Perry V. Halushka

TitleDean Emeritus, College of Graduate Studies
InstitutionMedical University of South Carolina
DepartmentCell and Molecular Pharmacology and Experimental Therapeutics
AddressP.O. Box MSC 501
BE 101
68 President St.
Phone843-876-2405
Fax843-876-2416
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    Collapse Biography 
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    1984 - 1989Burroughs Wellcome Scholar in Clinical Pharmacology, musc
    1995Association of American Physicians

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    Perry V. Halushka, M.D., Ph.D. is a Distinguished University Professor of Cell and Molecular Pharmacology, the Program Director of Medical Scientist Training Program, and dean emeritus of the College of Graduate Studies. He received his Ph.D. degree in 1967 and M.D. degree in 1970 from the University of Chicago. After internship and residency in Internal Medicine at Grady Memorial Hospital, he spent two years at the NIH, Experimental Therapeutics Branch. In 1974, he joined the faculty of the Medical University of South Carolina.

    Dr. Halushka¹s research has revolved around molecular characterizations and regulation of Thromboxane A2 receptors in health and disease. "The long term objective of our research program is to determine the role of thromboxane A2 receptors in disease processes with a particular emphasis in cancer. In collaboration with Drs. Omar Moussa and Dennis Watson we have found that there is an over-expression of the beta isoform of thromboxane A2 receptors in bladder cancer tissue and cell lines. The over-expression is associated with a poorer prognosis in patients with bladder cancer. Current studies are focused on determining the mechanisms for: 1) the over-expression of the receptors and 2) the signaling pathways involved in the oncogenic effects. The observations made in these studies may have wider applicability to other cancers."
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    Molecular Characterization, Regulation of Thromboxane A2 Receptors in Health and Disease

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Li P, Wu Y, Goodwin AJ, Halushka PV, Wilson CL, Schnapp LM, Fan H. Generation of a new immortalized human lung pericyte cell line: a promising tool for human lung pericyte studies. Lab Invest. 2021 May; 101(5):625-635. PMID: 36775384.
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    2. Wu Y, Li P, Liu L, Goodwin AJ, Halushka PV, Hirose T, Nakagawa S, Zhou J, Liu M, Fan H, Wu Y, Li P, Liu L, Goodwin AJ, Halushka PV, Hirose T, Nakagawa S, Zhou J, Liu M, Fan H. lncRNA Neat1 regulates neuronal dysfunction post-sepsis via stabilization of hemoglobin subunit beta. Mol Ther. 2022 07 06; 30(7):2618-2632. PMID: 35331906; PMCID: PMC9263235.
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    3. Li P, Wu Y, Hamlett ED, Goodwin AJ, Halushka PV, Carroll SL, Liu M, Fan H, Li P, Wu Y, Hamlett ED, Goodwin AJ, Halushka PV, Carroll SL, Liu M, Fan H. Suppression of Fli-1 protects against pericyte loss and cognitive deficits in Alzheimer's disease. Mol Ther. 2022 04 06; 30(4):1451-1464. PMID: 35038582; PMCID: PMC9077320.
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    4. Li P, Wu Y, Goodwin AJ, Halushka PV, Wilson CL, Schnapp LM, Fan H, Li P, Wu Y, Goodwin AJ, Halushka PV, Wilson CL, Schnapp LM, Fan H. Generation of a new immortalized human lung pericyte cell line: a promising tool for human lung pericyte studies. Lab Invest. 2021 05; 101(5):625-635. PMID: 33446892; PMCID: PMC8068576.
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    5. Currie MG, Zimmer DP, Halushka PV, Currie MG, Zimmer DP, Halushka PV. An impaired natriuretic peptide hormone system may play a role in COVID-19 severity in vulnerable populations. FASEB Bioadv. 2020 Oct; 2(10):596-599. PMID: 32838215; PMCID: PMC7436750.
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    6. Halushka P, Loucks TL, Paranal R, Harvey J, Briggman K, Lee-Chavarria D, Feghali-Bostwick C, Halushka P, Loucks TL, Paranal R, Harvey J, Briggman K, Lee-Chavarria D, Feghali-Bostwick C. The translational sciences clinic: From bench to bedside. J Clin Transl Sci. 2020 Aug 25; 5(1):e36. PMID: 33948258; PMCID: PMC8057442.
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    7. Wu Y, Li P, Goodwin AJ, Cook JA, Halushka PV, Zingarelli B, Fan H, Wu Y, Li P, Goodwin AJ, Cook JA, Halushka PV, Zingarelli B, Fan H. miR-145a Regulation of Pericyte Dysfunction in a Murine Model of Sepsis. J Infect Dis. 2020 08 17; 222(6):1037-1045. PMID: 32285112; PMCID: PMC7430167.
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    8. Goodwin AJ, Li P, Halushka PV, Cook JA, Sumal AS, Fan H, Goodwin AJ, Li P, Halushka PV, Cook JA, Sumal AS, Fan H. Circulating miRNA 887 is differentially expressed in ARDS and modulates endothelial function. Am J Physiol Lung Cell Mol Physiol. 2020 06 01; 318(6):L1261-L1269. PMID: 32321279; PMCID: PMC7347270.
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    9. Bonilha H, Hyer M, Krug E, Mauldin M, Edlund B, Martin-Harris B, Halushka P, McGinty J, Sullivan J, Brady K, Ranwala D, Hermayer K, Harvey J, Paranal R, Gough J, Silvestri G, Chimowitz M, Bonilha H, Hyer M, Krug E, Mauldin M, Edlund B, Martin-Harris B, Halushka P, McGinty J, Sullivan J, Brady K, Ranwala D, Hermayer K, Harvey J, Paranal R, Gough J, Silvestri G, Chimowitz M. An institution-wide faculty mentoring program at an academic health center with 6-year prospective outcome data - ADDENDUM. J Clin Transl Sci. 2020 Mar 31; 4(4):370. PMID: 33244421; PMCID: PMC7681151.
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    10. Bonilha H, Hyer M, Krug E, Mauldin M, Edlund B, Martin-Harris B, Halushka P, McGinty J, Sullivan J, Brady K, Ranwala D, Hermayer K, Harvey J, Paranal R, Gough J, Silvestri G, Chimowitz M, Bonilha H, Hyer M, Krug E, Mauldin M, Edlund B, Martin-Harris B, Halushka P, McGinty J, Sullivan J, Brady K, Ranwala D, Hermayer K, Harvey J, Paranal R, Gough J, Silvestri G, Chimowitz M. An institution-wide faculty mentoring program at an academic health center with 6-year prospective outcome data. J Clin Transl Sci. 2019 Dec; 3(6):308-315. PMID: 31827904; PMCID: PMC6885994.
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    11. Feghali-Bostwick C, Harvey J, Hasseler C, Lee-Chavarria D, Halushka P, Feghali-Bostwick C, Harvey J, Hasseler C, Lee-Chavarria D, Halushka P. A team-based translational journal club: Understanding the translational research highway. J Clin Transl Sci. 2019 Dec; 3(6):291-294. PMID: 31827901; PMCID: PMC6885992.
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    12. Zhou Y, Li P, Goodwin AJ, Cook JA, Halushka PV, Chang E, Zingarelli B, Fan H, Zhou Y, Li P, Goodwin AJ, Cook JA, Halushka PV, Chang E, Zingarelli B, Fan H. Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury. Crit Care. 2019 02 13; 23(1):44. PMID: 30760290; PMCID: PMC6373158.
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    13. Li P, Goodwin AJ, Cook JA, Halushka PV, Zhang XK, Fan H, Li P, Goodwin AJ, Cook JA, Halushka PV, Zhang XK, Fan H. Fli-1 transcription factor regulates the expression of caspase-1 in lung pericytes. Mol Immunol. 2019 04; 108:1-7. PMID: 30739075; PMCID: PMC6409192.
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    14. Jones Buie JN, Zhou Y, Goodwin AJ, Cook JA, Vournakis J, Demcheva M, Broome AM, Dixit S, Halushka PV, Fan H, Jones Buie JN, Zhou Y, Goodwin AJ, Cook JA, Vournakis J, Demcheva M, Broome AM, Dixit S, Halushka PV, Fan H. Application of Deacetylated Poly-N-Acetyl Glucosamine Nanoparticles for the Delivery of miR-126 for the Treatment of Cecal Ligation and Puncture-Induced Sepsis. Inflammation. 2019 Feb; 42(1):170-184. PMID: 30244405; PMCID: PMC6380957.
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    15. Li P, Zhou Y, Goodwin AJ, Cook JA, Halushka PV, Zhang XK, Wilson CL, Schnapp LM, Zingarelli B, Fan H, Li P, Zhou Y, Goodwin AJ, Cook JA, Halushka PV, Zhang XK, Wilson CL, Schnapp LM, Zingarelli B, Fan H. Fli-1 Governs Pericyte Dysfunction in a Murine Model of Sepsis. J Infect Dis. 2018 11 05; 218(12):1995-2005. PMID: 30053030; PMCID: PMC6217724.
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    16. Halushka PV, Goodwin AJ, Halushka MK, Halushka PV, Goodwin AJ, Halushka MK. Opportunities for microRNAs in the Crowded Field of Cardiovascular Biomarkers. Annu Rev Pathol. 2019 01 24; 14:211-238. PMID: 30332561; PMCID: PMC6442682.
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    17. Zhou Y, Li P, Goodwin AJ, Cook JA, Halushka PV, Chang E, Fan H, Zhou Y, Li P, Goodwin AJ, Cook JA, Halushka PV, Chang E, Fan H. Exosomes from Endothelial Progenitor Cells Improve the Outcome of a Murine Model of Sepsis. Mol Ther. 2018 05 02; 26(5):1375-1384. PMID: 29599080; PMCID: PMC5993985.
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    18. Ranwala D, Alberg AJ, Brady KT, Obeid JS, Davis R, Halushka PV, Ranwala D, Alberg AJ, Brady KT, Obeid JS, Davis R, Halushka PV. Scientific retreats with 'speed dating': networking to stimulate new interdisciplinary translational research collaborations and team science. J Investig Med. 2017 02; 65(2):382-390. PMID: 27807146; PMCID: PMC5274553.
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    19. Jones Buie JN, Goodwin AJ, Cook JA, Halushka PV, Fan H, Jones Buie JN, Goodwin AJ, Cook JA, Halushka PV, Fan H. The role of miRNAs in cardiovascular disease risk factors. Atherosclerosis. 2016 11; 254:271-281. PMID: 27693002; PMCID: PMC5125538.
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    20. Guo C, Goodwin A, Buie JNJ, Cook J, Halushka P, Argraves K, Zingarelli B, Zhang X, Wang L, Fan H, Guo C, Goodwin A, Buie JNJ, Cook J, Halushka P, Argraves K, Zingarelli B, Zhang X, Wang L, Fan H. A Stromal Cell-Derived Factor 1a Analogue Improves Endothelial Cell Function in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome. Mol Med. 2016 Sep; 22:115-123. PMID: 27031787; PMCID: PMC5004713.
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    21. Goodwin AJ, Guo C, Cook JA, Wolf B, Halushka PV, Fan H, Goodwin AJ, Guo C, Cook JA, Wolf B, Halushka PV, Fan H. Plasma levels of microRNA are altered with the development of shock in human sepsis: an observational study. Crit Care. 2015 Dec 18; 19:440. PMID: 26683209; PMCID: PMC4699334.
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    22. Smolka AJ, Halushka PV, Garrett-Mayer E, Smolka AJ, Halushka PV, Garrett-Mayer E. The faculty costs to educate a biomedical sciences graduate student. CBE Life Sci Educ. 2015 Mar 02; 14(1):ar3. PMID: 25673355; PMCID: PMC4353078.
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    23. Sobolesky PM, Halushka PV, Garrett-Mayer E, Smith MT, Moussa O, Sobolesky PM, Halushka PV, Garrett-Mayer E, Smith MT, Moussa O. Regulation of the tumor suppressor FOXO3 by the thromboxane-A2 receptors in urothelial cancer. PLoS One. 2014; 9(9):e107530. PMID: 25202904; PMCID: PMC4159332.
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    24. Guan S, Guo C, Zingarelli B, Wang L, Halushka PV, Cook JA, Fan H, Guan S, Guo C, Zingarelli B, Wang L, Halushka PV, Cook JA, Fan H. Combined treatment with a CXCL12 analogue and antibiotics improves survival and neutrophil recruitment and function in murine sepsis. Immunology. 2014 Sep 08. PMID: 25201453; PMCID: PMC4557677.
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    25. Fan H, Goodwin AJ, Chang E, Zingarelli B, Borg K, Guan S, Halushka PV, Cook JA, Fan H, Goodwin AJ, Chang E, Zingarelli B, Borg K, Guan S, Halushka PV, Cook JA. Endothelial progenitor cells and a stromal cell-derived factor-1a analogue synergistically improve survival in sepsis. Am J Respir Crit Care Med. 2014 Jun 15; 189(12):1509-19. PMID: 24707934; PMCID: PMC4226015.
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    26. Manevich Y, Hutchens S, Halushka PV, Tew KD, Townsend DM, Jauch EC, Borg K, Manevich Y, Hutchens S, Halushka PV, Tew KD, Townsend DM, Jauch EC, Borg K. Peroxiredoxin VI oxidation in cerebrospinal fluid correlates with traumatic brain injury outcome. Free Radic Biol Med. 2014 Jul; 72:210-21. PMID: 24726861; PMCID: PMC4088265.
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    27. Li P, Neubig RR, Zingarelli B, Borg K, Halushka PV, Cook JA, Fan H, Li P, Neubig RR, Zingarelli B, Borg K, Halushka PV, Cook JA, Fan H. Toll-like receptor-induced inflammatory cytokines are suppressed by gain of function or overexpression of Ga(i2) protein. Inflammation. 2012 Oct; 35(5):1611-7. PMID: 22581266; PMCID: PMC3563060.
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    28. Fan H, Wong D, Ashton SH, Borg KT, Halushka PV, Cook JA, Fan H, Wong D, Ashton SH, Borg KT, Halushka PV, Cook JA. Beneficial effect of a CXCR4 agonist in murine models of systemic inflammation. Inflammation. 2012 Feb; 35(1):130-7. PMID: 21274742; PMCID: PMC3612970.
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    29. Moussa O, Ciupek A, Watson DK, Halushka PV, Moussa O, Ciupek A, Watson DK, Halushka PV. Urinary thromboxane B2 and thromboxane receptors in bladder cancer: opportunity for detection and monitoring. Prostaglandins Other Lipid Mediat. 2011 Nov; 96(1-4):41-4. PMID: 21983220; PMCID: PMC3215826.
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    30. Li P, Cook JA, Gilkeson GS, Luttrell LM, Wang L, Borg KT, Halushka PV, Fan H, Li P, Cook JA, Gilkeson GS, Luttrell LM, Wang L, Borg KT, Halushka PV, Fan H. Increased expression of beta-arrestin 1 and 2 in murine models of rheumatoid arthritis: isoform specific regulation of inflammation. Mol Immunol. 2011 Oct; 49(1-2):64-74. PMID: 21855149; PMCID: PMC3205331.
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    31. Oates JC, Halushka PV, Hutchison FN, Ruiz P, Gilkeson GS, Oates JC, Halushka PV, Hutchison FN, Ruiz P, Gilkeson GS. Selective cyclooxygenase-2 inhibitor suppresses renal thromboxane production but not proliferative lesions in the MRL/lpr murine model of lupus nephritis. Am J Med Sci. 2011 Feb; 341(2):101-5. PMID: 20924284; PMCID: PMC3022955.
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    32. Fan H, Li P, Zingarelli B, Borg K, Halushka PV, Birnbaumer L, Cook JA, Fan H, Li P, Zingarelli B, Borg K, Halushka PV, Birnbaumer L, Cook JA. Heterotrimeric Ga(i) proteins are regulated by lipopolysaccharide and are anti-inflammatory in endotoxemia and polymicrobial sepsis. Biochim Biophys Acta. 2011 Mar; 1813(3):466-72. PMID: 21255617; PMCID: PMC3046305.
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    33. Fan H, Bitto A, Zingarelli B, Luttrell LM, Borg K, Halushka PV, Cook JA, Fan H, Bitto A, Zingarelli B, Luttrell LM, Borg K, Halushka PV, Cook JA. Beta-arrestin 2 negatively regulates sepsis-induced inflammation. Immunology. 2010 Jul; 130(3):344-51. PMID: 20465566; PMCID: PMC2913214.
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    34. Halushka PV, Krug EL, Halushka PV, Krug EL. Is the training of biomedical scientists at a crossroads? Acad Med. 2009 Apr; 84(4):421-3. PMID: 19318769.
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    35. Fan H, Zingarelli B, Harris V, Tempel GE, Halushka PV, Cook JA, Fan H, Zingarelli B, Harris V, Tempel GE, Halushka PV, Cook JA. Lysophosphatidic acid inhibits bacterial endotoxin-induced pro-inflammatory response: potential anti-inflammatory signaling pathways. Mol Med. 2008 Jul-Aug; 14(7-8):422-8. PMID: 18431464; PMCID: PMC2323339.
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    36. Moussa O, Ashton AW, Fraig M, Garrett-Mayer E, Ghoneim MA, Halushka PV, Watson DK, Moussa O, Ashton AW, Fraig M, Garrett-Mayer E, Ghoneim MA, Halushka PV, Watson DK. Novel role of thromboxane receptors beta isoform in bladder cancer pathogenesis. Cancer Res. 2008 Jun 01; 68(11):4097-104. PMID: 18519668.
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    37. Basher F, Fan H, Zingarelli B, Borg KT, Luttrell LM, Tempel GE, Halushka PV, Cook JA, Basher F, Fan H, Zingarelli B, Borg KT, Luttrell LM, Tempel GE, Halushka PV, Cook JA. beta-Arrestin 2: a Negative Regulator of Inflammatory Responses in Polymorphonuclear Leukocytes. Int J Clin Exp Med. 2008; 1(1):32-41. PMID: 19079685; PMCID: PMC2596334.
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    38. Moussa O, Riker JM, Klein J, Fraig M, Halushka PV, Watson DK, Moussa O, Riker JM, Klein J, Fraig M, Halushka PV, Watson DK. Inhibition of thromboxane synthase activity modulates bladder cancer cell responses to chemotherapeutic agents. Oncogene. 2008 Jan 03; 27(1):55-62. PMID: 17603559.
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    39. Fan H, Williams DL, Zingarelli B, Breuel KF, Teti G, Tempel GE, Spicher K, Boulay G, Birnbaumer L, Halushka PV, Cook JA, Fan H, Williams DL, Zingarelli B, Breuel KF, Teti G, Tempel GE, Spicher K, Boulay G, Birnbaumer L, Halushka PV, Cook JA. Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Galpha(i) proteins. Immunology. 2007 Sep; 122(1):116-23. PMID: 17484771; PMCID: PMC2265979.
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    40. Fan H, Luttrell LM, Tempel GE, Senn JJ, Halushka PV, Cook JA, Fan H, Luttrell LM, Tempel GE, Senn JJ, Halushka PV, Cook JA. Beta-arrestins 1 and 2 differentially regulate LPS-induced signaling and pro-inflammatory gene expression. Mol Immunol. 2007 May; 44(12):3092-9. PMID: 17418896; PMCID: PMC1945129.
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    41. Fan H, Williams DL, Breuel KF, Zingarelli B, Teti G, Tempel GE, Halushka PV, Cook JA, Fan H, Williams DL, Breuel KF, Zingarelli B, Teti G, Tempel GE, Halushka PV, Cook JA. Gi proteins regulate lipopolysaccharide and Staphylococcus aureus induced cytokine production but not (1--> 3)-beta-D-glucan induced cytokine suppression. Front Biosci. 2006 Sep 01; 11:2264-74. PMID: 16720313.
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    42. Fan H, Williams DL, Zingarelli B, Breuel KF, Teti G, Tempel GE, Spicher K, Boulay G, Birnbaumer L, Halushka PV, Cook JA, Fan H, Williams DL, Zingarelli B, Breuel KF, Teti G, Tempel GE, Spicher K, Boulay G, Birnbaumer L, Halushka PV, Cook JA. Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins. Biochim Biophys Acta. 2006 Oct; 1763(10):1051-8. PMID: 16962188.
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    43. Peck OM, Zingarelli B, Fan H, Teti G, Tempel G, Halushka PV, Cook JA, Peck OM, Zingarelli B, Fan H, Teti G, Tempel G, Halushka PV, Cook JA. The phosphatidylinositol 3 kinase pathway regulates tolerance to lipopolysaccharide and priming responses to Staphylococcus aureus and lipopolysaccharide. Shock. 2006 Jul; 26(1):31-6. PMID: 16783195.
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    44. Halushka MK, Halushka PV, Halushka MK, Halushka PV. Toward individualized analgesic therapy: functional cyclooxygenase 1 and 2 haplotypes. Clin Pharmacol Ther. 2006 May; 79(5):404-6. PMID: 16678542.
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    45. Moussa O, Yordy JS, Abol-Enein H, Sinha D, Bissada NK, Halushka PV, Ghoneim MA, Watson DK, Moussa O, Yordy JS, Abol-Enein H, Sinha D, Bissada NK, Halushka PV, Ghoneim MA, Watson DK. Prognostic and functional significance of thromboxane synthase gene overexpression in invasive bladder cancer. Cancer Res. 2005 Dec 15; 65(24):11581-7. PMID: 16357168.
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    46. Ajayi AA, Halushka PV, Ajayi AA, Halushka PV. Castration reduces platelet thromboxane A2 receptor density and aggregability. QJM. 2005 May; 98(5):349-56. PMID: 15820970.
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    47. Fan H, Zingarelli B, Peck OM, Teti G, Tempel GE, Halushka PV, Spicher K, Boulay G, Birnbaumer L, Cook JA, Fan H, Zingarelli B, Peck OM, Teti G, Tempel GE, Halushka PV, Spicher K, Boulay G, Birnbaumer L, Cook JA. Lipopolysaccharide- and gram-positive bacteria-induced cellular inflammatory responses: role of heterotrimeric Galpha(i) proteins. Am J Physiol Cell Physiol. 2005 Aug; 289(2):C293-301. PMID: 15788486.
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    48. Malcolm R, LaRowe S, Cochran K, Moak D, Herron J, Brady K, Hedden S, Woolson R, Halushka P, Malcolm R, LaRowe S, Cochran K, Moak D, Herron J, Brady K, Hedden S, Woolson R, Halushka P. A controlled trial of amlodipine for cocaine dependence: a negative report. J Subst Abuse Treat. 2005 Mar; 28(2):197-204. PMID: 15780550.
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    49. Fan H, Peck OM, Tempel GE, Halushka PV, Cook JA, Fan H, Peck OM, Tempel GE, Halushka PV, Cook JA. Toll-like receptor 4 coupled GI protein signaling pathways regulate extracellular signal-regulated kinase phosphorylation and AP-1 activation independent of NFkappaB activation. Shock. 2004 Jul; 22(1):57-62. PMID: 15201703.
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    50. Peck OM, Fan H, Tempel GE, Teti G, Halushka PV, Cook JA, Peck OM, Fan H, Tempel GE, Teti G, Halushka PV, Cook JA. Staphylococcus aureus and lipopolysaccharide induce homologous tolerance but heterologous priming: role of interferon-gamma. Shock. 2004 Mar; 21(3):254-60. PMID: 14770039.
      Citations: 6     Fields:    Translation:HumansCells
    51. Taylor DM, Halushka PV, Meier GP, Taylor DM, Halushka PV, Meier GP. Hydrogen bond interactions of a series of N-substituted TXA2 receptor antagonists. Eur J Med Chem. 2003 Nov-Dec; 38(11-12):1015-24. PMID: 14642334.
      Citations:    Fields:    Translation:HumansCells
    52. Qiao N, Reynaud D, Demin P, Halushka PV, Pace-Asciak CR, Qiao N, Reynaud D, Demin P, Halushka PV, Pace-Asciak CR. The thromboxane receptor antagonist PBT-3, a hepoxilin stable analog, selectively antagonizes the TPalpha isoform in transfected COS-7 cells. J Pharmacol Exp Ther. 2003 Dec; 307(3):1142-7. PMID: 14560042.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    53. Guyton K, Zingarelli B, Ashton S, Teti G, Tempel G, Reilly C, Gilkeson G, Halushka P, Cook J, Guyton K, Zingarelli B, Ashton S, Teti G, Tempel G, Reilly C, Gilkeson G, Halushka P, Cook J. Peroxisome proliferator-activated receptor-gamma agonists modulate macrophage activation by gram-negative and gram-positive bacterial stimuli. Shock. 2003 Jul; 20(1):56-62. PMID: 12813370.
      Citations: 12     Fields:    Translation:AnimalsCells
    54. Fan H, Teti G, Ashton S, Guyton K, Tempel GE, Halushka PV, Cook JA, Fan H, Teti G, Ashton S, Guyton K, Tempel GE, Halushka PV, Cook JA. Involvement of G(i) proteins and Src tyrosine kinase in TNFalpha production induced by lipopolysaccharide, group B Streptococci and Staphylococcus aureus. Cytokine. 2003 Jun 07; 22(5):126-33. PMID: 12842760.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    55. Gale DD, Hofer P, Spina D, Seeds EA, Banner KH, Harrison S, Douglas G, Matsumoto T, Page CP, Wong RH, Jordan S, Smith F, Banik N, Halushka PV, Cavalla D, Rotshteyn Y, Kyle DJ, Burch RM, Chasin M, Gale DD, Hofer P, Spina D, Seeds EA, Banner KH, Harrison S, Douglas G, Matsumoto T, Page CP, Wong RH, Jordan S, Smith F, Banik N, Halushka PV, Cavalla D, Rotshteyn Y, Kyle DJ, Burch RM, Chasin M. Pharmacology of a new cyclic nucleotide phosphodiesterase type 4 inhibitor, V11294. Pulm Pharmacol Ther. 2003; 16(2):97-104. PMID: 12670778.
      Citations: 5     Fields:    Translation:HumansAnimals
    56. Halushka MK, Walker LP, Halushka PV, Halushka MK, Walker LP, Halushka PV. Genetic variation in cyclooxygenase 1: effects on response to aspirin. Clin Pharmacol Ther. 2003 Jan; 73(1):122-30. PMID: 12545150.
      Citations: 47     Fields:    Translation:HumansCells
    57. Malcolm R, Liao J, Michel M, Cochran K, Pye W, Yeager D, Halushka PV, Malcolm R, Liao J, Michel M, Cochran K, Pye W, Yeager D, Halushka PV. Amlodipine reduces blood pressure and headache frequency in cocaine-dependent outpatients. J Psychoactive Drugs. 2002 Oct-Dec; 34(4):415-9. PMID: 12562110.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    58. Halushka MK, Halushka PV, Halushka MK, Halushka PV. Why are some individuals resistant to the cardioprotective effects of aspirin? Could it be thromboxane A2? Circulation. 2002 Apr 09; 105(14):1620-2. PMID: 11940535.
      Citations: 15     Fields:    Translation:Cells
    59. Ferlito M, Romanenko OG, Guyton K, Ashton S, Squadrito F, Halushka PV, Cook JA, Ferlito M, Romanenko OG, Guyton K, Ashton S, Squadrito F, Halushka PV, Cook JA. Implication of Galpha i proteins and Src tyrosine kinases in endotoxin-induced signal transduction events and mediator production. J Endotoxin Res. 2002; 8(6):427-35. PMID: 12701623.
      Citations: 7     Fields:    Translation:HumansCells
    60. Ferlito M, Romanenko OG, Ashton S, Squadrito F, Halushka PV, Cook JA, Ferlito M, Romanenko OG, Ashton S, Squadrito F, Halushka PV, Cook JA. Effect of cross-tolerance between endotoxin and TNF-alpha or IL-1beta on cellular signaling and mediator production. J Leukoc Biol. 2001 Nov; 70(5):821-9. PMID: 11698503.
      Citations: 20     Fields:    Translation:Cells
    61. Tempel GE, Brown AN, Morinelli TA, Halushka PV, Cook JA, Tempel GE, Brown AN, Morinelli TA, Halushka PV, Cook JA. Changes in vascular responsiveness to a thromboxane mimetic in endotoxin tolerance. Shock. 2001 Nov; 16(5):389-92. PMID: 11699079.
      Citations:    Fields:    Translation:AnimalsCells
    62. Minshall RD, Pavcnik D, Halushka PV, Hermsmeyer K, Minshall RD, Pavcnik D, Halushka PV, Hermsmeyer K. Progesterone regulation of vascular thromboxane A(2) receptors in rhesus monkeys. Am J Physiol Heart Circ Physiol. 2001 Oct; 281(4):H1498-507. PMID: 11557538.
      Citations: 3     Fields:    Translation:AnimalsCells
    63. Guyton K, Bond R, Reilly C, Gilkeson G, Halushka P, Cook J, Guyton K, Bond R, Reilly C, Gilkeson G, Halushka P, Cook J. Differential effects of 15-deoxy-delta(12,14)-prostaglandin J2 and a peroxisome proliferator-activated receptor gamma agonist on macrophage activation. J Leukoc Biol. 2001 Apr; 69(4):631-8. PMID: 11310850.
      Citations: 9     Fields:    Translation:AnimalsCells
    64. Ferlito M, Squadrito F, Halushka PV, Cook JA, Ferlito M, Squadrito F, Halushka PV, Cook JA. Signal transduction events in Chinese hamster ovary cells expressing human CD14; effect of endotoxin desensitization. Shock. 2001 Apr; 15(4):291-6. PMID: 11303728.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    65. Reilly CM, Oates JC, Sudian J, Crosby MB, Halushka PV, Gilkeson GS, Reilly CM, Oates JC, Sudian J, Crosby MB, Halushka PV, Gilkeson GS. Prostaglandin J(2) inhibition of mesangial cell iNOS expression. Clin Immunol. 2001 Mar; 98(3):337-45. PMID: 11237557.
      Citations: 12     Fields:    Translation:AnimalsCells
    66. Walle T, Otake Y, Brubaker JA, Walle UK, Halushka PV, Walle T, Otake Y, Brubaker JA, Walle UK, Halushka PV. Disposition and metabolism of the flavonoid chrysin in normal volunteers. Br J Clin Pharmacol. 2001 Feb; 51(2):143-6. PMID: 11259985; PMCID: PMC2014445.
      Citations: 60     Fields:    Translation:HumansAnimalsCTClinical Trials
    67. Fernando LP, Fernando AN, Ferlito M, Halushka PV, Cook JA, Fernando LP, Fernando AN, Ferlito M, Halushka PV, Cook JA. Suppression of Cox-2 and TNF-alpha mRNA in endotoxin tolerance: effect of cycloheximide, antinomycin D, and okadaic acid. Shock. 2000 Aug; 14(2):128-33. PMID: 10947155.
      Citations: 7     Fields:    Translation:HumansCells
    68. Halushka PV, Halushka PV. Thromboxane A(2) receptors: where have you gone? Prostaglandins Other Lipid Mediat. 2000 Mar; 60(4-6):175-89. PMID: 10751648.
      Citations: 5     Fields:    Translation:HumansCells
    69. Reilly CM, Oates JC, Cook JA, Morrow JD, Halushka PV, Gilkeson GS, Reilly CM, Oates JC, Cook JA, Morrow JD, Halushka PV, Gilkeson GS. Inhibition of mesangial cell nitric oxide in MRL/lpr mice by prostaglandin J2 and proliferator activation receptor-gamma agonists. J Immunol. 2000 Feb 01; 164(3):1498-504. PMID: 10640767.
      Citations: 19     Fields:    Translation:AnimalsCells
    70. Becker KP, Garnovskaya M, Gettys T, Halushka PV, Becker KP, Garnovskaya M, Gettys T, Halushka PV. Coupling of thromboxane A2 receptor isoforms to Galpha13: effects on ligand binding and signalling. Biochim Biophys Acta. 1999 Jul 08; 1450(3):288-96. PMID: 10395940.
      Citations: 4     Fields:    Translation:AnimalsCells
    71. Fernando LP, Makhlouf M, Fernando AN, Ashton S, Halushka PV, Cook JA, Fernando LP, Makhlouf M, Fernando AN, Ashton S, Halushka PV, Cook JA. Tolerance to LPS decreases macrophage G protein content. Shock. 1999 May; 11(5):330-5. PMID: 10353538.
      Citations: 1     Fields:    Translation:AnimalsCells
    72. Pawate S, Schey KL, Meier GP, Ullian ME, Mais DE, Halushka PV, Pawate S, Schey KL, Meier GP, Ullian ME, Mais DE, Halushka PV. Expression, characterization, and purification of C-terminally hexahistidine-tagged thromboxane A2 receptors. J Biol Chem. 1998 Aug 28; 273(35):22753-60. PMID: 9712907.
      Citations: 5     Fields:    Translation:AnimalsCells
    73. Becker KP, Ullian M, Halushka PV, Becker KP, Ullian M, Halushka PV. Cloning and characterization of an endogenous COS-7 cell thromboxane A2 receptor. Biochim Biophys Acta. 1998 May 27; 1403(1):109-14. PMID: 9622606.
      Citations: 1     Fields:    Translation:AnimalsCells
    74. Durando M, Fernando L, Ashton S, Halushka P, Cook J, Durando M, Fernando L, Ashton S, Halushka P, Cook J. Suppressed thromboxane production in endotoxin-desensitized THP-1 cells is not a result of decreased prostaglandin H synthase activity. Shock. 1998 May; 9(5):359-63. PMID: 9617886.
      Citations:    Fields:    Translation:HumansCells
    75. Makhlouf MA, Fernando LP, Gettys TW, Halushka PV, Cook JA, Makhlouf MA, Fernando LP, Gettys TW, Halushka PV, Cook JA. Increased prostacyclin and PGE2 stimulated cAMP production by macrophages from endotoxin-tolerant rats. Am J Physiol. 1998 05; 274(5):C1238-44. PMID: 9612210.
      Citations:    Fields:    Translation:AnimalsCells
    76. Wang GR, Zhu Y, Halushka PV, Lincoln TM, Mendelsohn ME, Wang GR, Zhu Y, Halushka PV, Lincoln TM, Mendelsohn ME. Mechanism of platelet inhibition by nitric oxide: in vivo phosphorylation of thromboxane receptor by cyclic GMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1998 Apr 28; 95(9):4888-93. PMID: 9560198; PMCID: PMC20183.
      Citations: 76     Fields:    Translation:HumansCells
    77. Makhlouf M, Zingarelli B, Halushka PV, Cook JA, Makhlouf M, Zingarelli B, Halushka PV, Cook JA. Endotoxin tolerance alters macrophage membrane regulatory G proteins. Prog Clin Biol Res. 1998; 397:217-26. PMID: 9575562.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    78. Higashiura K, Mathur RS, Halushka PV, Higashiura K, Mathur RS, Halushka PV. Gender-related differences in androgen regulation of thromboxane A2 receptors in rat aortic smooth-muscle cells. J Cardiovasc Pharmacol. 1997 Mar; 29(3):311-5. PMID: 9125667.
      Citations: 13     Fields:    Translation:AnimalsCells
    79. Brothers TE, Robison JG, Elliott BM, Boggs JM, Halushka PV, Brothers TE, Robison JG, Elliott BM, Boggs JM, Halushka PV. Thromboxane A2 receptor density increases during chronic exposure to thromboxane A2 receptor antagonists after porcine carotid bypass. Cardiovasc Surg. 1997 Feb; 5(1):92-8. PMID: 9158129.
      Citations: 2     Fields:    Translation:Animals
    80. Schrör K, Davis-Bruno K, Halushka PV, Schr?r K, Davis-Bruno K, Halushka PV. Modification on ligand binding to TXA2/PGH2 receptors by diethylpyrocarbonate. Adv Exp Med Biol. 1997; 400A:235-40. PMID: 9547563.
      Citations:    Fields:    Translation:HumansCells
    81. Higashiura K, Blaney B, Morgan E, Mathur RS, Halushka PV, Higashiura K, Blaney B, Morgan E, Mathur RS, Halushka PV. Inhibition of testosterone 5 alpha-reductase: evidence for tissue-specific regulation of thromboxane A2 receptors. J Pharmacol Exp Ther. 1996 Dec; 279(3):1386-91. PMID: 8968363.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    82. Makhlouf M, Ashton SH, Hildebrandt J, Mehta N, Gettys TW, Halushka PV, Cook JA, Makhlouf M, Ashton SH, Hildebrandt J, Mehta N, Gettys TW, Halushka PV, Cook JA. Alterations in macrophage G proteins are associated with endotoxin tolerance. Biochim Biophys Acta. 1996 Jun 13; 1312(2):163-8. PMID: 8672540.
      Citations: 3     Fields:    Translation:AnimalsCells
    83. Allan CJ, Higashiura K, Martin M, Morinelli TA, Kurtz DT, Geoffroy O, Meier GP, Gettys TW, Halushka PV, Allan CJ, Higashiura K, Martin M, Morinelli TA, Kurtz DT, Geoffroy O, Meier GP, Gettys TW, Halushka PV. Characterization of the cloned HEL cell thromboxane A2 receptor: evidence that the affinity state can be altered by G alpha 13 and G alpha q. J Pharmacol Exp Ther. 1996 May; 277(2):1132-9. PMID: 8627525.
      Citations: 2     Fields:    Translation:HumansCells
    84. Zucker TP, Higashiura K, Mathur RS, Halushka PV, Zucker TP, Higashiura K, Mathur RS, Halushka PV. Androstenedione increases thromboxane A2 receptors in human erythroleukemia cells. Life Sci. 1996; 58(8):683-90. PMID: 8594318.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    85. Paul RV, Saxenhofer H, Wackym PS, Halushka PV, Paul RV, Saxenhofer H, Wackym PS, Halushka PV. Stimulation of rat mesangial cell thromboxane A2 receptors inhibits particulate but not soluble guanylyl cyclase. Am J Physiol. 1996 Jan; 270(1 Pt 2):F31-8. PMID: 8769820.
      Citations:    Fields:    Translation:AnimalsCells
    86. Wagner RS, Halushka PV, Cook JA, Wagner RS, Halushka PV, Cook JA. Activation of thromboxane A2 receptors alters lipopolysaccharide-induced adherence of THP-1 cells. Shock. 1996 Jan; 5(1):41-6. PMID: 8821102.
      Citations:    Fields:    Translation:HumansCells
    87. Halushka PV, Allan CJ, Davis-Bruno KL, Halushka PV, Allan CJ, Davis-Bruno KL. Thromboxane A2 receptors. J Lipid Mediat Cell Signal. 1995 Oct; 12(2-3):361-78. PMID: 8777579.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    88. Ajayi AA, Mathur R, Halushka PV, Ajayi AA, Mathur R, Halushka PV. Testosterone increases human platelet thromboxane A2 receptor density and aggregation responses. Circulation. 1995 Jun 01; 91(11):2742-7. PMID: 7758179.
      Citations: 72     Fields:    Translation:HumansCellsCTClinical Trials
    89. Schrör K, Davis-Bruno K, Halushka PV, Schr?r K, Davis-Bruno K, Halushka PV. Inhibition of ligand binding to thromboxane A2/prostaglandin H2 receptors by diethylpyrocarbonate. Protection by receptor ligands and reversal by hydroxylamine. Biochem Pharmacol. 1995 Mar 30; 49(7):921-7. PMID: 7741764.
      Citations: 1     Fields:    Translation:HumansCells
    90. Matsuda K, Mathur RS, Ullian ME, Halushka PV, Matsuda K, Mathur RS, Ullian ME, Halushka PV. Sex steroid regulation of thromboxane A2 receptors in cultured rat aortic smooth muscle cells. Prostaglandins. 1995 Mar; 49(3):183-96. PMID: 7652187.
      Citations: 2     Fields:    Translation:AnimalsCells
    91. Zingarelli B, Halushka PV, Caputi AP, Cook JA, Zingarelli B, Halushka PV, Caputi AP, Cook JA. Increased nitric oxide synthesis during the development of endotoxin tolerance. Shock. 1995 Feb; 3(2):102-8. PMID: 7749936.
      Citations: 12     Fields:    Translation:AnimalsCells
    92. Halushka PV, Matsuda K, Masuda A, Ruff A, Morinelli TA, Mathur RS, Halushka PV, Matsuda K, Masuda A, Ruff A, Morinelli TA, Mathur RS. Testosterone regulation of platelet and vascular thromboxane A2 receptors. Agents Actions Suppl. 1995; 45:19-26. PMID: 7717179.
      Citations: 1     Fields:    Translation:AnimalsCells
    93. Ajayi AA, Matsuda K, Schrör K, Masuda A, Mathur R, Halushka PV, Ajayi AA, Matsuda K, Schr?r K, Masuda A, Mathur R, Halushka PV. Androgen regulation of thromboxane A2 receptors. Adv Prostaglandin Thromboxane Leukot Res. 1995; 23:251-3. PMID: 7732846.
      Citations:    Fields:    Translation:HumansAnimalsCells
    94. Zingarelli B, Chen H, Caputi AP, Halushka PV, Cook JA, Zingarelli B, Chen H, Caputi AP, Halushka PV, Cook JA. Reorientation of macrophage mediator production in endotoxin tolerance. Prog Clin Biol Res. 1995; 392:529-37. PMID: 8524961.
      Citations: 2     Fields:    Translation:AnimalsCells
    95. Zucker TP, Grosser T, Morinelli T, Halushka PV, Sachinidis A, Vetter H, Schrör K, Zucker TP, Grosser T, Morinelli T, Halushka PV, Sachinidis A, Vetter H, Schr?r K. Potentiation of PDGF-induced growth responses in coronary artery smooth muscle cells by thromboxane. Agents Actions Suppl. 1995; 45:53-8. PMID: 7717201.
      Citations: 3     Fields:    Translation:AnimalsCells
    96. Geisel J, Cook JA, Ashton SH, Wise WC, Halushka PV, Geisel J, Cook JA, Ashton SH, Wise WC, Halushka PV. Endotoxin tolerance is associated with decreased prostaglandin H synthases-1 and -2. Am J Physiol. 1994 Oct; 267(4 Pt 1):C1067-72. PMID: 7943269.
      Citations: 1     Fields:    Translation:AnimalsCells
    97. Matsuda K, Ruff A, Morinelli TA, Mathur RS, Halushka PV, Matsuda K, Ruff A, Morinelli TA, Mathur RS, Halushka PV. Testosterone increases thromboxane A2 receptor density and responsiveness in rat aortas and platelets. Am J Physiol. 1994 Sep; 267(3 Pt 2):H887-93. PMID: 8092292.
      Citations: 20     Fields:    Translation:AnimalsCells
    98. Yin K, Halushka PV, Yan YT, Wong PY, Yin K, Halushka PV, Yan YT, Wong PY. Antiaggregatory activity of 8-epi-prostaglandin F2 alpha and other F-series prostanoids and their binding to thromboxane A2/prostaglandin H2 receptors in human platelets. J Pharmacol Exp Ther. 1994 Sep; 270(3):1192-6. PMID: 7932171.
      Citations: 13     Fields:    Translation:HumansCells
    99. Allan CJ, Halushka PV, Allan CJ, Halushka PV. Characterization of human peripheral blood monocyte thromboxane A2 receptors. J Pharmacol Exp Ther. 1994 Aug; 270(2):446-52. PMID: 8071836.
      Citations: 4     Fields:    Translation:HumansCells
    100. Buzzard CJ, Pfister SL, Halushka PV, Campbell WB, Buzzard CJ, Pfister SL, Halushka PV, Campbell WB. Decrease in vascular TxA2 receptors in a subgroup of rabbits unresponsive to a TxA2 mimetic. Am J Physiol. 1994 Jun; 266(6 Pt 2):H2320-6. PMID: 8023992.
      Citations: 2     Fields:    Translation:Animals
    101. Chen H, Halushka PV, Cook JA, Chen H, Halushka PV, Cook JA. Endotoxin tolerance: effects on lethality and macrophage thromboxane (B2) and interleukin 6 production. Shock. 1994 May; 1(5):366-71. PMID: 7743340.
      Citations:    Fields:    Translation:AnimalsCells
    102. Okwu AK, Mais DE, Halushka PV, Okwu AK, Mais DE, Halushka PV. Agonist-induced phosphorylation of human platelet TXA2/PGH2 receptors. Biochim Biophys Acta. 1994 Mar 10; 1221(1):83-8. PMID: 8130280.
      Citations: 1     Fields:    Translation:HumansCells
    103. Schrör K, Morinelli TA, Masuda A, Matsuda K, Mathur RS, Halushka PV, Schr?r K, Morinelli TA, Masuda A, Matsuda K, Mathur RS, Halushka PV. Testosterone treatment enhances thromboxane A2 mimetic induced coronary artery vasoconstriction in guinea pigs. Eur J Clin Invest. 1994 Feb; 24 Suppl 1:50-2. PMID: 8013532.
      Citations: 17     Fields:    Translation:Animals
    104. Halushka PV, Masuda A, Matsuda K, Halushka PV, Masuda A, Matsuda K. The Gordon Wilson Lecture. Regulation of thromboxane A2 receptors by testosterone: implications for steroid abuse and cardiovascular disease. Trans Am Clin Climatol Assoc. 1994; 105:95-103. PMID: 7974982; PMCID: PMC2376721.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    105. Rinder CA, Halushka PV, Sens MA, Ploth DW, Rinder CA, Halushka PV, Sens MA, Ploth DW. Thromboxane A2 receptor blockade improves renal function and histopathology in the post-obstructive kidney. Kidney Int. 1994 Jan; 45(1):185-92. PMID: 8127008.
      Citations: 3     Fields:    Translation:Animals
    106. Matsuda K, Mathur RS, Duzic E, Halushka PV, Matsuda K, Mathur RS, Duzic E, Halushka PV. Androgen regulation of thromboxane A2/prostaglandin H2 receptor expression in human erythroleukemia cells. Am J Physiol. 1993 Dec; 265(6 Pt 1):E928-34. PMID: 8279549.
      Citations: 4     Fields:    Translation:HumansCells
    107. Morinelli TA, Tempel GE, Jaffa AA, Silva RH, Naka M, Folger W, Halushka PV, Morinelli TA, Tempel GE, Jaffa AA, Silva RH, Naka M, Folger W, Halushka PV. Thromboxane A2/prostaglandin H2 receptors in streptozotocin-induced diabetes: effects of insulin therapy in the rat. Prostaglandins. 1993 May; 45(5):427-38. PMID: 8321912.
      Citations: 2     Fields:    Translation:AnimalsCells
    108. Liel N, Nathan I, Yermiyahu T, Zolotov Z, Lieberman JR, Dvilansky A, Halushka PV, Liel N, Nathan I, Yermiyahu T, Zolotov Z, Lieberman JR, Dvilansky A, Halushka PV. Increased platelet thromboxane A2/prostaglandin H2 receptors in patients with pregnancy induced hypertension. Thromb Res. 1993 May 01; 70(3):205-10. PMID: 8327985.
      Citations: 2     Fields:    Translation:HumansCells
    109. Matera G, Cook JA, Geisel J, Ashton SH, Wise WC, Focá A, Berkowitz BA, Halushka PV, Matera G, Cook JA, Geisel J, Ashton SH, Wise WC, Foc? A, Berkowitz BA, Halushka PV. Effects of two magainin peptides on eicosanoid release from rat peritoneal macrophages. Antimicrob Agents Chemother. 1993 Mar; 37(3):393-7. PMID: 8460910; PMCID: PMC187682.
      Citations: 2     Fields:    Translation:AnimalsCells
    110. Orr RK, Hoehn JL, Col NF, Cook JA, Geisel J, Halushka PV, Reines HD. Prostaglandins, thromboxanes, leukotrienes, and cytochrome P-450 metabolites of arachidonic acid. New Horiz. 1993 Feb; 1(1):60-9. PMID: 7922394.
      Citations: 1     Fields:    Translation:HumansAnimals
    111. Simmons TR, Cook JA, Moore JN, Halushka PV, Simmons TR, Cook JA, Moore JN, Halushka PV. Thromboxane A2 receptors in equine monocytes: identification of a new subclass of TXA2 receptors. J Leukoc Biol. 1993 Feb; 53(2):173-8. PMID: 8383167.
      Citations: 2     Fields:    Translation:AnimalsCells
    112. Folger WH, Halushka PV, Wilcox CS, Guzman NJ, Folger WH, Halushka PV, Wilcox CS, Guzman NJ. Characterization of rat glomerular thromboxane A2 receptors: comparison to rat platelets. Eur J Pharmacol. 1992 Sep 01; 227(1):71-8. PMID: 1426024.
      Citations: 3     Fields:    Translation:AnimalsCells
    113. Coffee KA, Halushka PV, Ashton SH, Tempel GE, Wise WC, Cook JA, Coffee KA, Halushka PV, Ashton SH, Tempel GE, Wise WC, Cook JA. Endotoxin tolerance is associated with altered GTP-binding protein function. J Appl Physiol (1985). 1992 Sep; 73(3):1008-13. PMID: 1400011.
      Citations: 5     Fields:    Translation:AnimalsCells
    114. Naka M, Mais DE, Morinelli TA, Hamanaka N, Oatis JE, Halushka PV, Naka M, Mais DE, Morinelli TA, Hamanaka N, Oatis JE, Halushka PV. 7-[(1R,2S,3S,5R)-6,6-dimethyl-3-(4- iodobenzenesulfonylamino)bicyclo[3.1.1]hept-2-yl]-5(Z)-heptenoic acid: a novel high-affinity radiolabeled antagonist for platelet thromboxane A2/prostaglandin H2 receptors. J Pharmacol Exp Ther. 1992 Aug; 262(2):632-7. PMID: 1386885.
      Citations: 3     Fields:    Translation:HumansCells
    115. Okwu AK, Ullian ME, Halushka PV, Okwu AK, Ullian ME, Halushka PV. Homologous desensitization of human platelet thromboxane A2/prostaglandin H2 receptors. J Pharmacol Exp Ther. 1992 Jul; 262(1):238-45. PMID: 1378092.
      Citations: 5     Fields:    Translation:HumansCells
    116. Bernard GR, Reines HD, Halushka PV, Higgins SB, Metz CA, Swindell BB, Wright PE, Watts FL, Vrbanac JJ, Bernard GR, Reines HD, Halushka PV, Higgins SB, Metz CA, Swindell BB, Wright PE, Watts FL, Vrbanac JJ. Prostacyclin and thromboxane A2 formation is increased in human sepsis syndrome. Effects of cyclooxygenase inhibition. Am Rev Respir Dis. 1991 Nov; 144(5):1095-101. PMID: 1952438.
      Citations: 18     Fields:    Translation:HumansCTClinical Trials
    117. Masuda A, Mathur R, Halushka PV, Masuda A, Mathur R, Halushka PV. Testosterone increases thromboxane A2 receptors in cultured rat aortic smooth muscle cells. Circ Res. 1991 Sep; 69(3):638-43. PMID: 1831411.
      Citations: 12     Fields:    Translation:AnimalsCells
    118. Geisel J, Cook JA, Coffee KA, Wise WC, Halushka PV, Geisel J, Cook JA, Coffee KA, Wise WC, Halushka PV. Endotoxin-induced arachidonic acid metabolism requires de novo protein synthesis and protein kinase C activation. Biochim Biophys Acta. 1991 Aug 20; 1085(1):15-20. PMID: 1909897.
      Citations: 5     Fields:    Translation:AnimalsCells
    119. Li EJ, Cook JA, Wise WC, Jackson WT, Halushka PV, Li EJ, Cook JA, Wise WC, Jackson WT, Halushka PV. Effect of LTB4 receptor antagonists in endotoxic shock in the rat. Circ Shock. 1991 Aug; 34(4):385-92. PMID: 1663429.
      Citations: 1     Fields:    Translation:Animals
    120. Mayeux PR, Morinelli TA, Williams TC, Hazard ES, Mais DE, Oatis JE, Baron DA, Halushka PV, Mayeux PR, Morinelli TA, Williams TC, Hazard ES, Mais DE, Oatis JE, Baron DA, Halushka PV. Differential effect of pH on thromboxane A2/prostaglandin H2 receptor agonist and antagonist binding in human platelets. J Biol Chem. 1991 Jul 25; 266(21):13752-8. PMID: 1830308.
      Citations: 3     Fields:    Translation:HumansCells
    121. Masuda A, Mais DE, Oatis JE, Halushka PV, Masuda A, Mais DE, Oatis JE, Halushka PV. Platelet and vascular thromboxane A2/prostaglandin H2 receptors. Evidence for different subclasses in the rat. Biochem Pharmacol. 1991 Jul 15; 42(3):537-44. PMID: 1830482.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    122. Li EJ, Cook JA, Ashton S, Wise WC, Halushka PV, Li EJ, Cook JA, Ashton S, Wise WC, Halushka PV. Effect of the LTD4 receptor antagonist LY203647 on endotoxic shock sequelae in the rat. Eur J Pharmacol. 1991 Jun 25; 199(2):221-5. PMID: 1954979.
      Citations:    Fields:    Translation:AnimalsCells
    123. Morinelli TA, Halushka PV, Morinelli TA, Halushka PV. Thromboxane-A(2)/prostaglandin-H(2) receptors Characterization and antagonism. Trends Cardiovasc Med. 1991 May-Jun; 1(4):157-61. PMID: 21239318.
      Citations:    
    124. Mais DE, Bowling NL, True TA, Naka M, Morinelli TA, Oatis JE, Hamanaka N, Halushka PV, Mais DE, Bowling NL, True TA, Naka M, Morinelli TA, Oatis JE, Hamanaka N, Halushka PV. Novel synthesis and biochemical properties of an [125I]-labeled photoaffinity probe for thromboxane A2/prostaglandin H2 receptors. J Med Chem. 1991 Apr; 34(4):1511-4. PMID: 1826745.
      Citations:    Fields:    Translation:HumansCells
    125. Mayeux PR, Mais DE, Halushka PV, Mayeux PR, Mais DE, Halushka PV. Interactions of dihydropyridine Ca2+ channel agonists with the human platelet thromboxane A2/prostaglandin H2 receptor. Eur J Pharmacol. 1991 Jan 25; 206(1):15-21. PMID: 1712307.
      Citations: 1     Fields:    Translation:HumansCells
    126. Morinelli TA, Naka M, Masuda A, Oatis JE, Okwu AK, Mais DE, Saussy DL, Halushka PV, Morinelli TA, Naka M, Masuda A, Oatis JE, Okwu AK, Mais DE, Saussy DL, Halushka PV. Characterization of thromboxane A2/prostaglandin H2 receptors of various tissues using a new radioiodinated thromboxane A2/prostaglandin H2 mimetic, I-BOP. Adv Prostaglandin Thromboxane Leukot Res. 1991; 21A:331-7. PMID: 1825565.
      Citations: 2     Fields:    Translation:AnimalsCells
    127. Zellner JL, Cook JA, Reines HD, Smith EF, Kessler LD, Halushka PV, Zellner JL, Cook JA, Reines HD, Smith EF, Kessler LD, Halushka PV. Effect of a LTD4 receptor antagonist in porcine septic shock. Eicosanoids. 1991; 4(3):169-75. PMID: 1663380.
      Citations: 2     Fields:    Translation:AnimalsCells
    128. Coffee KA, Halushka PV, Wise WC, Tempel GE, Cook JA, Coffee KA, Halushka PV, Wise WC, Tempel GE, Cook JA. Endotoxin tolerance differentially alters hemodynamic responses to a thromboxane A2 mimetic and phenylephrine. J Cardiovasc Pharmacol. 1991 Jan; 17(1):20-6. PMID: 1708052.
      Citations: 2     Fields:    Translation:Animals
    129. Moore JN, Cook JA, Henry MM, Jonsson HT, Spicer KM, Wise WC, Halushka PV, Moore JN, Cook JA, Henry MM, Jonsson HT, Spicer KM, Wise WC, Halushka PV. Effects of a linseed oil enriched diet on endotoxin-induced sequelae: differential in vitro and in vivo effects. Eicosanoids. 1991; 4(1):47-55. PMID: 2059458.
      Citations:    Fields:    Translation:AnimalsCells
    130. Masuda A, Halushka PV, Masuda A, Halushka PV. Thromboxane A2 receptors are influenced by cell density in cultured rat aortic smooth muscle cells. Life Sci. 1991; 48(25):2391-5. PMID: 1828517.
      Citations:    Fields:    Translation:AnimalsCells
    131. Sessa WC, Halushka PV, Okwu A, Nasjletti A, Sessa WC, Halushka PV, Okwu A, Nasjletti A. Characterization of the vascular thromboxane A2/prostaglandin endoperoxide receptor in rabbit aorta. Regulation by dexamethasone. Circ Res. 1990 Dec; 67(6):1562-9. PMID: 2147131.
      Citations: 4     Fields:    Translation:AnimalsCells
    132. Cook JA, Li EJ, Spicer KM, Wise WC, Halushka PV, Cook JA, Li EJ, Spicer KM, Wise WC, Halushka PV. Effect of leukotriene receptor antagonists on vascular permeability during endotoxic shock. Circ Shock. 1990 Nov; 32(3):209-18. PMID: 2175680.
      Citations: 2     Fields:    Translation:AnimalsCells
    133. Mais DE, Liel N, Halushka PV, Mais DE, Liel N, Halushka PV. Photoaffinity receptor antagonist for human platelet thromboxane A2/prostaglandin H2 receptors. Biochem Pharmacol. 1990 Oct 01; 40(7):1457-61. PMID: 2145838.
      Citations:    Fields:    Translation:HumansCells
    134. Coffee KA, Halushka PV, Wise WC, Cook JA, Coffee KA, Halushka PV, Wise WC, Cook JA. Altered responses to modulators of guanine nucleotide binding protein activity in endotoxin tolerance. Biochim Biophys Acta. 1990 Aug 17; 1035(2):201-5. PMID: 2118385.
      Citations: 1     Fields:    Translation:AnimalsCells
    135. Moore JN, Cook JA, Morris DD, Halushka PV, Wise WC, Moore JN, Cook JA, Morris DD, Halushka PV, Wise WC. Endotoxin-induced procoagulant activity, eicosanoid synthesis, and tumor necrosis factor production by rat peritoneal macrophages: effect of endotoxin tolerance and glucan. Circ Shock. 1990 Jul; 31(3):281-95. PMID: 2113440.
      Citations: 5     Fields:    Translation:AnimalsCells
    136. Li EJ, Cook JA, Spicer KM, Wise WC, Rokach J, Halushka PV, Li EJ, Cook JA, Spicer KM, Wise WC, Rokach J, Halushka PV. Resistance of essential fatty acid-deficient rats to endotoxin-induced increases in vascular permeability. Circ Shock. 1990 Jun; 31(2):159-70. PMID: 2188748.
      Citations:    Fields:    Translation:AnimalsCells
    137. Nishimiya T, Daniell HB, Webb JG, Oatis J, Walle T, Gaffney TE, Halushka PV, Nishimiya T, Daniell HB, Webb JG, Oatis J, Walle T, Gaffney TE, Halushka PV. Chronic treatment with propranolol enhances the synthesis of prostaglandins E2 and I2 by the aorta of spontaneously hypertensive rats. J Pharmacol Exp Ther. 1990 Apr; 253(1):207-13. PMID: 2109798.
      Citations: 2     Fields:    Translation:Animals
    138. Halushka PV, Morinelli TA, Mais DE, Halushka PV, Morinelli TA, Mais DE. Radioligand binding assays for thromboxane A2/prostaglandin H2 receptors. Methods Enzymol. 1990; 187:397-405. PMID: 2146462.
      Citations:    Fields:    Translation:HumansAnimalsCells
    139. Morinelli TA, Mais DE, Oatis JE, Crumbley AJ, Halushka PV, Morinelli TA, Mais DE, Oatis JE, Crumbley AJ, Halushka PV. Characterization of thromboxane A2/prostaglandin H2 receptors in human vascular smooth muscle cells. Life Sci. 1990; 46(24):1765-72. PMID: 2141663.
      Citations: 3     Fields:    Translation:HumansCells
    140. Morinelli TA, Mais DE, Oatis JE, Mayeux PR, Okwu AK, Masuda A, Knapp DR, Halushka PV, Morinelli TA, Mais DE, Oatis JE, Mayeux PR, Okwu AK, Masuda A, Knapp DR, Halushka PV. I-BOP, the most potent radiolabelled agonist for the TXA2/PGH2 receptor. Adv Prostaglandin Thromboxane Leukot Res. 1990; 20:102-9. PMID: 2144685.
      Citations:    Fields:    Translation:HumansCells
    141. Zellner JL, Cook JA, Reines DH, Wise WC, Smith EF, Kessler LD, Halushka PV, Zellner JL, Cook JA, Reines DH, Wise WC, Smith EF, Kessler LD, Halushka PV. Hemodynamic effects of leukotriene (LT) D4 and a LTD4 receptor antagonist in the pig. Eicosanoids. 1990; 3(4):219-24. PMID: 1963540.
      Citations:    Fields:    Translation:Animals
    142. Dorn GW, Liel N, Trask JL, Mais DE, Assey ME, Halushka PV, Dorn GW, Liel N, Trask JL, Mais DE, Assey ME, Halushka PV. Increased platelet thromboxane A2/prostaglandin H2 receptors in patients with acute myocardial infarction. Circulation. 1990 Jan; 81(1):212-8. PMID: 2137044.
      Citations: 10     Fields:    Translation:HumansCells
    143. Morinelli TA, Oatis JE, Okwu AK, Mais DE, Mayeux PR, Masuda A, Knapp DR, Halushka PV, Morinelli TA, Oatis JE, Okwu AK, Mais DE, Mayeux PR, Masuda A, Knapp DR, Halushka PV. Characterization of an 125I-labeled thromboxane A2/prostaglandin H2 receptor agonist. J Pharmacol Exp Ther. 1989 Nov; 251(2):557-62. PMID: 2530338.
      Citations: 12     Fields:    Translation:Humans
    144. Heffner JE, Cook JA, Halushka PV, Heffner JE, Cook JA, Halushka PV. Human platelets modulate edema formation in isolated rabbit lungs. J Clin Invest. 1989 Sep; 84(3):757-64. PMID: 2527253; PMCID: PMC329716.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    145. Mayeux PR, Mais DE, Carr C, Halushka PV, Mayeux PR, Mais DE, Carr C, Halushka PV. Human erythroleukemia cells express functional thromboxane A2/prostaglandin H2 receptors. J Pharmacol Exp Ther. 1989 Sep; 250(3):923-7. PMID: 2528631.
      Citations: 4     Fields:    Translation:HumansCells
    146. Ball HA, Cook JA, Spicer KM, Wise WC, Halushka PV, Ball HA, Cook JA, Spicer KM, Wise WC, Halushka PV. Essential fatty acid-deficient rats are resistant to oleic acid-induced pulmonary injury. J Appl Physiol (1985). 1989 Aug; 67(2):811-6. PMID: 2551875.
      Citations: 1     Fields:    Translation:Animals
    147. Mais DE, Yoakim C, Guindon Y, Gillard JW, Rokach J, Halushka PV, Mais DE, Yoakim C, Guindon Y, Gillard JW, Rokach J, Halushka PV. Photoaffinity labelling of the human platelet thromboxane A2/prostaglandin H2 receptor. Biochim Biophys Acta. 1989 Jul 11; 1012(2):184-90. PMID: 2525928.
      Citations: 2     Fields:    Translation:HumansCells
    148. Orr RK, Hoehn JL, Col NF, Lee WM, Reines D, Watt GH, Cook JA, Wise WC, Halushka PV, Galbraith RM. Alterations in Gc levels and complexing in septic shock. Circ Shock. 1989 Jul; 28(3):249-55. PMID: 2766479.
      Citations: 3     Fields:    Translation:Humans
    149. Watt GH, Ashton SH, Cook JA, Wise WC, Halushka PV, Galbraith RM, Watt GH, Ashton SH, Cook JA, Wise WC, Halushka PV, Galbraith RM. Alterations in plasma levels and complexing of Gc (vitamin D-binding protein) in rats with endotoxic shock. Circ Shock. 1989 Jul; 28(3):279-91. PMID: 2766482.
      Citations: 4     Fields:    Translation:Animals
    150. Morinelli TA, Okwu AK, Mais DE, Halushka PV, John V, Chen CK, Fried J, Morinelli TA, Okwu AK, Mais DE, Halushka PV, John V, Chen CK, Fried J. Difluorothromboxane A2 and stereoisomers: stable derivatives of thromboxane A2 with differential effects on platelets and blood vessels. Proc Natl Acad Sci U S A. 1989 Jul; 86(14):5600-4. PMID: 2748606; PMCID: PMC297670.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    151. Powers K, Fyfe DA, Taylor AB, Halushka PV, Crawford FA, Powers K, Fyfe DA, Taylor AB, Halushka PV, Crawford FA. Treatment of pulmonary vasospasm with prazosin after atrial septal defect closure in a child. J Thorac Cardiovasc Surg. 1989 May; 97(5):802-4. PMID: 2709872.
      Citations:    Fields:    Translation:Humans
    152. Rogers TS, Halushka PV, Wise WC, Cook JA, Rogers TS, Halushka PV, Wise WC, Cook JA. Arachidonic acid turnover in peritoneal macrophages is altered in endotoxin-tolerant rats. Biochim Biophys Acta. 1989 Feb 06; 1001(2):169-75. PMID: 2492824.
      Citations:    Fields:    Translation:AnimalsCells
    153. Tempel GE, Strong JW, Wise WC, Cook JA, Smith EF, Halushka PV, Tempel GE, Strong JW, Wise WC, Cook JA, Smith EF, Halushka PV. The role of eicosanoids in mediating blood flow alterations in endotoxin shock. Prog Clin Biol Res. 1989; 299:33-42. PMID: 2498907.
      Citations:    Fields:    Translation:HumansAnimals
    154. Wise WC, Cook JA, Tempel GE, Reines HD, Halushka PV, Wise WC, Cook JA, Tempel GE, Reines HD, Halushka PV. The rat in sepsis and endotoxic shock. Prog Clin Biol Res. 1989; 299:243-52. PMID: 2657793.
      Citations:    Fields:    Translation:HumansAnimals
    155. Halushka PV, Mais DE, Morinelli TA, Halushka PV, Mais DE, Morinelli TA. Thromboxane and prostacyclin receptors. Prog Clin Biol Res. 1989; 301:21-8. PMID: 2529548.
      Citations:    Fields:    Translation:HumansAnimalsCells
    156. Halushka PV, Mais DE, Mayeux PR, Morinelli TA, Halushka PV, Mais DE, Mayeux PR, Morinelli TA. Thromboxane, prostaglandin and leukotriene receptors. Annu Rev Pharmacol Toxicol. 1989; 29:213-39. PMID: 2543270.
      Citations: 33     Fields:    Translation:HumansAnimals
    157. Halushka PV, Halushka PV. Pharmacology of thromboxane A2 receptor antagonists. Z Kardiol. 1989; 78 Suppl 3:42-7. PMID: 2530712.
      Citations:    Fields:    Translation:HumansAnimals
    158. Mais DE, Halushka PV, Mais DE, Halushka PV. Photoaffinity labelling and isoelectric focusing of the human platelet thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor. Adv Prostaglandin Thromboxane Leukot Res. 1989; 19:168-71. PMID: 2526465.
      Citations:    Fields:    Translation:HumansCells
    159. Mais DE, Halushka PV, Mais DE, Halushka PV. Photoaffinity labelling of the human platelet thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor. Prog Clin Biol Res. 1989; 301:303-7. PMID: 2529550.
      Citations:    Fields:    Translation:HumansCells
    160. Mayeux PR, Morton HE, Gillard J, Lord A, Morinelli TA, Boehm A, Mais DE, Halushka PV, Mayeux PR, Morton HE, Gillard J, Lord A, Morinelli TA, Boehm A, Mais DE, Halushka PV. The affinities of prostaglandin H2 and thromboxane A2 for their receptor are similar in washed human platelets. Biochem Biophys Res Commun. 1988 Dec 15; 157(2):733-9. PMID: 2974286.
      Citations: 8     Fields:    Translation:HumansCells
    161. Liel N, Mais DE, Halushka PV, Liel N, Mais DE, Halushka PV. Desensitization of platelet thromboxane A2/prostaglandin H2 receptors by the mimetic U46619. J Pharmacol Exp Ther. 1988 Dec; 247(3):1133-8. PMID: 2974487.
      Citations: 5     Fields:    Translation:HumansCells
    162. Matera G, Cook JA, Hennigar RA, Tempel GE, Wise WC, Oglesby TD, Halushka PV, Matera G, Cook JA, Hennigar RA, Tempel GE, Wise WC, Oglesby TD, Halushka PV. Beneficial effects of a 5-lipoxygenase inhibitor in endotoxic shock in the rat. J Pharmacol Exp Ther. 1988 Oct; 247(1):363-71. PMID: 3171981.
      Citations: 8     Fields:    Translation:Animals
    163. Katz SA, Venkatachalam M, Crouch RK, Heffner JE, Halushka PV, Wise WC, Cook JA, Katz SA, Venkatachalam M, Crouch RK, Heffner JE, Halushka PV, Wise WC, Cook JA. Catalase pretreatment attenuates oleic acid-induced edema in isolated rabbit lung. J Appl Physiol (1985). 1988 Sep; 65(3):1301-6. PMID: 3182500.
      Citations: 4     Fields:    Translation:Animals
    164. Ball HA, Cook JA, Spicer KM, Hsu CY, Halushka PV, Ball HA, Cook JA, Spicer KM, Hsu CY, Halushka PV. Oleic acid-induced pulmonary injury in rats: potential role of sulfidopeptide leukotrienes. Circ Shock. 1988 Sep; 26(1):59-70. PMID: 2847882.
      Citations:    Fields:    Translation:Animals
    165. Heffner JE, Katz SA, Halushka PV, Cook JA, Heffner JE, Katz SA, Halushka PV, Cook JA. Human platelets attenuate oxidant injury in isolated rabbit lungs. J Appl Physiol (1985). 1988 Sep; 65(3):1258-66. PMID: 3182495.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    166. Mais DE, DeHoll D, Sightler H, Halushka PV, Mais DE, DeHoll D, Sightler H, Halushka PV. Different pharmacologic activities for 13-azapinane thromboxane A2 analogs in platelets and blood vessels. Eur J Pharmacol. 1988 Apr 13; 148(3):309-15. PMID: 2968271.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    167. Saussy DL, Mais DE, Baron DA, Pepkowitz SH, Halushka PV, Saussy DL, Mais DE, Baron DA, Pepkowitz SH, Halushka PV. Subcellular localization of a thromboxane A2/prostaglandin H2 receptor antagonist binding site in human platelets. Biochem Pharmacol. 1988 Feb 15; 37(4):647-54. PMID: 2963640.
      Citations: 1     Fields:    Translation:HumansCells
    168. Orr RK, Hoehn JL, Col NF, Halushka PV, Boehm A, Mais DE. Polymyxin B increases TXA2/PGH2 agonist and antagonist affinities in human platelet membranes. Eicosanoids. 1988; 1(1):41-4. PMID: 2856171.
      Citations:    Fields:    Translation:HumansCells
    169. Hsu CY, Halushka PV, Spicer KM, Hogan EL, Martin HF, Hsu CY, Halushka PV, Spicer KM, Hogan EL, Martin HF. Temporal profile of thromboxane-prostacyclin imbalance in experimental spinal cord injury. J Neurol Sci. 1988 Jan; 83(1):55-62. PMID: 3346710.
      Citations: 4     Fields:    Translation:Animals
    170. Dorn GW, Burch RM, Kochel PJ, Mais DE, Halushka PV, Dorn GW, Burch RM, Kochel PJ, Mais DE, Halushka PV. Decrease in agonist affinity for human platelet thromboxane A2/prostaglandin H2 receptors induced by a platelet-derived supernatant. Biochem Pharmacol. 1987 Jun 15; 36(12):1913-7. PMID: 2954555.
      Citations: 2     Fields:    Translation:HumansCells
    171. Dorn GW, Sens D, Chaikhouni A, Mais D, Halushka PV, Dorn GW, Sens D, Chaikhouni A, Mais D, Halushka PV. Cultured human vascular smooth muscle cells with functional thromboxane A2 receptors: measurement of U46619-induced 45calcium efflux. Circ Res. 1987 Jun; 60(6):952-6. PMID: 2954721.
      Citations: 5     Fields:    Translation:HumansCells
    172. Liel N, Mais DE, Halushka PV, Liel N, Mais DE, Halushka PV. Binding of a thromboxane A2/prostaglandin H2 agonist [3H]U46619 to washed human platelets. Prostaglandins. 1987 Jun; 33(6):789-97. PMID: 2959986.
      Citations: 7     Fields:    Translation:HumansCells
    173. Halushka PV, Kochel PJ, Mais DE, Halushka PV, Kochel PJ, Mais DE. Binding of thromboxane A2/prostaglandin H2 agonists to human platelets. Br J Pharmacol. 1987 May; 91(1):223-7. PMID: 3594077; PMCID: PMC1853501.
      Citations: 3     Fields:    Translation:HumansCells
    174. Smith EF, Wise WC, Halushka PV, Cook JA, Smith EF, Wise WC, Halushka PV, Cook JA. Macrophage eicosanoid formation is stimulated by platelet arachidonic acid and prostaglandin endoperoxide transfer. Biochim Biophys Acta. 1987 Mar 19; 923(3):355-61. PMID: 3103691.
      Citations: 2     Fields:    Translation:AnimalsCells
    175. Fuhrman TM, Hollon MF, Reines HD, Olanoff LS, Halushka PV, Fuhrman TM, Hollon MF, Reines HD, Olanoff LS, Halushka PV. Beneficial effects of ibuprofen in oleic acid induced lung injury. J Surg Res. 1987 Mar; 42(3):284-9. PMID: 3102855.
      Citations: 2     Fields:    Translation:AnimalsCells
    176. Hubbard HL, Eller TD, Mais DE, Halushka PV, Baker RH, Blair IA, Vrbanac JJ, Knapp DR, Hubbard HL, Eller TD, Mais DE, Halushka PV, Baker RH, Blair IA, Vrbanac JJ, Knapp DR. Extraction of thromboxane B2 from urine using an immobilized antibody column for subsequent analysis by gas chromatography-mass spectrometry. Prostaglandins. 1987 Feb; 33(2):149-60. PMID: 3588968.
      Citations: 3     Fields:    Translation:Humans
    177. Etemadi AR, Tempel GE, Farah BA, Wise WC, Halushka PV, Cook JA, Etemadi AR, Tempel GE, Farah BA, Wise WC, Halushka PV, Cook JA. Beneficial effects of a leukotriene antagonist on endotoxin-induced acute hemodynamic alterations. Circ Shock. 1987; 22(1):55-63. PMID: 3038364.
      Citations: 5     Fields:    Translation:AnimalsCells
    178. Katz SA, Halushka PV, Wise WC, Cook JA, Katz SA, Halushka PV, Wise WC, Cook JA. Oleic acid induces pulmonary injury independent of eicosanoids in the isolated, perfused rabbit lung. Circ Shock. 1987; 22(3):221-30. PMID: 3113757.
      Citations: 2     Fields:    Translation:Animals
    179. Halushka PV, Lefer AM, Halushka PV, Lefer AM. Thromboxane A2 in health and disease. Fed Proc. 1987 Jan; 46(1):131-2. PMID: 3542572.
      Citations: 4     Fields:    Translation:Humans
    180. Halushka PV, Mais DE, Saussy DL, Halushka PV, Mais DE, Saussy DL. Platelet and vascular smooth muscle thromboxane A2/prostaglandin H2 receptors. Fed Proc. 1987 Jan; 46(1):149-53. PMID: 2948839.
      Citations: 5     Fields:    Translation:HumansCells
    181. Halushka PV, Mais DE, Garvin M, Halushka PV, Mais DE, Garvin M. Binding of a thromboxane A2/prostaglandin H2 receptor antagonist to guinea-pig platelets. Eur J Pharmacol. 1986 Nov 12; 131(1):49-54. PMID: 3816947.
      Citations: 2     Fields:    Translation:AnimalsCells
    182. Mais DE, Burch RM, Oatis JE, Knapp DR, Halushka PV, Mais DE, Burch RM, Oatis JE, Knapp DR, Halushka PV. Photoaffinity labelling of a thromboxane A2/prostaglandin H2 antagonist binding site in human platelets. Biochem Biophys Res Commun. 1986 Oct 15; 140(1):128-33. PMID: 2946292.
      Citations:    Fields:    Translation:HumansCells
    183. Hsu CY, Halushka PV, Hogan EL, Cox RD, Hsu CY, Halushka PV, Hogan EL, Cox RD. Increased thromboxane level in experimental spinal cord injury. J Neurol Sci. 1986 Jul; 74(2-3):289-96. PMID: 3525758.
      Citations: 4     Fields:    Translation:Animals
    184. Chaikhouni A, Crawford FA, Kochel PJ, Olanoff LS, Halushka PV, Chaikhouni A, Crawford FA, Kochel PJ, Olanoff LS, Halushka PV. Human internal mammary artery produces more prostacyclin than saphenous vein. J Thorac Cardiovasc Surg. 1986 Jul; 92(1):88-91. PMID: 3755199.
      Citations: 8     Fields:    Translation:Humans
    185. Tempel GE, Cook JA, Wise WC, Halushka PV, Corral D, Tempel GE, Cook JA, Wise WC, Halushka PV, Corral D. Improvement in organ blood flow by inhibition of thromboxane synthetase during experimental endotoxic shock in the rat. J Cardiovasc Pharmacol. 1986 May-Jun; 8(3):514-9. PMID: 2425166.
      Citations: 4     Fields:    Translation:AnimalsCells
    186. Rogers TS, Halushka PV, Wise WC, Cook JA, Rogers TS, Halushka PV, Wise WC, Cook JA. Differential alteration of lipoxygenase and cyclooxygenase metabolism by rat peritoneal macrophages induced by endotoxin tolerance. Prostaglandins. 1986 Apr; 31(4):639-50. PMID: 3088676.
      Citations: 3     Fields:    Translation:AnimalsCells
    187. Chen ST, Hsu CY, Hogan EL, Halushka PV, Linet OI, Yatsu FM, Chen ST, Hsu CY, Hogan EL, Halushka PV, Linet OI, Yatsu FM. Thromboxane, prostacyclin, and leukotrienes in cerebral ischemia. Neurology. 1986 Apr; 36(4):466-70. PMID: 3008026.
      Citations: 12     Fields:    Translation:Cells
    188. Saussy DL, Mais DE, Burch RM, Halushka PV, Saussy DL, Mais DE, Burch RM, Halushka PV. Identification of a putative thromboxane A2/prostaglandin H2 receptor in human platelet membranes. J Biol Chem. 1986 Mar 05; 261(7):3025-9. PMID: 3005276.
      Citations: 7     Fields:    Translation:HumansCells
    189. Armstrong J, Tempel GE, Cook JA, Wise WC, Halushka PV, Armstrong J, Tempel GE, Cook JA, Wise WC, Halushka PV. The effects of alpha adrenergic blockade on arachidonic acid metabolism and shock sequelae in endotoxemia. Circ Shock. 1986; 20(2):151-9. PMID: 3096591.
      Citations: 1     Fields:    Translation:Animals
    190. Ball HA, Cook JA, Wise WC, Halushka PV, Ball HA, Cook JA, Wise WC, Halushka PV. Role of thromboxane, prostaglandins and leukotrienes in endotoxic and septic shock. Intensive Care Med. 1986; 12(3):116-26. PMID: 3016060.
      Citations: 23     Fields:    Translation:HumansAnimals
    191. Saussy DL, Mais DE, Knapp DR, Halushka PV, Saussy DL, Mais DE, Knapp DR, Halushka PV. Thromboxane A2 and prostaglandin endoperoxide receptors in platelets and vascular smooth muscle. Circulation. 1985 Dec; 72(6):1202-7. PMID: 2998641.
      Citations: 6     Fields:    Translation:HumansCells
    192. Halushka PV, Mayfield R, Colwell JA, Halushka PV, Mayfield R, Colwell JA. Insulin and arachidonic acid metabolism in diabetes mellitus. Metabolism. 1985 Dec; 34(12 Suppl 1):32-6. PMID: 3934501.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    193. Mais DE, Burch RM, Saussy DL, Kochel PJ, Halushka PV, Mais DE, Burch RM, Saussy DL, Kochel PJ, Halushka PV. Binding of a thromboxane A2/prostaglandin H2 receptor antagonist to washed human platelets. J Pharmacol Exp Ther. 1985 Dec; 235(3):729-34. PMID: 3001275.
      Citations: 6     Fields:    Translation:HumansCells
    194. Burch RM, Mais DE, Pepkowitz SH, Halushka PV, Burch RM, Mais DE, Pepkowitz SH, Halushka PV. Hydrodynamic properties of a thromboxane A2/prostaglandin H2 antagonist binding site solubilized from human platelets. Biochem Biophys Res Commun. 1985 Nov 15; 132(3):961-8. PMID: 3000368.
      Citations:    Fields:    Translation:HumansCells
    195. Mayfield RK, Halushka PV, Wohltmann HJ, Lopes-Virella M, Chambers JK, Loadholt CB, Colwell JA, Mayfield RK, Halushka PV, Wohltmann HJ, Lopes-Virella M, Chambers JK, Loadholt CB, Colwell JA. Platelet function during continuous insulin infusion treatment in insulin-dependent diabetic patients. Diabetes. 1985 Nov; 34(11):1127-33. PMID: 3930325.
      Citations: 6     Fields:    Translation:HumansCells
    196. Cook JA, Wise WC, Halushka PV, Cook JA, Wise WC, Halushka PV. Protective effect of a selective leukotriene antagonist in endotoxemia in the rat. J Pharmacol Exp Ther. 1985 Nov; 235(2):470-4. PMID: 2997435.
      Citations: 11     Fields:    Translation:AnimalsCells
    197. Burch RM, Mais DE, Saussy DL, Halushka PV, Burch RM, Mais DE, Saussy DL, Halushka PV. Solubilization of a thromboxane A2/prostaglandin H2 antagonist binding site from human platelets. Proc Natl Acad Sci U S A. 1985 Nov; 82(21):7434-8. PMID: 2997791; PMCID: PMC391359.
      Citations: 4     Fields:    Translation:HumansCells
    198. Baron DA, Burch RM, Halushka PV, Spicer SS, Baron DA, Burch RM, Halushka PV, Spicer SS. Blockade of colchicine-induced inhibition of vasopressin-stimulated osmotic water flow: failure to influence microtubule formation. Am J Physiol. 1985 Oct; 249(4 Pt 2):F464-9. PMID: 3931483.
      Citations: 1     Fields:    Translation:AnimalsCells
    199. Mais DE, Kochel PJ, Saussy DL, Halushka PV, Mais DE, Kochel PJ, Saussy DL, Halushka PV. Binding of an 125I-labeled thromboxane A2/prostaglandin H2 receptor antagonist to washed canine platelets. Mol Pharmacol. 1985 Aug; 28(2):163-9. PMID: 2991736.
      Citations: 4     Fields:    Translation:AnimalsCells
    200. Hsu CY, Halushka PV, Hogan EL, Banik NL, Lee WA, Perot PL, Hsu CY, Halushka PV, Hogan EL, Banik NL, Lee WA, Perot PL. Alteration of thromboxane and prostacyclin levels in experimental spinal cord injury. Neurology. 1985 Jul; 35(7):1003-9. PMID: 3892363.
      Citations: 9     Fields:    Translation:Animals
    201. Dorn GW, Halushka PV, Dorn GW, Halushka PV. Thromboxane synthetase inhibitors, thromboxane receptor antagonists, and aspirin in cardiovascular disease. Ration Drug Ther. 1985 Jul; 19(7):1-7. PMID: 2997839.
      Citations: 1     Fields:    Translation:HumansAnimalsCTClinical Trials
    202. Olanoff LS, Cook JA, Halushka PV, Olanoff LS, Cook JA, Halushka PV. Sulindac does not preserve renal prostacyclin synthesis during endotoxemia. Prostaglandins. 1985 Jun; 29(6):1031-7. PMID: 3898231.
      Citations:    Fields:    Translation:Animals
    203. Halushka PV, Reines HD, Barrow SE, Blair IA, Dollery CT, Rambo W, Cook JA, Wise WC, Halushka PV, Reines HD, Barrow SE, Blair IA, Dollery CT, Rambo W, Cook JA, Wise WC. Elevated plasma 6-keto-prostaglandin F1 alpha in patients in septic shock. Crit Care Med. 1985 Jun; 13(6):451-3. PMID: 3838926.
      Citations: 10     Fields:    Translation:Humans
    204. Mais DE, Saussy DL, Chaikhouni A, Kochel PJ, Knapp DR, Hamanaka N, Halushka PV, Mais DE, Saussy DL, Chaikhouni A, Kochel PJ, Knapp DR, Hamanaka N, Halushka PV. Pharmacologic characterization of human and canine thromboxane A2/prostaglandin H2 receptors in platelets and blood vessels: evidence for different receptors. J Pharmacol Exp Ther. 1985 May; 233(2):418-24. PMID: 2987481.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    205. Mais DE, Dunlap C, Hamanaka N, Halushka PV, Mais DE, Dunlap C, Hamanaka N, Halushka PV. Further studies on the effects of epimers of thromboxane A2 antagonists on platelets and veins. Eur J Pharmacol. 1985 Apr 23; 111(1):125-8. PMID: 4018122.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    206. Orr RK, Hoehn JL, Col NF, Halushka PV, MacDermot J, Knapp DR, Eller T, Saussy DL, Mais D, Blair IA, Dollery CT. A novel approach for the study of thromboxane A2 and prostaglandin H2 receptors using an 125I-labeled ligand. Biochem Pharmacol. 1985 Apr 15; 34(8):1165-70. PMID: 2986639.
      Citations: 4     Fields:    Translation:HumansCells
    207. Reines HD, Halushka PV, Olanoff LS, Hunt PS, Reines HD, Halushka PV, Olanoff LS, Hunt PS. Dazoxiben in human sepsis and adult respiratory distress syndrome. Clin Pharmacol Ther. 1985 Apr; 37(4):391-5. PMID: 3979000.
      Citations: 6     Fields:    Translation:HumansCTClinical Trials
    208. Reines HD, Halushka PV, Cook JA, Loadholt CB, Reines HD, Halushka PV, Cook JA, Loadholt CB. Lack of effect of glucocorticoids upon plasma thromboxane in patients in a state of shock. Surg Gynecol Obstet. 1985 Apr; 160(4):320-2. PMID: 3983796.
      Citations: 3     Fields:    Translation:Humans
    209. Cook JA, Wise WC, Tempel GE, Halushka PV, Cook JA, Wise WC, Tempel GE, Halushka PV. Exchange transfusions in rats with a perfluorated blood substitute: effect on thromboxane B2 levels during endotoxemia. Circ Shock. 1985; 15(3):193-204. PMID: 3978769.
      Citations: 1     Fields:    Translation:Animals
    210. Smith EF, Tempel GE, Wise WC, Halushka PV, Cook JA, Smith EF, Tempel GE, Wise WC, Halushka PV, Cook JA. Experimental endotoxemia in the rat: efficacy of prostacyclin or the prostacyclin analog iloprost. Circ Shock. 1985; 16(1):1-7. PMID: 2414027.
      Citations: 4     Fields:    Translation:AnimalsCells
    211. Olanoff LS, Cook JA, Eller T, Knapp DR, Halushka PV, Olanoff LS, Cook JA, Eller T, Knapp DR, Halushka PV. Protective effects of trans-13-APT, a thromboxane receptor antagonist, in endotoxemia. J Cardiovasc Pharmacol. 1985 Jan-Feb; 7(1):114-20. PMID: 2580129.
      Citations: 6     Fields:    Translation:AnimalsCells
    212. Wise WC, Halushka PV, Knapp RG, Cook JA, Wise WC, Halushka PV, Knapp RG, Cook JA. Ibuprofen, methylprednisolone, and gentamicin as conjoint therapy in septic shock. Circ Shock. 1985; 17(1):59-71. PMID: 3840416.
      Citations: 5     Fields:    Translation:Animals
    213. Margolius HS, Halushka PV, Chao J, Miller DH, Cuthbert AW, Spayne JA, Margolius HS, Halushka PV, Chao J, Miller DH, Cuthbert AW, Spayne JA. Studies of the kallikrein-kinin system and prostaglandins in epithelial ion transport. Soc Gen Physiol Ser. 1985; 39:121-33. PMID: 3920759.
      Citations: 2     Fields:    Translation:HumansAnimals
    214. Burch RM, Halushka PV, Burch RM, Halushka PV. ADH or theophylline-induced changes in intracellular free and membrane-bound calcium. Am J Physiol. 1984 Dec; 247(6 Pt 2):F939-45. PMID: 6439053.
      Citations: 5     Fields:    Translation:AnimalsCells
    215. Cuthbert AW, Halushka PV, Kessel D, Margolius HS, Wise WC, Cuthbert AW, Halushka PV, Kessel D, Margolius HS, Wise WC. Kinin effects on chloride secretion do not require eicosanoid synthesis. Br J Pharmacol. 1984 Oct; 83(2):549-54. PMID: 6593108; PMCID: PMC1987109.
      Citations: 9     Fields:    Translation:Animals
    216. Cuthbert AW, Halushka PV, Margolius HS, Spayne JA, Cuthbert AW, Halushka PV, Margolius HS, Spayne JA. Role of calcium ions in kinin-induced chloride secretion. Br J Pharmacol. 1984 Jul; 82(3):587-95. PMID: 6331558; PMCID: PMC1987009.
      Citations: 14     Fields:    Translation:Animals
    217. Cuthbert AW, Halushka PV, Margolius HS, Spayne JA, Cuthbert AW, Halushka PV, Margolius HS, Spayne JA. Mediators of the secretory response to kinins. Br J Pharmacol. 1984 Jul; 82(3):597-607. PMID: 6331559; PMCID: PMC1986995.
      Citations: 22     Fields:    Translation:AnimalsCells
    218. Olanoff LS, Reines HD, Spicer KM, Halushka PV, Olanoff LS, Reines HD, Spicer KM, Halushka PV. Effects of oleic acid on pulmonary capillary leak and thromboxanes. J Surg Res. 1984 Jun; 36(6):597-605. PMID: 6233456.
      Citations: 1     Fields:    Translation:AnimalsCells
    219. Burch RM, Halushka PV, Burch RM, Halushka PV. Alterations in extracellular calcium concentration differentially influence prostaglandin and thromboxane synthesis in epithelial cells from the toad urinary bladder. Arch Biochem Biophys. 1984 Feb 15; 229(1):90-7. PMID: 6422855.
      Citations:    Fields:    Translation:Animals
    220. Rogers TS, Smith EF, Wise WC, Halushka PV, Cook JA, Rogers TS, Smith EF, Wise WC, Halushka PV, Cook JA. Interaction of eicosanoids and macrophages during inflammatory responses. Surv Immunol Res. 1984; 3(2-3):161-4. PMID: 6718845.
      Citations: 2     Fields:    Translation:AnimalsCells
    221. Cook JA, Wise WC, Butler RR, Reines HD, Rambo W, Halushka PV, Cook JA, Wise WC, Butler RR, Reines HD, Rambo W, Halushka PV. The potential role of thromboxane and prostacyclin in endotoxic and septic shock. Am J Emerg Med. 1984 Jan; 2(1):28-37. PMID: 6440569.
      Citations: 2     Fields:    Translation:Animals
    222. Colwell JA, Winocour PD, Lopes-Virella M, Halushka PV, Colwell JA, Winocour PD, Lopes-Virella M, Halushka PV. New concepts about the pathogenesis of atherosclerosis in diabetes mellitus. Am J Med. 1983 Nov 30; 75(5B):67-80. PMID: 6424441.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    223. Burch RM, Wise WC, Halushka PV, Burch RM, Wise WC, Halushka PV. Prostaglandin-independent inhibition of calcium transport by nonsteroidal anti-inflammatory drugs: differential effects of carboxylic acids and piroxicam. J Pharmacol Exp Ther. 1983 Oct; 227(1):84-91. PMID: 6312024.
      Citations: 12     Fields:    Translation:AnimalsCells
    224. Orr RK, Hoehn JL, Col NF, Chong KP, Burch RM, Black M, Maloney E, Jollow DJ, Halushka PV. Vasopressin stimulates thromboxane synthesis in isolated hamster hepatocytes: relation to hepatocyte calcium content. Prostaglandins. 1983 Sep; 26(3):397-408. PMID: 6419286.
      Citations: 1     Fields:    Translation:Animals
    225. Burch RM, Halushka PV, Burch RM, Halushka PV. Verapamil inhibition of vasopressin-stimulated water flow: possible role of intracellular calcium. J Pharmacol Exp Ther. 1983 Sep; 226(3):701-5. PMID: 6411896.
      Citations: 1     Fields:    Translation:Animals
    226. Halushka PV, Wise WC, Cook JA, Halushka PV, Wise WC, Cook JA. Studies on the beneficial effects of aspirin in endotoxic shock. Relationship to inhibition of arachidonic acid metabolism. Am J Med. 1983 Jun 14; 74(6A):91-6. PMID: 6687979.
      Citations: 9     Fields:    Translation:AnimalsCells
    227. Colwell JA, Winocour PD, Halushka PV, Colwell JA, Winocour PD, Halushka PV. Do platelets have anything to do with diabetic microvascular disease? Diabetes. 1983 May; 32 Suppl 2:14-9. PMID: 6242836.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    228. Butler RR, Wise WC, Halushka PV, Cook JA, Butler RR, Wise WC, Halushka PV, Cook JA. Gentamicin and indomethacin in the treatment of septic shock: effects on prostacyclin and thromboxane A2 production. J Pharmacol Exp Ther. 1983 Apr; 225(1):94-101. PMID: 6339712.
      Citations: 6     Fields:    Translation:AnimalsCells
    229. Anderegg K, Anzeveno P, Cook JA, Halushka PV, McCarthy J, Wagner E, Wise WC, Anderegg K, Anzeveno P, Cook JA, Halushka PV, McCarthy J, Wagner E, Wise WC. Effects of a pyridine derivative thromboxane synthetase inhibitor and its inactive isomer in endotoxic shock in the rat. Br J Pharmacol. 1983 Apr; 78(4):725-32. PMID: 6687819; PMCID: PMC2044743.
      Citations: 3     Fields:    Translation:AnimalsCells
    230. Newman WH, Frankis MB, Halushka PV, Newman WH, Frankis MB, Halushka PV. Increased myocardial release of prostacyclin in dogs with heart failure. J Cardiovasc Pharmacol. 1983 Mar-Apr; 5(2):194-201. PMID: 6188889.
      Citations: 7     Fields:    Translation:Animals
    231. Halushka PV, Dollery CT, MacDermot J, Halushka PV, Dollery CT, MacDermot J. Thromboxane and prostacyclin in disease: a review. Q J Med. 1983; 52(208):461-70. PMID: 6361838.
      Citations: 2     Fields:    Translation:HumansAnimals
    232. Hohn AR, Riopel DA, Keil JE, Loadholt CB, Margolius HS, Halushka PV, Privitera PJ, Webb JG, Medley ES, Schuman SH, Rubin MI, Pantell RH, Braunstein ML, Hohn AR, Riopel DA, Keil JE, Loadholt CB, Margolius HS, Halushka PV, Privitera PJ, Webb JG, Medley ES, Schuman SH, Rubin MI, Pantell RH, Braunstein ML. Childhood familial and racial differences in physiologic and biochemical factors related to hypertension. Hypertension. 1983 Jan-Feb; 5(1):56-70. PMID: 6336720.
      Citations: 4     Fields:    Translation:Humans
    233. Burch RM, Halushka PV, Burch RM, Halushka PV. 45Ca fluxes in isolated toad bladder epithelial cells: effects of agents which alter water or sodium transport. J Pharmacol Exp Ther. 1983 Jan; 224(1):108-17. PMID: 6294273.
      Citations: 4     Fields:    Translation:Animals
    234. Halushka PV, Cook JA, Wise WC, Halushka PV, Cook JA, Wise WC. Beneficial effects of UK 37248, a thromboxane synthetase inhibitor, in experimental endotoxic shock in the rat. Br J Clin Pharmacol. 1983; 15 Suppl 1:133S-139S. PMID: 6337604; PMCID: PMC1427698.
      Citations: 7     Fields:    Translation:AnimalsCells
    235. Wise WC, Cook JA, Halushka PV, Wise WC, Cook JA, Halushka PV. Arachidonic acid metabolism in endotoxin tolerance. Adv Shock Res. 1983; 10:131-42. PMID: 6410699.
      Citations: 3     Fields:    Translation:AnimalsCells
    236. Burch RM, Halushka PV, Burch RM, Halushka PV. Vasopressin stimulates prostaglandin and thromboxane synthesis in toad bladder epithelial cells. Am J Physiol. 1982 Dec; 243(6):F593-7. PMID: 6816073.
      Citations: 2     Fields:    Translation:Animals
    237. Kelley VE, Izui S, Halushka PV, Kelley VE, Izui S, Halushka PV. Effect of ibuprofen, a fatty acid cyclooxygenase inhibitor, on murine lupus. Clin Immunol Immunopathol. 1982 Nov; 25(2):223-31. PMID: 6819912.
      Citations: 5     Fields:    Translation:Animals
    238. Wilson TW, Loadholt CB, Privitera PJ, Halushka PV, Wilson TW, Loadholt CB, Privitera PJ, Halushka PV. Furosemide increases urine 6-keto-prostaglandin F1 alpha. Relation to natriuresis, vasodilation, and renin release. Hypertension. 1982 Sep-Oct; 4(5):634-41. PMID: 7049918.
      Citations: 6     Fields:    Translation:Animals
    239. Reines HD, Halushka PV, Cook JA, Wise WC, Rambo W, Reines HD, Halushka PV, Cook JA, Wise WC, Rambo W. Plasma thromboxane concentrations are raised in patients dying with septic shock. Lancet. 1982 Jul 24; 2(8291):174-5. PMID: 6123885.
      Citations: 14     Fields:    Translation:Humans
    240. Colwell JA, Halushka PV, Colwell JA, Halushka PV. Platelets, prostaglandins, and coagulation in diabetes mellitus. Mt Sinai J Med. 1982 May-Jun; 49(3):215-22. PMID: 6811864.
      Citations: 1     Fields:    Translation:HumansCells
    241. Tempel GE, Cook JA, Wise WC, Halushka PV, Tempel GE, Cook JA, Wise WC, Halushka PV. The improvement in endotoxin-induced redistribution of organ blood flow by inhibition of thromboxane and prostaglandin synthesis. Adv Shock Res. 1982; 7:209-18. PMID: 6753535.
      Citations: 2     Fields:    Translation:AnimalsCells
    242. Butler RR, Wise WC, Halushka PV, Cook JA, Butler RR, Wise WC, Halushka PV, Cook JA. Thromboxane and prostacyclin production during septic shock. Adv Shock Res. 1982; 7:133-45. PMID: 6753528.
      Citations: 3     Fields:    Translation:Animals
    243. Cook JA, Halushka PV, Wise WC, Cook JA, Halushka PV, Wise WC. Modulation of macrophage arachidonic acid metabolism: potential role in the susceptibility of rats to endotoxic shock. Circ Shock. 1982; 9(6):605-17. PMID: 7151266.
      Citations: 7     Fields:    Translation:AnimalsCells
    244. Burch RM, Halushka PV, Burch RM, Halushka PV. Inhibition of prostaglandin synthesis antagonizes the colchicine-induced reduction of vasopressin-stimulated water flow in the toad urinary bladder. Mol Pharmacol. 1982 Jan; 21(1):142-9. PMID: 6290865.
      Citations: 2     Fields:    Translation:Animals
    245. Russel MP, Privitera PJ, Walle T, Peet NP, Halushka PV, Gaffney TE, Russel MP, Privitera PJ, Walle T, Peet NP, Halushka PV, Gaffney TE. Cardiovascular effects of a 4'-methylthio analog of propranolol. J Pharmacol Exp Ther. 1981 Dec; 219(3):685-90. PMID: 6117655.
      Citations:    Fields:    Translation:HumansAnimals
    246. Grimm LJ, Knapp DR, Senator D, Halushka PV, Grimm LJ, Knapp DR, Senator D, Halushka PV. Inhibition of platelet thromboxane synthesis by 7-(1-imidazolyl) heptanoic acid: dissociation from inhibition of aggregation. Thromb Res. 1981 Nov 15; 24(4):307-17. PMID: 6801806.
      Citations: 9     Fields:    Translation:HumansCells
    247. Cook JA, Wise WC, Halushka PV, Cook JA, Wise WC, Halushka PV. Thromboxane A2 and prostacyclin production by lipopolysaccharide-stimulated peritoneal macrophages. J Reticuloendothel Soc. 1981 Nov; 30(5):445-50. PMID: 7033530.
      Citations: 6     Fields:    Translation:AnimalsCells
    248. Halushka PV, Wise WC, Cook JA, Halushka PV, Wise WC, Cook JA. Protective effects of aspirin in endotoxic shock. J Pharmacol Exp Ther. 1981 Aug; 218(2):464-9. PMID: 6894770.
      Citations: 12     Fields:    Translation:AnimalsCells
    249. Halushka PV, Rogers RC, Loadholt CB, Wohltman H, Mayfield R, McCoy S, Colwell JA, Halushka PV, Rogers RC, Loadholt CB, Wohltman H, Mayfield R, McCoy S, Colwell JA. Increased platelet prostaglandin and thromboxane synthesis in diabetes mellitus. Horm Metab Res Suppl. 1981; 11:7-11. PMID: 7033097.
      Citations: 2     Fields:    Translation:HumansCells
    250. Wise WC, Cook JA, Halushka PV, Wise WC, Cook JA, Halushka PV. Implications for thromboxane A2 in the pathogenesis of endotoxic shock. Adv Shock Res. 1981; 6:83-91. PMID: 6961767.
      Citations: 5     Fields:    Translation:Animals
    251. Cook JA, Wise WC, Knapp DR, Halushka PV, Cook JA, Wise WC, Knapp DR, Halushka PV. Sensitization of essential fatty acid-deficient rats to endotoxin by arachidonate pretreatment: role of thromboxane A2. Circ Shock. 1981; 8(1):69-76. PMID: 7237685.
      Citations: 1     Fields:    Translation:Animals
    252. Halushka PV, Mayfield R, Wohltmann HJ, Rogers RC, Goldberg AK, McCoy SA, Loadholt CB, Colwell JA, Halushka PV, Mayfield R, Wohltmann HJ, Rogers RC, Goldberg AK, McCoy SA, Loadholt CB, Colwell JA. Increased platelet arachidonic acid metabolism in diabetes mellitus. Diabetes. 1981; 30(Suppl 2):44-8. PMID: 6795072.
      Citations: 2     Fields:    Translation:HumansCells
    253. Halushka PV, Rogers RC, Loadholt CB, Colwell JA, Halushka PV, Rogers RC, Loadholt CB, Colwell JA. Increased platelet thromboxane synthesis in diabetes mellitus. J Lab Clin Med. 1981 Jan; 97(1):87-96. PMID: 7452084.
      Citations: 31     Fields:    Translation:HumansCells
    254. Colwell JA, Lopes-Virella M, Halushka PV, Colwell JA, Lopes-Virella M, Halushka PV. Pathogenesis of atherosclerosis in diabetes mellitus. Diabetes Care. 1981 Jan-Feb; 4(1):121-33. PMID: 7009108.
      Citations: 20     Fields:    Translation:HumansCells
    255. Cook JA, Wise WC, Knapp DR, Halushka PV, Cook JA, Wise WC, Knapp DR, Halushka PV. Essential fatty acid deficient rats: a new model for evaluating arachidonate metabolism in shock. Adv Shock Res. 1981; 6:93-105. PMID: 6818852.
      Citations: 5     Fields:    Translation:Animals
    256. Burch RM, Halushka PV, Burch RM, Halushka PV. Thromboxane and stable prostaglandin endoperoxide analogs stimulate water permeability in the toad urinary bladder. J Clin Invest. 1980 Dec; 66(6):1251-7. PMID: 6777398; PMCID: PMC371609.
      Citations: 2     Fields:    Translation:Animals
    257. Wise WC, Cook JA, Eller T, Halushka PV, Wise WC, Cook JA, Eller T, Halushka PV. Ibuprofen improves survival from endotoxic shock in the rat. J Pharmacol Exp Ther. 1980 Oct; 215(1):160-4. PMID: 7452480.
      Citations: 16     Fields:    Translation:AnimalsCells
    258. Burch RM, Knapp DR, Halushka PV, Burch RM, Knapp DR, Halushka PV. Vasopressin-stimulated water flow is decreased by thromboxane synthesis inhibition or antagonism. Am J Physiol. 1980 Aug; 239(2):F160-6. PMID: 6773424.
      Citations: 2     Fields:    Translation:Animals
    259. Wise WC, Cook JA, Halushka PV, Knapp DR, Wise WC, Cook JA, Halushka PV, Knapp DR. Protective effects of thromboxane synthetase inhibitors in rats in endotoxic shock. Circ Res. 1980 Jun; 46(6):854-9. PMID: 7189697.
      Citations: 22     Fields:    Translation:AnimalsCells
    260. Halushka PV, Levanho A, Auber M, Halushka PV, Levanho A, Auber M. Arachidonic acid stimulates short-circuit current in the isolated toad urinary bladder. J Pharmacol Exp Ther. 1980 Jun; 213(3):462-7. PMID: 6782235.
      Citations: 2     Fields:    Translation:Animals
    261. Colwell JA, Halushka PV, Colwell JA, Halushka PV. Platelet function in diabetes mellitus. Br J Haematol. 1980 Apr; 44(4):521-6. PMID: 6769461.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    262. Korn JH, Halushka PV, LeRoy EC, Korn JH, Halushka PV, LeRoy EC. Mononuclear cell modulation of connective tissue function: suppression of fibroblast growth by stimulation of endogenous prostaglandin production. J Clin Invest. 1980 Feb; 65(2):543-54. PMID: 7356693; PMCID: PMC371393.
      Citations: 58     Fields:    Translation:HumansCells
    263. Halushka PV, Levanho A, Auber M, Halushka PV, Levanho A, Auber M. Prostacyclin stimulates short circuit current in the isolated toad (Bufo marinus) urinary bladder. Adv Prostaglandin Thromboxane Res. 1980; 8:1269-72. PMID: 6769307.
      Citations: 1     Fields:    Translation:Animals
    264. Burch RM, Knapp DR, Halushka PV, Burch RM, Knapp DR, Halushka PV. Vasopressin stimulates thromboxane synthesis in the toad urinary bladder: effects of thromboxane synthesis inhibition. Adv Prostaglandin Thromboxane Res. 1980; 6:505-9. PMID: 6770606.
      Citations:    Fields:    Translation:Animals
    265. Cook JA, Wise WC, Halushka PV, Cook JA, Wise WC, Halushka PV. Elevated thromboxane levels in the rat during endotoxic shock: protective effects of imidazole, 13-azaprostanoic acid, or essential fatty acid deficiency. J Clin Invest. 1980 Jan; 65(1):227-30. PMID: 7350199; PMCID: PMC371359.
      Citations: 51     Fields:    Translation:Animals
    266. Burch RM, Knapp DR, Halushka PV, Burch RM, Knapp DR, Halushka PV. Vasopressin stimulates thromboxane synthesis in the toad urinary bladder: effects of imidazole. J Pharmacol Exp Ther. 1979 Sep; 210(3):344-8. PMID: 113526.
      Citations: 22     Fields:    Translation:Animals
    267. Halushka PV, Margolius HS, Allen H, Conradi EC, Halushka PV, Margolius HS, Allen H, Conradi EC. Urinary excretion of prostaglandin E like material and kallikrein: effects of furosemide. Prostaglandins. 1979 Sep; 18(3):359-68. PMID: 260996.
      Citations: 5     Fields:    Translation:Humans
    268. Le Breton GC, Venton DL, Enke SE, Halushka PV, Le Breton GC, Venton DL, Enke SE, Halushka PV. 13-Azaprostanoic acid: a specific antagonist of the human blood platelet thromboxane/endoperoxide receptor. Proc Natl Acad Sci U S A. 1979 Aug; 76(8):4097-101. PMID: 291066; PMCID: PMC383985.
      Citations: 19     Fields:    Translation:HumansCells
    269. Colwell JA, Nair RM, Halushka PV, Rogers C, Whetsell A, Sagel J, Colwell JA, Nair RM, Halushka PV, Rogers C, Whetsell A, Sagel J. Platelet adhesion and aggregation in diabetes mellitus. Metabolism. 1979 Apr; 28(4 Suppl 1):394-400. PMID: 122293.
      Citations: 10     Fields:    Translation:HumansCells
    270. Hsu CY, Knapp DR, Halushka PV, Hsu CY, Knapp DR, Halushka PV. The effects of alpha adrenergic agents on human platelet aggregation. J Pharmacol Exp Ther. 1979 Mar; 208(3):366-70. PMID: 34707.
      Citations: 24     Fields:    Translation:Humans
    271. Colwell JA, Halushka PV, Sarji KE, Lopes-Virella MF, Sagel J, Colwell JA, Halushka PV, Sarji KE, Lopes-Virella MF, Sagel J. Vascular disease in diabetes: pathophysiological mechanisms and therapy. Arch Intern Med. 1979 Feb; 139(2):225-30. PMID: 434977.
      Citations: 15     Fields:    Translation:Humans
    272. Halushka PV, Knapp DR, Grimm L, Halushka PV, Knapp DR, Grimm L. Prostaglandins, thromboxanes, and platelet function. Curr Top Hematol. 1979; 2:75-143. PMID: 233629.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    273. Webb JG, Saelens DA, Halushka PV, Webb JG, Saelens DA, Halushka PV. Biosynthesis of prostaglandin E by rat superior cervical ganglia. J Neurochem. 1978 Jul; 31(1):13-9. PMID: 209139.
      Citations: 6     Fields:    Translation:Animals
    274. Maxwell WA, Halushka PV, Miller RL, Spicer SS, Westphal MC, Penny LD, Maxwell WA, Halushka PV, Miller RL, Spicer SS, Westphal MC, Penny LD. Elevated prostaglandin production in cultured cells from a patient with fibrodysplasia ossificans progressiva. Prostaglandins. 1978 Jan; 15(1):123-9. PMID: 415337.
      Citations: 2     Fields:    Translation:HumansCells
    275. Halushka PV, Lurie D, Colwell JA, Halushka PV, Lurie D, Colwell JA. Increased synthesis of prostaglandin-E-like material by platelets from patients with diabetes mellitus. N Engl J Med. 1977 Dec 15; 297(24):1306-10. PMID: 917087.
      Citations: 19     Fields:    Translation:HumansCells
    276. Sawyer PR, Cowart TD, Hurwitz GA, Halushka PV, Jollow DJ, Sawyer PR, Cowart TD, Hurwitz GA, Halushka PV, Jollow DJ. Acetaminophen overdosage. J S C Med Assoc. 1977 Nov; 73(11):474-80. PMID: 270599.
      Citations:    Fields:    Translation:Humans
    277. Halushka PV, Wohltmann H, Privitera PJ, Hurwitz G, Margolius HS, Halushka PV, Wohltmann H, Privitera PJ, Hurwitz G, Margolius HS. Bartter's syndrome: urinary prostaglandin E-like material and kallikrein; indomethacin effects. Ann Intern Med. 1977 Sep; 87(3):281-6. PMID: 900671.
      Citations: 13     Fields:    Translation:Humans
    278. Miller RL, Maxwell WA, Spicer SS, Halushka PV, Varner HH, Westphal MC, Miller RL, Maxwell WA, Spicer SS, Halushka PV, Varner HH, Westphal MC. Studies on alkaline phosphatase activity cultured cells from a patient with fibrodysplasia ossificans progressiva. Lab Invest. 1977 Sep; 37(3):254-9. PMID: 408558.
      Citations:    Fields:    Translation:HumansCells
    279. Maxwell WA, Spicer SS, Miller RL, Halushka PV, Westphal MC, Setser ME, Maxwell WA, Spicer SS, Miller RL, Halushka PV, Westphal MC, Setser ME. Histochemical and ultrastructural studies in fibrodysplasia ossificans progressiva (myositis ossificans progressiva). Am J Pathol. 1977 Jun; 87(3):483-98. PMID: 141214; PMCID: PMC2032147.
      Citations: 1     Fields:    Translation:HumansCells
    280. Colwell JA, Halushka PV, Sarji K, Levine J, Sagel J, Nair RM, Colwell JA, Halushka PV, Sarji K, Levine J, Sagel J, Nair RM. Altered platelet function in diabetes mellitus. Diabetes. 1976; 25(2 SUPPL):826-31. PMID: 823064.
      Citations: 28     Fields:    Translation:HumansCells
    281. Halushka PV, Keiser HR, Halushka PV, Keiser HR. Acute effects of alpha-methyldopa on mean blood pressure and plasma renin activity. Circ Res. 1974 Sep; 35(3):458-63. PMID: 4370852.
      Citations: 1     Fields:    Translation:Animals
    282. Brereton HD, Halushka PV, Alexander RW, Mason DM, Keiser HR, DeVita VT, Brereton HD, Halushka PV, Alexander RW, Mason DM, Keiser HR, DeVita VT. Indomethacin-responsive hypercalcemia in a patient with renal-cell adenocarcinoma. N Engl J Med. 1974 Jun 11; 291(2):83-5. PMID: 4835887.
      Citations: 19     Fields:    Translation:Humans
    283. Whitsett TL, Halushka PV, Goldberg LI, Whitsett TL, Halushka PV, Goldberg LI. Attenuation of postganglionic sympathetic nerve activity by L-dopa. Circ Res. 1970 Oct; 27(4):561-70. PMID: 5507033.
      Citations: 7     Fields:    Translation:AnimalsCells
    284. Halushka PV, Hoffmann PC, Halushka PV, Hoffmann PC. Alcohol addiction and tetrahydropapaveroline. Science. 1970 Sep 11; 169(3950):1104-5. PMID: 5465178.
      Citations: 6     Fields:    Translation:HumansAnimals
    285. Halushka PV, Hoffmann PC, Halushka PV, Hoffmann PC. Distribution and metabolism of dopamine in guinea-pigs. J Pharm Pharmacol. 1968 Dec; 20(12):943-6. PMID: 4388335.
      Citations: 1     Fields:    Translation:Animals
    286. Halushka PV, Hoffmann PC, Halushka PV, Hoffmann PC. Does tetrahydroparaveroline contribute to the cardiovascular actions of dopamine? Biochem Pharmacol. 1968 Sep; 17(9):1873-80. PMID: 5688274.
      Citations: 1     Fields:    Translation:AnimalsCells
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