ventricular noncompaction produced by heterozygous Nkx2-5 homeodomain missense mutation. Circ Cardiovasc Genet. 2014 Aug; 7(4):423-433.
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Placental Nkx2-5 and target gene expression in early-onset and severe preeclampsia. Hypertens Pregnancy. 2014 Nov; 33(4):412-26.
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Novel and highly lethal NKX2.5 missense mutation in a family with sudden death and ventricular arrhythmia. Pediatr Cardiol. 2014 Oct; 35(7):1206-12.
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Nkx genes are essential for maintenance of ventricular identity. Development. 2013 Oct; 140(20):4203-13.
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Evolutionary conservation of Nkx2.5 autoregulation in the second heart field. Dev Biol. 2013 Feb 01; 374(1):198-209.
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Accessory atrioventricular myocardial pathways in mouse heart development: substrate for supraventricular tachycardias. Pediatr Res. 2011 Jul; 70(1):37-43.
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Jarid2 is among a set of genes differentially regulated by Nkx2.5 during outflow tract morphogenesis. Dev Dyn. 2010 Jul; 239(7):2024-33.