Codon, Nonsense

"Codon, Nonsense" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An amino acid-specifying codon that has been converted to a stop codon (CODON, TERMINATOR) by mutation. Its occurance is abnormal causing premature termination of protein translation and results in production of truncated and non-functional proteins. A nonsense mutation is one that converts an amino acid-specific codon to a stop codon.

Descriptor ID	D018389
MeSH Number(s)	D13.444.735.544.355.250.235 G05.360.335.355.250.235 G05.365.590.195
Concept/Terms	Codon, Nonsense Codon, Nonsense Premature Termination Codon Codon, Premature Termination Codons, Premature Termination Premature Termination Codons Termination Codon, Premature Termination Codons, Premature Premature Stop Codon Codon, Premature Stop Codons, Premature Stop Premature Stop Codons Stop Codon, Premature Stop Codons, Premature Nonsense Codon Codons, Nonsense Nonsense Codons Codon, Termination, Premature Mutation, Nonsense Mutation, Nonsense Mutations, Nonsense Nonsense Mutations Nonsense Mutation Ochre Nonsense Codon Ochre Nonsense Codon Codon, Ochre Nonsense Codons, Ochre Nonsense Nonsense Codon, Ochre Nonsense Codons, Ochre Ochre Nonsense Codons Ochre Nonsense Mutation Ochre Nonsense Mutation Mutation, Ochre Nonsense Mutations, Ochre Nonsense Nonsense Mutation, Ochre Nonsense Mutations, Ochre Ochre Nonsense Mutations Amber Nonsense Mutation Amber Nonsense Mutation Amber Nonsense Mutations Mutation, Amber Nonsense Mutations, Amber Nonsense Nonsense Mutation, Amber Nonsense Mutations, Amber Opal Nonsense Mutation Opal Nonsense Mutation Mutation, Opal Nonsense Mutations, Opal Nonsense Nonsense Mutation, Opal Nonsense Mutations, Opal Opal Nonsense Mutations Amber Nonsense Codon Amber Nonsense Codon Amber Nonsense Codons Codon, Amber Nonsense Codons, Amber Nonsense Nonsense Codons, Amber Nonsense Codon, Amber Codon, Unassigned Codon, Unassigned Codons, Unassigned Unassigned Codons Unassigned Codon Opal Nonsense Codon Opal Nonsense Codon Codon, Opal Nonsense Codons, Opal Nonsense Nonsense Codon, Opal Nonsense Codons, Opal Opal Nonsense Codons

Below are MeSH descriptors whose meaning is more general than "Codon, Nonsense".

Chemicals and Drugs [D]
Nucleic Acids, Nucleotides, and Nucleosides [D13]
Nucleic Acids [D13.444]
RNA [D13.444.735]
RNA, Messenger [D13.444.735.544]
Codon [D13.444.735.544.355]
Codon, Terminator [D13.444.735.544.355.250]
Codon, Nonsense [D13.444.735.544.355.250.235]
Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Genetic Code [G05.360.335]
Codon [G05.360.335.355]
Codon, Terminator [G05.360.335.355.250]
Codon, Nonsense [G05.360.335.355.250.235]
Genetic Variation [G05.365]
Mutation [G05.365.590]
Codon, Nonsense [G05.365.590.195]

Below are MeSH descriptors whose meaning is more specific than "Codon, Nonsense".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Codon, Nonsense" by people in this website by year, and whether "Codon, Nonsense" was a major or minor topic of these publications.

Bar chart showing 12 publications over 9 distinct years, with a maximum of 3 publications in 2008

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2005	1	0	1
2008	0	3	3
2009	0	2	2
2010	1	0	1
2016	0	1	1
2017	0	1	1
2019	0	1	1
2021	0	1	1

Below are the most recent publications written about "Codon, Nonsense" by people in Profiles.

Perez CJ, Mecklenburg L, Fernandez A, Cantero M, de Souza TA, Lin K, Dent SYR, Montoliu L, Awgulewitsch A, Benavides F. Naked (N) mutant mice carry a nonsense mutation in the homeobox of Hoxc13. Exp Dermatol. 2022 03; 31(3):330-340.

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Butler DC, Glen WB, Schandl C, Phillips A. Glycogen Storage Disease Type IV Diagnosed at Fetal Autopsy. Pediatr Dev Pathol. 2020 Aug; 23(4):301-305.

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Palmer EE, Kumar R, Gordon CT, Shaw M, Hubert L, Carroll R, Rio M, Murray L, Leffler M, Dudding-Byth T, Oufadem M, Lalani SR, Lewis AM, Xia F, Tam A, Webster R, Brammah S, Filippini F, Pollard J, Spies J, Minoche AE, Cowley MJ, Risen S, Powell-Hamilton NN, Tusi JE, Immken L, Nagakura H, Bole-Feysot C, Nitschké P, Garrigue A, de Saint Basile G, Kivuva E, Scott RH, Rendon A, Munnich A, Newman W, Kerr B, Besmond C, Rosenfeld JA, Amiel J, Field M, Gecz J. A Recurrent De Novo Nonsense Variant in ZSWIM6 Results in Severe Intellectual Disability without Frontonasal or Limb Malformations. Am J Hum Genet. 2017 Dec 07; 101(6):995-1005.

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Huenerberg K, Hudspeth M, Bergmann S, Pai S, Singh B, Duong A. Two cases of Vici syndrome associated with Idiopathic Thrombocytopenic Purpura (ITP) with a review of the literature. Am J Med Genet A. 2016 May; 170A(5):1343-6.

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Kim SH, Speirs CK, Solnica-Krezel L, Ess KC. Zebrafish model of tuberous sclerosis complex reveals cell-autonomous and non-cell-autonomous functions of mutant tuberin. Dis Model Mech. 2011 Mar; 4(2):255-67.

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Chan SS, Naviaux RK, Basinger AA, Casas KA, Copeland WC. De novo mutation in POLG leads to haplotype insufficiency and Alpers syndrome. Mitochondrion. 2009 Sep; 9(5):340-5.

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Cronin JC, Wunderlich J, Loftus SK, Prickett TD, Wei X, Ridd K, Vemula S, Burrell AS, Agrawal NS, Lin JC, Banister CE, Buckhaults P, Rosenberg SA, Bastian BC, Pavan WJ, Samuels Y. Frequent mutations in the MITF pathway in melanoma. Pigment Cell Melanoma Res. 2009 Aug; 22(4):435-44.

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Chan SS, Copeland WC. DNA polymerase gamma and mitochondrial disease: understanding the consequence of POLG mutations. Biochim Biophys Acta. 2009 May; 1787(5):312-9.

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Zhu HJ, Patrick KS, Yuan HJ, Wang JS, Donovan JL, DeVane CL, Malcolm R, Johnson JA, Youngblood GL, Sweet DH, Langaee TY, Markowitz JS. Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis. Am J Hum Genet. 2008 Jun; 82(6):1241-8.

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Wasielewski M, Hanifi-Moghaddam P, Hollestelle A, Merajver SD, van den Ouweland A, Klijn JG, Ethier SP, Schutte M. Deleterious CHEK2 1100delC and L303X mutants identified among 38 human breast cancer cell lines. Breast Cancer Res Treat. 2009 Jan; 113(2):285-91.

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