John Hildebrandt

Title
InstitutionMedical University of South Carolina
DepartmentCell and Molecular Pharmacology and Experimental Therapeutics
AddressP.O. Box MSC 509
173 Ashley Ave.
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Cleator JH, Wells CA, Dingus J, Kurtz DT, Hildebrandt JD. The N54-as Mutant Has Decreased Affinity for ß? and Suggests a Mechanism for Coupling Heterotrimeric G Protein Nucleotide Exchange with Subunit Dissociation. J Pharmacol Exp Ther. 2018 05; 365(2):219-225. PMID: 29491039.
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    2. Dingus J, Hildebrandt JD. Synthesis and assembly of G protein ß? dimers: comparison of in vitro and in vivo studies. Subcell Biochem. 2012; 63:155-80. PMID: 23161138.
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    3. Rose KM, Wang Z, Magrath GN, Hazard ES, Hildebrandt JD, Schey KL. Aquaporin 0-calmodulin interaction and the effect of aquaporin 0 phosphorylation. Biochemistry. 2008 Jan 08; 47(1):339-47. PMID: 18081321.
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    4. Kilpatrick EL, Hildebrandt JD. Sequence dependence and differential expression of Ggamma5 subunit isoforms of the heterotrimeric G proteins variably processed after prenylation in mammalian cells. J Biol Chem. 2007 May 11; 282(19):14038-47. PMID: 17353195.
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    5. Wells CA, Dingus J, Hildebrandt JD. Role of the chaperonin CCT/TRiC complex in G protein betagamma-dimer assembly. J Biol Chem. 2006 Jul 21; 281(29):20221-32. PMID: 16702223.
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    6. Hildebrandt JD. Bring your own G protein. Mol Pharmacol. 2006 Apr; 69(4):1079-82. PMID: 16436587.
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    7. Cook LA, Schey KL, Wilcox MD, Dingus J, Ettling R, Nelson T, Knapp DR, Hildebrandt JD. Proteomic analysis of bovine brain G protein gamma subunit processing heterogeneity. Mol Cell Proteomics. 2006 Apr; 5(4):671-85. PMID: 16332732.
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    8. Dingus J, Wells CA, Campbell L, Cleator JH, Robinson K, Hildebrandt JD. G Protein betagamma dimer formation: Gbeta and Ggamma differentially determine efficiency of in vitro dimer formation. Biochemistry. 2005 Sep 06; 44(35):11882-90. PMID: 16128590.
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    9. Yang W, Hildebrandt JD. Genomic analysis of G protein gamma subunits in human and mouse - the relationship between conserved gene structure and G protein betagamma dimer formation. Cell Signal. 2006 Feb; 18(2):194-201. PMID: 16006100.
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    10. Yang W, White B, Spicer EK, Weinstein BL, Hildebrandt JD. Complex haplotype structure of the human GNAS gene identifies a recombination hotspot centred on a single nucleotide polymorphism widely used in association studies. Pharmacogenetics. 2004 Nov; 14(11):741-7. PMID: 15564881.
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    11. Cleator JH, Ravenell R, Kurtz DT, Hildebrandt JD. A dominant negative Galphas mutant that prevents thyroid-stimulating hormone receptor activation of cAMP production and inositol 1,4,5-trisphosphate turnover: competition by different G proteins for activation by a common receptor. J Biol Chem. 2004 Aug 27; 279(35):36601-7. PMID: 15234971.
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    12. Hamilton MH, Cook LA, McRackan TR, Schey KL, Hildebrandt JD. Gamma 2 subunit of G protein heterotrimer is an N-end rule ubiquitylation substrate. Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9):5081-6. PMID: 12700354.
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    13. Ribas C, Takesono A, Sato M, Hildebrandt JD, Lanier SM. Pertussis toxin-insensitive activation of the heterotrimeric G-proteins Gi/Go by the NG108-15 G-protein activator. J Biol Chem. 2002 Dec 27; 277(52):50223-5. PMID: 12426323.
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    14. McIntire WE, Schey KL, Knapp DR, Dingus J, Hildebrandt JD. Characterization of deamidated G protein subunits. Methods Enzymol. 2002; 344:481-505. PMID: 11771405.
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    15. Schey KL, Busman M, Cook LA, Hamm HE, Hildebrandt JD. Structural characterization of intact G protein gamma subunits by mass spectrometry. Methods Enzymol. 2002; 344:586-97. PMID: 11771413.
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    16. Cook LA, Wilcox MD, Dingus J, Schey KL, Hildebrandt JD. Separation and analysis of G protein gamma subunits. Methods Enzymol. 2002; 344:209-33. PMID: 11771385.
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    17. Ribas C, Sato M, Hildebrandt JD, Lanier SM. Analysis of signal transfer from receptor to Go/Gi in different membrane environments and receptor-independent activators of brain G protein. Methods Enzymol. 2002; 344:140-52. PMID: 11771378.
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    18. Cook LA, Schey KL, Cleator JH, Wilcox MD, Dingus J, Hildebrandt JD. Identification of a region in G protein gamma subunits conserved across species but hypervariable among subunit isoforms. Protein Sci. 2001 Dec; 10(12):2548-55. PMID: 11714923.
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    19. Wu G, Bogatkevich GS, Mukhin YV, Benovic JL, Hildebrandt JD, Lanier SM. Identification of Gbetagamma binding sites in the third intracellular loop of the M(3)-muscarinic receptor and their role in receptor regulation. J Biol Chem. 2000 Mar 24; 275(12):9026-34. PMID: 10722752.
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    20. McIntire WE, Dingus J, Wilcox MD, Hildebrandt JD. The relationship of G(o)alpha subunit deamidation to the tissue distribution, nucleotide binding properties, and betagamma dimer interactions of G(o)alpha subunit isoforms. J Neurochem. 1999 Aug; 73(2):633-40. PMID: 10428059.
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    21. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 6321456.
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    22. Cleator JH, Mehta ND, Kurtz DT, Hildebrandt JD. The N54 mutant of Galphas has a conditional dominant negative phenotype which suppresses hormone-stimulated but not basal cAMP levels. FEBS Lett. 1999 Jan 25; 443(2):205-8. PMID: 9989606.
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    23. McIntire WE, Dingus J, Schey KL, Hildebrandt JD. Characterization of the major bovine brain Go alpha isoforms. Mapping the structural differences between the alpha subunit isoforms identifies a variable region of the protein involved in receptor interactions. J Biol Chem. 1998 Dec 11; 273(50):33135-41. PMID: 9837880.
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    24. McIntire WE, Schey KL, Knapp DR, Hildebrandt JD. A major G protein alpha O isoform in bovine brain is deamidated at Asn346 and Asn347, residues involved in receptor coupling. Biochemistry. 1998 Oct 20; 37(42):14651-8. PMID: 9778339.
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    25. Cook LA, Schey KL, Wilcox MD, Dingus J, Hildebrandt JD. Heterogeneous processing of a G protein gamma subunit at a site critical for protein and membrane interactions. Biochemistry. 1998 Sep 01; 37(35):12280-6. PMID: 9724542.
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    26. Wu G, Benovic JL, Hildebrandt JD, Lanier SM. Receptor docking sites for G-protein betagamma subunits. Implications for signal regulation. J Biol Chem. 1998 Mar 27; 273(13):7197-200. PMID: 9516410.
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    27. Hildebrandt JD. Role of subunit diversity in signaling by heterotrimeric G proteins. Biochem Pharmacol. 1997 Aug 01; 54(3):325-39. PMID: 9278091.
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    28. Chen Y, Weng G, Li J, Harry A, Pieroni J, Dingus J, Hildebrandt JD, Guarnieri F, Weinstein H, Iyengar R. A surface on the G protein beta-subunit involved in interactions with adenylyl cyclases. Proc Natl Acad Sci U S A. 1997 Mar 18; 94(6):2711-4. PMID: 9122261.
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    29. Sato M, Ribas C, Hildebrandt JD, Lanier SM. Characterization of a G-protein activator in the neuroblastoma-glioma cell hybrid NG108-15. J Biol Chem. 1996 Nov 22; 271(47):30052-60. PMID: 8939952.
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    30. Weng G, Li J, Dingus J, Hildebrandt JD, Weinstein H, Iyengar R. Gbeta subunit interacts with a peptide encoding region 956-982 of adenylyl cyclase 2. Cross-linking of the peptide to free Gbetagamma but not the heterotrimer. J Biol Chem. 1996 Oct 25; 271(43):26445-8. PMID: 8900107.
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    31. Makhlouf M, Ashton SH, Hildebrandt J, Mehta N, Gettys TW, Halushka PV, Cook JA. Alterations in macrophage G proteins are associated with endotoxin tolerance. Biochim Biophys Acta. 1996 Jun 13; 1312(2):163-8. PMID: 8672540.
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    32. Wilcox MD, Schey KL, Busman M, Hildebrandt JD. Determination of the complete covalent structure of the gamma 2 subunit of bovine brain G proteins by mass spectrometry. Biochem Biophys Res Commun. 1995 Jul 17; 212(2):367-74. PMID: 7626050.
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    33. Sato M, Kataoka R, Dingus J, Wilcox M, Hildebrandt JD, Lanier SM. Factors determining specificity of signal transduction by G-protein-coupled receptors. Regulation of signal transfer from receptor to G-protein. J Biol Chem. 1995 Jun 23; 270(25):15269-76. PMID: 7797513.
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    34. Mullikin-Kilpatrick D, Mehta ND, Hildebrandt JD, Treistman SN. Gi is involved in ethanol inhibition of L-type calcium channels in undifferentiated but not differentiated PC-12 cells. Mol Pharmacol. 1995 May; 47(5):997-1005. PMID: 7746286.
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    35. Wilcox MD, Dingus J, Balcueva EA, McIntire WE, Mehta ND, Schey KL, Robishaw JD, Hildebrandt JD. Bovine brain GO isoforms have distinct gamma subunit compositions. J Biol Chem. 1995 Mar 03; 270(9):4189-92. PMID: 7876173.
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    36. Wilcox MD, Schey KL, Dingus J, Mehta ND, Tatum BS, Halushka M, Finch JW, Hildebrandt JD. Analysis of G protein gamma subunit heterogeneity using mass spectrometry. J Biol Chem. 1994 Apr 29; 269(17):12508-13. PMID: 8175659.
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    37. Zhang LM, Newman WH, Castresana MR, Hildebrandt JD. The effect of pertussis toxin on the growth of vascular smooth muscle cells stimulated by serum or platelet-derived growth factor. Endocrinology. 1994 Mar; 134(3):1297-304. PMID: 8119169.
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    38. Dingus J, Wilcox MD, Kohnken R, Hildebrandt JD. Synthesis and use of biotinylated beta gamma complexes prepared from bovine brain G proteins. Methods Enzymol. 1994; 237:457-71. PMID: 7935020.
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    39. Hildebrandt JD, Day R, Farnsworth CL, Feig LA. A mutation in the putative Mg(2+)-binding site of Gs alpha prevents its activation by receptors. Mol Cell Biol. 1991 Oct; 11(10):4830-8. PMID: 1656212.
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    40. Hildebrandt JD, Lederman L, Steffen DL. Effect of ras-gene transformation on the inhibition of NIH3T3 cell growth by pertussis toxin. Mol Endocrinol. 1991 Aug; 5(8):1101-8. PMID: 1944306.
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    41. Padrell E, Carty DJ, Moriarty TM, Hildebrandt JD, Landau EM, Iyengar R. Two forms of the bovine brain Go that stimulate the inositol trisphosphate-mediated Cl- currents in Xenopus oocytes. Distinct guanine nucleotide binding properties. J Biol Chem. 1991 May 25; 266(15):9771-7. PMID: 1851756.
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    42. Allworth AE, Hildebrandt JD, Ziomek CA. Differential regulation of G protein subunit expression in mouse oocytes, eggs, and early embryos. Dev Biol. 1990 Nov; 142(1):129-37. PMID: 2121565.
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    43. Hildebrandt JD, Kohnken RE. Hormone inhibition of adenylyl cyclase. Differences in the mechanisms for inhibition by hormones and G protein beta gamma. J Biol Chem. 1990 Jun 15; 265(17):9825-30. PMID: 1972156.
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    44. Carty DJ, Padrell E, Codina J, Birnbaumer L, Hildebrandt JD, Iyengar R. Distinct guanine nucleotide binding and release properties of the three Gi proteins. J Biol Chem. 1990 Apr 15; 265(11):6268-73. PMID: 2108158.
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    45. Kohnken RE, Hildebrandt JD. G protein subunit interactions. Studies with biotinylated G protein subunits. J Biol Chem. 1989 Dec 05; 264(34):20688-96. PMID: 2511209.
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    46. Hildebrandt JD, Stolzenberg E, Graves J. Pertussis toxin alters the growth characteristics of Swiss 3T3 cells. FEBS Lett. 1986 Jul 14; 203(1):87-90. PMID: 3087783.
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    47. Hildebrandt JD, Codina J, Rosenthal W, Birnbaumer L, Neer EJ, Yamazaki A, Bitensky MW. Characterization by two-dimensional peptide mapping of the gamma subunits of Ns and Ni, the regulatory proteins of adenylyl cyclase, and of transducin, the guanine nucleotide-binding protein of rod outer segments of the eye. J Biol Chem. 1985 Nov 25; 260(27):14867-72. PMID: 3932359.
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    48. Codina J, Rosenthal W, Hildebrandt JD, Birnbaumer L, Sekura RD. Purification of Ns and Ni, the coupling proteins of hormone-sensitive adenylyl cyclases without intervention of activating regulatory ligands. Methods Enzymol. 1985; 109:446-65. PMID: 3921803.
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    49. Ribeiro-Neto FA, Mattera R, Hildebrandt JD, Codina J, Field JB, Birnbaumer L, Sekura RD. ADP-ribosylation of membrane components by pertussis and cholera toxin. Methods Enzymol. 1985; 109:566-72. PMID: 2859516.
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    50. Hildebrandt JD, Codina J, Birnbaumer L. Interaction of the stimulatory and inhibitory regulatory proteins of the adenylyl cyclase system with the catalytic component of cyc-S49 cell membranes. J Biol Chem. 1984 Nov 10; 259(21):13178-85. PMID: 6436244.
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    51. Codina J, Hildebrandt JD, Birnbaumer L, Sekura RD. Effects of guanine nucleotides and Mg on human erythrocyte Ni and Ns, the regulatory components of adenylyl cyclase. J Biol Chem. 1984 Sep 25; 259(18):11408-18. PMID: 6381498.
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    52. Rich KA, Codina J, Floyd G, Sekura R, Hildebrandt JD, Iyengar R. Glucagon-induced heterologous desensitization of the MDCK cell adenylyl cyclase. Increases in the apparent levels of the inhibitory regulator (Ni). J Biol Chem. 1984 Jun 25; 259(12):7893-901. PMID: 6539777.
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    53. Codina J, Rosenthal W, Hildebrandt JD, Sekura RD, Birnbaumer L. Updated protocols and comments on the purification without use of activating ligands of the coupling proteins Ns and Ni of the hormone sensitive adenylyl cyclase. J Recept Res. 1984; 4(1-6):411-42. PMID: 6098665.
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    54. Codina J, Hildebrandt J, Sunyer T, Sekura RD, Manclark CR, Iyengar R, Birnbaumer L. Mechanisms in the vectorial receptor-adenylate cyclase signal transduction. Adv Cyclic Nucleotide Protein Phosphorylation Res. 1984; 17:111-25. PMID: 6145316.
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    55. Hildebrandt JD, Birnbaumer L. Inhibitory regulation of adenylyl cyclase in the absence of stimulatory regulation. Requirements and kinetics of guanine nucleotide-induced inhibition of the cyc- S49 adenylyl cyclase. J Biol Chem. 1983 Nov 10; 258(21):13141-7. PMID: 6685126.
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    56. Codina J, Hildebrandt J, Iyengar R, Birnbaumer L, Sekura RD, Manclark CR. Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium. Proc Natl Acad Sci U S A. 1983 Jul; 80(14):4276-80. PMID: 6308612.
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    57. Hildebrandt JD, Sekura RD, Codina J, Iyengar R, Manclark CR, Birnbaumer L. Stimulation and inhibition of adenylyl cyclases mediated by distinct regulatory proteins. Nature. 1983 Apr 21; 302(5910):706-9. PMID: 6300694.
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    58. Hildebrandt JD, Hanoune J, Birnbaumer L. Guanine nucleotide inhibition of cyc- S49 mouse lymphoma cell membrane adenylyl cyclase. J Biol Chem. 1982 Dec 25; 257(24):14723-5. PMID: 6757248.
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    59. Somkuti SG, Hildebrandt JD, Herberg JT, Iyengar R. Divalent cation regulation of adenylyl cyclase. An allosteric site on the catalytic component. J Biol Chem. 1982 Jun 10; 257(11):6387-93. PMID: 6804466.
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