Interleukin-6

"Interleukin-6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.

Descriptor ID	D015850
MeSH Number(s)	D12.644.276.374.465.224 D12.776.467.374.465.202 D23.529.374.465.224
Concept/Terms	Interleukin-6 Interleukin-6 Interleukin 6 IL6 B-Cell Stimulatory Factor 2 B-Cell Stimulatory Factor-2 Differentiation Factor-2, B-Cell Differentiation Factor 2, B Cell B-Cell Differentiation Factor-2 B Cell Differentiation Factor 2 BSF-2 Hybridoma Growth Factor Growth Factor, Hybridoma IFN-beta 2 Plasmacytoma Growth Factor Growth Factor, Plasmacytoma Hepatocyte-Stimulating Factor Hepatocyte Stimulating Factor MGI-2 Myeloid Differentiation-Inducing Protein Differentiation-Inducing Protein, Myeloid Myeloid Differentiation Inducing Protein B-Cell Differentiation Factor B Cell Differentiation Factor Differentiation Factor, B-Cell Differentiation Factor, B Cell IL-6 Interferon beta-2 Interferon beta 2 beta-2, Interferon B Cell Stimulatory Factor-2 B Cell Stimulatory Factor 2

Below are MeSH descriptors whose meaning is more general than "Interleukin-6".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Interleukins [D12.644.276.374.465]
Interleukin-6 [D12.644.276.374.465.224]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Interleukins [D12.776.467.374.465]
Interleukin-6 [D12.776.467.374.465.202]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Interleukins [D23.529.374.465]
Interleukin-6 [D23.529.374.465.224]

Below are MeSH descriptors whose meaning is related to "Interleukin-6".

Below are MeSH descriptors whose meaning is more specific than "Interleukin-6".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin-6" by people in this website by year, and whether "Interleukin-6" was a major or minor topic of these publications.

Bar chart showing 187 publications over 30 distinct years, with a maximum of 20 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	1	1	2
1994	2	2	4
1995	3	2	5
1996	0	6	6
1997	0	2	2
1998	0	1	1
1999	1	2	3
2000	0	1	1
2001	0	4	4
2002	0	3	3
2003	1	3	4
2004	3	2	5
2005	0	1	1
2006	1	3	4
2007	3	3	6
2008	2	5	7
2009	3	4	7
2010	2	9	11
2011	6	9	15
2012	4	7	11
2013	0	8	8
2014	3	12	15
2015	3	17	20
2016	2	6	8
2017	4	5	9
2018	3	6	9
2019	1	5	6
2020	3	4	7
2021	0	1	1
2022	1	1	2

Below are the most recent publications written about "Interleukin-6" by people in Profiles.

Lin H, Dixon SG, Hu W, Hamlett ED, Jin J, Ergul A, Wang GY. p38 MAPK Is a Major Regulator of Amyloid Beta-Induced IL-6 Expression in Human Microglia. Mol Neurobiol. 2022 Sep; 59(9):5284-5298.

View in: PubMed
Cook M, Lin H, Mishra SK, Wang GY. BAY 11-7082 inhibits the secretion of interleukin-6 by senescent human microglia. Biochem Biophys Res Commun. 2022 08 20; 617(Pt 1):30-35.

View in: PubMed
Cao X, Tian Y, Nguyen V, Zhang Y, Gao C, Yin R, Carver W, Fan D, Albrecht H, Cui T, Tan W. Spike protein of SARS-CoV-2 activates macrophages and contributes to induction of acute lung inflammation in male mice. FASEB J. 2021 09; 35(9):e21801.

View in: PubMed
Lee JS, Chowdhury N, Roberts JS, Yilmaz Ö. Host surface ectonucleotidase-CD73 and the opportunistic pathogen, Porphyromonas gingivalis, cross-modulation underlies a new homeostatic mechanism for chronic bacterial survival in human epithelial cells. Virulence. 2020 12; 11(1):414-429.

View in: PubMed
Nguyen XX, Nishimoto T, Takihara T, Mlakar L, Bradshaw AD, Feghali-Bostwick C. Lysyl oxidase directly contributes to extracellular matrix production and fibrosis in systemic sclerosis. Am J Physiol Lung Cell Mol Physiol. 2021 01 01; 320(1):L29-L40.

View in: PubMed
Knochelmann HM, Dwyer CJ, Smith AS, Bowers JS, Wyatt MM, Nelson MH, Rangel Rivera GO, Horton JD, Krieg C, Armeson K, Lesinski GB, Rubinstein MP, Li Z, Paulos CM. IL6 Fuels Durable Memory for Th17 Cell-Mediated Responses to Tumors. Cancer Res. 2020 09 15; 80(18):3920-3932.

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Eckard AR, Hughes HY, Hagood NL, O'Riordan MA, Labbato D, Kosco JC, Scott SE, McComsey GA. Fibroblast Growth Factor 21 Is Elevated in HIV and Associated With Interleukin-6. J Acquir Immune Defic Syndr. 2020 04 15; 83(5):e30-e33.

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Babatunde OA, Arp Adams S, Truman S, Sercy E, Murphy AE, Khan S, Hurley TG, Wirth MD, Choi SK, Johnson H, Hebert JR. The impact of a randomized dietary and physical activity intervention on chronic inflammation among obese African-American women. Women Health. 2020 08; 60(7):792-805.

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Renaud L, da Silveira WA, Takamura N, Hardiman G, Feghali-Bostwick C. Prominence of IL6, IGF, TLR, and Bioenergetics Pathway Perturbation in Lung Tissues of Scleroderma Patients With Pulmonary Fibrosis. Front Immunol. 2020; 11:383.

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Geng L, Tang X, Wang S, Sun Y, Wang D, Tsao BP, Feng X, Sun L. Reduced Let-7f in Bone Marrow-Derived Mesenchymal Stem Cells Triggers Treg/Th17 Imbalance in Patients With Systemic Lupus Erythematosus. Front Immunol. 2020; 11:233.

View in: PubMed

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