"DNA Glycosylases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of DNA repair enzymes that recognize damaged nucleotide bases and remove them by hydrolyzing the N-glycosidic bond that attaches them to the sugar backbone of the DNA molecule. The process called BASE EXCISION REPAIR can be completed by a DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE which excises the remaining RIBOSE sugar from the DNA.
| Descriptor ID |
D045647
|
| MeSH Number(s) |
D08.811.074.249 D08.811.277.450.430.099
|
| Concept/Terms |
DNA Glycosylases- DNA Glycosylases
- Glycosylases, DNA
- DNA Glycosylase
- Glycosylase, DNA
- DNA N-glycosidase
- DNA N glycosidase
|
Below are MeSH descriptors whose meaning is more general than "DNA Glycosylases".
Below are MeSH descriptors whose meaning is more specific than "DNA Glycosylases".
This graph shows the total number of publications written about "DNA Glycosylases" by people in this website by year, and whether "DNA Glycosylases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 |
| 2003 | 1 | 1 | 2 |
| 2004 | 1 | 1 | 2 |
| 2005 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 2 | 3 |
| 2016 | 2 | 0 | 2 |
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Below are the most recent publications written about "DNA Glycosylases" by people in Profiles.
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Prevalence and Penetrance of Major Genes and Polygenes for Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2017 03; 26(3):404-412.
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Risk of extracolonic cancers for people with biallelic and monoallelic mutations in MUTYH. Int J Cancer. 2016 10 01; 139(7):1557-63.
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Risk of colorectal cancer for people with a mutation in both a MUTYH and a DNA mismatch repair gene. Fam Cancer. 2015 Dec; 14(4):575-83.
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The role of base excision repair in pathogenesis of breast cancer in the Polish population. Mol Carcinog. 2016 12; 55(12):1899-1914.
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Germline TP53 Mutations in Patients With Early-Onset Colorectal Cancer in the Colon Cancer Family Registry. JAMA Oncol. 2015 May; 1(2):214-21.
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Risk of colorectal cancer for carriers of mutations in MUTYH, with and without a family history of cancer. Gastroenterology. 2014 May; 146(5):1208-11.e1-5.
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Advances in understanding the coupling of DNA base modifying enzymes to processes involving base excision repair. Adv Cancer Res. 2013; 119:63-106.
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Cancer risks for monoallelic MUTYH mutation carriers with a family history of colorectal cancer. Int J Cancer. 2011 Nov 01; 129(9):2256-62.
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Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat. Cancer Epidemiol Biomarkers Prev. 2010 Dec; 19(12):3167-73.
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Identification of Escherichia coli mismatch-specific uracil DNA glycosylase as a robust xanthine DNA glycosylase. J Biol Chem. 2010 Dec 31; 285(53):41483-90.