Penicillin-Binding Proteins

"Penicillin-Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Bacterial proteins that share the property of binding irreversibly to PENICILLINS and other ANTIBACTERIAL AGENTS derived from LACTAMS. The penicillin-binding proteins are primarily enzymes involved in CELL WALL biosynthesis including MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PEPTIDE SYNTHASES; TRANSPEPTIDASES; and HEXOSYLTRANSFERASES.

Descriptor ID	D046915
MeSH Number(s)	D08.811.710 D12.776.097.545
Concept/Terms	Penicillin-Binding Proteins Penicillin-Binding Proteins Penicillin Binding Proteins Proteins, Penicillin-Binding Penicillin-Binding Protein Penicillin Binding Protein Penicillin-Binding Protein 1A Penicillin-Binding Protein 1A Penicillin Binding Protein 1A Protein 1A, Penicillin-Binding Penicillin-Binding Protein 1b Penicillin-Binding Protein 1b Penicillin Binding Protein 1b Protein 1b, Penicillin-Binding Penicillin-Binding Protein 2 Penicillin-Binding Protein 2 Penicillin Binding Protein 2 Penicillin-Binding Protein 2a Penicillin-Binding Protein 2a Penicillin Binding Protein 2a Penicillin-Binding Protein-2a Peptidoglycan Synthetase Peptidoglycan Synthetase Synthetase, Peptidoglycan Penicillin-Binding Protein 3 Penicillin-Binding Protein 3 Penicillin Binding Protein 3 Penicillin-Binding Protein 4 Penicillin-Binding Protein 4 Penicillin Binding Protein 4 Penicillin-Binding Protein 5 Penicillin-Binding Protein 5 Penicillin Binding Protein 5 Penicillin-Binding Protein 6 Penicillin-Binding Protein 6 Penicillin Binding Protein 6 Penicillin-Binding Protein 7 Penicillin-Binding Protein 7 Penicillin Binding Protein 7 Penicillin-Binding Protein 1 Penicillin-Binding Protein 1 Penicillin Binding Protein 1 Penicillin-Binding Protein 2b Penicillin-Binding Protein 2b Penicillin Binding Protein 2b

Below are MeSH descriptors whose meaning is more general than "Penicillin-Binding Proteins".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Penicillin-Binding Proteins [D08.811.710]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Bacterial Proteins [D12.776.097]
Penicillin-Binding Proteins [D12.776.097.545]

Below are MeSH descriptors whose meaning is related to "Penicillin-Binding Proteins".

Below are MeSH descriptors whose meaning is more specific than "Penicillin-Binding Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Penicillin-Binding Proteins" by people in this website by year, and whether "Penicillin-Binding Proteins" was a major or minor topic of these publications.

Bar chart showing 12 publications over 8 distinct years, with a maximum of 3 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2005	2	0	2
2008	1	0	1
2010	2	0	2
2012	2	1	3
2016	1	0	1
2017	1	0	1
2019	0	1	1

Below are the most recent publications written about "Penicillin-Binding Proteins" by people in Profiles.

Singh A, Tomberg J, Nicholas RA, Davies C. Recognition of the ß-lactam carboxylate triggers acylation of Neisseria gonorrhoeae penicillin-binding protein 2. J Biol Chem. 2019 09 20; 294(38):14020-14032.

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Tomberg J, Fedarovich A, Vincent LR, Jerse AE, Unemo M, Davies C, Nicholas RA. Alanine 501 Mutations in Penicillin-Binding Protein 2 from Neisseria gonorrhoeae: Structure, Mechanism, and Effects on Cephalosporin Resistance and Biological Fitness. Biochemistry. 2017 02 28; 56(8):1140-1150.

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Chen W, Zhang YM, Davies C. Penicillin-Binding Protein 3 Is Essential for Growth of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2017 01; 61(1).

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Fedarovich A, Djordjevic KA, Swanson SM, Peterson YK, Nicholas RA, Davies C. High-throughput screening for novel inhibitors of Neisseria gonorrhoeae penicillin-binding protein 2. PLoS One. 2012; 7(9):e44918.

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Ito T, Hiramatsu K, Tomasz A, de Lencastre H, Perreten V, Holden MT, Coleman DC, Goering R, Giffard PM, Skov RL, Zhang K, Westh H, O'Brien F, Tenover FC, Oliveira DC, Boyle-Vavra S, Laurent F, Kearns AM, Kreiswirth B, Ko KS, Grundmann H, Sollid JE, John JF, Daum R, Soderquist B, Buist G. Guidelines for reporting novel mecA gene homologues. Antimicrob Agents Chemother. 2012 Oct; 56(10):4997-9.

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Fedarovich A, Nicholas RA, Davies C. The role of the ß5-a11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis. J Mol Biol. 2012 May 18; 418(5):316-30.

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Nicola G, Tomberg J, Pratt RF, Nicholas RA, Davies C. Crystal structures of covalent complexes of ß-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity. Biochemistry. 2010 Sep 21; 49(37):8094-104.

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Fedarovich A, Nicholas RA, Davies C. Unusual conformation of the SxN motif in the crystal structure of penicillin-binding protein A from Mycobacterium tuberculosis. J Mol Biol. 2010 Apr 23; 398(1):54-65.

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Powell AJ, Tomberg J, Deacon AM, Nicholas RA, Davies C. Crystal structures of penicillin-binding protein 2 from penicillin-susceptible and -resistant strains of Neisseria gonorrhoeae reveal an unexpectedly subtle mechanism for antibiotic resistance. J Biol Chem. 2009 Jan 09; 284(2):1202-12.

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Bressler AM, Williams T, Culler EE, Zhu W, Lonsway D, Patel JB, Nolte FS. Correlation of penicillin Binding protein 2a detection with oxacillin resistance in Staphylococcus aureus and discovery of a novel penicillin binding protein 2a mutation. J Clin Microbiol. 2005 Sep; 43(9):4541-4.

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