"Tetanus Toxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.
| Descriptor ID |
D013744
|
| MeSH Number(s) |
D12.776.097.872 D23.946.123.893
|
| Concept/Terms |
Tetanus Toxin- Tetanus Toxin
- Toxin, Tetanus
- Clostridium tetani Toxin
- Toxin, Clostridium tetani
- Tetanus Toxins
- Toxins, Tetanus
|
Below are MeSH descriptors whose meaning is more general than "Tetanus Toxin".
Below are MeSH descriptors whose meaning is more specific than "Tetanus Toxin".
This graph shows the total number of publications written about "Tetanus Toxin" by people in this website by year, and whether "Tetanus Toxin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tetanus Toxin" by people in Profiles.
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Intracellular distribution and functional importance of vesicle-associated membrane protein 2 in gastric parietal cells. Gastroenterology. 2002 Jul; 123(1):281-90.
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Lymphocyte response to tetanus toxin T-cell epitopes: effects of tetanus vaccination and concurrent malaria prophylaxis. Vaccine. 1999 Jan; 17(1):59-63.