"Suppression, Genetic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Mutation process that restores the wild-type PHENOTYPE in an organism possessing a mutationally altered GENOTYPE. The second "suppressor" mutation may be on a different gene, on the same gene but located at a distance from the site of the primary mutation, or in extrachromosomal genes (EXTRACHROMOSOMAL INHERITANCE).
| Descriptor ID |
D013489
|
| MeSH Number(s) |
G05.365.590.835 G05.558.835
|
| Concept/Terms |
Suppression, Genetic- Suppression, Genetic
- Genetic Suppression
- Genetic Suppressions
- Suppressions, Genetic
Suppressor Mutation- Suppressor Mutation
- Mutation, Suppressor
- Mutations, Suppressor
- Suppressor Mutations
|
Below are MeSH descriptors whose meaning is more general than "Suppression, Genetic".
Below are MeSH descriptors whose meaning is more specific than "Suppression, Genetic".
This graph shows the total number of publications written about "Suppression, Genetic" by people in this website by year, and whether "Suppression, Genetic" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Suppression, Genetic" by people in Profiles.
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Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ? 2 renders tumor cells dependent on its paralogous gene COPZ1. Proc Natl Acad Sci U S A. 2011 Jul 26; 108(30):12449-54.
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Persistent growth failure in Prader-Willi syndrome associated with short-chain acyl-CoA dehydrogenase gene variant. J Child Neurol. 2008 Jan; 23(1):112-7.
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The ERK1/2 pathway modulates nuclear PTEN-mediated cell cycle arrest by cyclin D1 transcriptional regulation. Hum Mol Genet. 2006 Sep 01; 15(17):2553-9.
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Cell death in Escherichia coli dnaE(Ts) mutants incubated at a nonpermissive temperature is prevented by mutation in the cydA gene. J Bacteriol. 2004 Apr; 186(7):2147-55.
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Genetic suppressor elements in the characterization and identification of tumor suppressor genes. Methods Mol Biol. 2003; 222:413-36.
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Altered expression of ubiquitous kinesin heavy chain results in resistance to etoposide and hypersensitivity to colchicine: mapping of the domain associated with drug response. Cancer Res. 1998 Aug 01; 58(15):3423-8.
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Isolation of genetic suppressor elements (GSEs) from random fragment cDNA libraries in retroviral vectors. Methods Mol Biol. 1997; 69:221-40.
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Mevalonate regulates polysome distribution and blocks translation-dependent suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA: relationship to translational control. Somat Cell Mol Genet. 1995 May; 21(3):189-204.
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Isolation of dominant negative mutants and inhibitory antisense RNA sequences by expression selection of random DNA fragments. Nucleic Acids Res. 1992 Feb 25; 20(4):711-7.
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Pretranslational suppression of an insulin-responsive glucose transporter in rats with diabetes mellitus. Science. 1989 Jul 07; 245(4913):60-3.